1.
J Org Chem
; 67(21): 7429-31, 2002 Oct 18.
Artículo
en Inglés
| MEDLINE
| ID: mdl-12375975
RESUMEN
Lewis acid Mg(ClO4)2, combined with NBS, in CH3CN or EtOAc provided mild and fast bromination of 1,3-dicarbonyl compounds. In particular, this protocol could be applied to the alpha-monobromination of alpha-unsubstituted beta-keto esters. Similar Lewis acid catalysis was also extended to the alpha-chlorination and iodination of 1,3-dicarbonyl compounds with NCS and NIS, respectively.