Alterações morfológicas de pele de camundongos inoculados com o veneno total da serpente Philodryas nattereri / Morphological alterations in mice skins inoculated with the total snake venom of Philodryas nattereri / Las alteraciones morfológicas en la piel de ratones causadas por el veneno de la serpiente Philodryas nattereri

Venenos de serpentes são compostos por substâncias ativas complexas, sendo a maioria delas de natureza proteica, causando diversos efeitos no ser humano e animais domésticos podendo levar ao óbito. Philodryas nattereri é uma serpente nativa da região do Ceará, sendo encontrada em todo o estado. Esse estudo teve por objetivo conhecer as alterações morfofisiológicas de pele de camundongos após inoculação com o veneno total desta serpente. Os animais foram distribuídos em dois grupos que receberam concentrações de 40µg/mL e 20 µg/mL respectivamente, inoculados via subcutânea, além de um terceiro grupo que recebeu via intradérmica 40µg/mL do veneno. Os resultados macroscópicos apresentaram a presença de uma crosta na região inoculada, bem como a presença de hemorragia, tal atividade foi confirmada por achado histopatológico. Microscopicamente, todos os grupos experimentais apresentaram infiltrado inflamatório linfoblástico e de polimorfonucleares, hemorragia, edema, e presença de fibrose. O veneno da serpente Philodryas nattereri alterou a arquitetura normal do tegumento. Nossos resultados corroboraram em demonstrar tais alterações, uma vez que esta substância tóxica de origem animal, presente na nossa biodiversidade nordestina apresenta poucos dados na literatura, sendo desta forma, uma importante ferramenta para estudos das alterações morfofisiológicas de pele.

Snake venoms are composed of complex active substances, most of them of protein nature, causing various effects on humans and domestic animals and can lead to death. Philodryas nattereri is a native snake Ceara region, found throughout the state. This study aimed to know the morphological and physiological changes in mouse skin after inoculation with the total venom this serpente. The animals were divided into two groups that received concentrations of 40µg/mL and 20µg/mL respectively, inoculated subcutaneously, and a third group that received intradermal 40µg/mL of the venom. The macroscopic results showed the presence of a crust in the inoculated area, and the presence of bleeding, this activity was confirmed by histopathological analysis. Microscopically, all experimental groups had lymphoblastic and polymorphonuclear inflammatory infiltration, hemorrhage, edema, and fibrosis. The venom of the snake Philodryas nattereri altered the normal integument architecture. Our results corroborate to demonstrate such changes, since this toxic substance of animal origin present in our Northeast biodiversity presents few literature data, thereby being an important tool for the study of morphological and physiological changes in the skin.

Los venenos de serpientes se componen de sustancias activas complejas, la mayoría de ellos de naturaleza proteica, provocando diversos efectos sobre los seres humanos y en los animales domésticos pueden llevar a la muerte. Philodryas nattereri es una serpiente nativa de la región de Ceará, que se encuentra en todo el estado. Este estudio tuvo como objetivo conocer los cambios morfológicos y fisiológicos en la piel de ratones después de la inoculación con todo el veneno de esta serpiente. Los animales fueron divididos en dos grupos que recibieron las concentraciones de 40µg/mL y 20µg /mL, respectivamente, por vía subcutánea inoculado, y un tercer grupo recibieron intradérmica 40µg/mL veneno. Los resultados macroscópicos mostraron la presencia de una costra en el área inoculada, y la presencia de sangrado, esta actividad se confirmó por análisis histopatológica. Microscópicamente, todos los grupos experimentales tuvieron infiltración linfoblástica y polimorfonucleares inflamatoria, hemorragia, edema y fibrosis. El veneno de la serpiente Philodryas nattereri altera la arquitectura normal del tegumento. Nuestros resultados corroboran para demostrar tales cambios, ya que esta sustancia tóxica de origen animal presente en nuestra biodiversidad Northeast presenta pocos datos de la literatura, siendo por lo tanto una herramienta importante para el estudio de los cambios morfológicos y fisiológicos en la piel.

Alterações morfológicas de pele de camundongos inoculados com o veneno total da serpente Philodryas nattereri / Morphological alterations in mice skins inoculated with the total snake venom of Philodryas nattereri / Las alteraciones morfológicas en la piel de ratones causadas por el veneno de la serpiente Philodryas nattereri

Venenos de serpentes são compostos por substâncias ativas complexas, sendo a maioria delas de natureza proteica, causando diversos efeitos no ser humano e animais domésticos podendo levar ao óbito. Philodryas nattereri é uma serpente nativa da região do Ceará, sendo encontrada em todo o estado. Esse estudo teve por objetivo conhecer as alterações morfofisiológicas de pele de camundongos após inoculação com o veneno total desta serpente. Os animais foram distribuídos em dois grupos que receberam concentrações de 40µg/mL e 20 µg/mL respectivamente, inoculados via subcutânea, além de um terceiro grupo que recebeu via intradérmica 40µg/mL do veneno. Os resultados macroscópicos apresentaram a presença de uma crosta na região inoculada, bem como a presença de hemorragia, tal atividade foi confirmada por achado histopatológico. Microscopicamente, todos os grupos experimentais apresentaram infiltrado inflamatório linfoblástico e de polimorfonucleares, hemorragia, edema, e presença de fibrose. O veneno da serpente Philodryas nattereri alterou a arquitetura normal do tegumento. Nossos resultados corroboraram em demonstrar tais alterações, uma vez que esta substância tóxica de origem animal, presente na nossa biodiversidade nordestina apresenta poucos dados na literatura, sendo desta forma, uma importante ferramenta para estudos das alterações morfofisiológicas de pele.(AU)

Snake venoms are composed of complex active substances, most of them of protein nature, causing various effects on humans and domestic animals and can lead to death. Philodryas nattereri is a native snake Ceara region, found throughout the state. This study aimed to know the morphological and physiological changes in mouse skin after inoculation with the total venom this serpente. The animals were divided into two groups that received concentrations of 40µg/mL and 20µg/mL respectively, inoculated subcutaneously, and a third group that received intradermal 40µg/mL of the venom. The macroscopic results showed the presence of a crust in the inoculated area, and the presence of bleeding, this activity was confirmed by histopathological analysis. Microscopically, all experimental groups had lymphoblastic and polymorphonuclear inflammatory infiltration, hemorrhage, edema, and fibrosis. The venom of the snake Philodryas nattereri altered the normal integument architecture. Our results corroborate to demonstrate such changes, since this toxic substance of animal origin present in our Northeast biodiversity presents few literature data, thereby being an important tool for the study of morphological and physiological changes in the skin.(AU)

Los venenos de serpientes se componen de sustancias activas complejas, la mayoría de ellos de naturaleza proteica, provocando diversos efectos sobre los seres humanos y en los animales domésticos pueden llevar a la muerte. Philodryas nattereri es una serpiente nativa de la región de Ceará, que se encuentra en todo el estado. Este estudio tuvo como objetivo conocer los cambios morfológicos y fisiológicos en la piel de ratones después de la inoculación con todo el veneno de esta serpiente. Los animales fueron divididos en dos grupos que recibieron las concentraciones de 40µg/mL y 20µg /mL, respectivamente, por vía subcutánea inoculado, y un tercer grupo recibieron intradérmica 40µg/mL veneno. Los resultados macroscópicos mostraron la presencia de una costra en el área inoculada, y la presencia de sangrado, esta actividad se confirmó por análisis histopatológica. Microscópicamente, todos los grupos experimentales tuvieron infiltración linfoblástica y polimorfonucleares inflamatoria, hemorragia, edema y fibrosis. El veneno de la serpiente Philodryas nattereri altera la arquitectura normal del tegumento. Nuestros resultados corroboran para demostrar tales cambios, ya que esta sustancia tóxica de origen animal presente en nuestra biodiversidad Northeast presenta pocos datos de la literatura, siendo por lo tanto una herramienta importante para el estudio de los cambios morfológicos y fisiológicos en la piel.(AU)

Hipotireoidismo canino - relato de caso / Canine hypothyroidism - case report

Hypothyroidism is an endocrine disease more diagnosed in dogs. The clinical signs most found are lethargy, weight gain, coat coarse and scanty, nonpruritic alopecia and cold intolerance. In this study, we aimed to report a case of canine hypothyroidism in order to clarify important points of this disease, thus contributing to future diagnosis of similar cases. A bitch of 6-year-old was taken to the vet presenting overweight, exercise intolerance, coat coarse, excess of coat loss and hyperpigmentation of skin. Based on exams accomplished as free T4 measurement was diagnosed hypothyroidism and instituted treatment was l-thyroxine indose rate of 11 μg/kg twice daily.

Redução de fratura de côndilo lateral do úmero com parafuso leg e pino de Steinmann – relato de caso / Lateral condyle fracture reduction in the humerus of a dog with compressive screw and Steinmann pin – case report

Cases of fractures are very common in veterinary clinics and hospitals, often with small animals affected. A fracture can be defined as complete or incomplete disruption of the continuity of a bone or cartilage. The humerus form the skeleton arm. It is a long bone which lies obliquely against the ventral part of the thorax. It plays a central role in the movement of the forelimb. The goal of this study is to describe a case report of a lateral condylar fracture reduction in the humerus of a dog using the compressive screw technique and Steinmann pin.

Urolitíase em Schnauzer: uma abordagem clínica e cirúrgica / Urolithiasis in Schnauzer: a clinical and surgical approach

The urolithiasis in dogs is a very common disease in the veterinary clinic. It is characterized by mineralized salt accumulation in some region of the urinary tract and is more common in areas of the bladder and urethra, but rare in the kidneys and ureters. This study aims to report a case of urolithiasis in dog. It was answered in Clinical Veterinary ETAVE, Fortaleza, Ceará, a female, race Schnauzer, 10 years old, whose diet consisted of food and home cooking. There were made physical and complementary examinations of the animal, establishing the diagnosis of urolithiasis. Cystotomy was prescribed to remove the uroliths of the bladder, as well as medicine and the animal dietary modification. The uroliths were characterized as mixed. Surgical treatment associated with therapeutic diets is an excellent option for the control of relapses.

Urolitíase em Schnauzer: uma abordagem clínica e cirúrgica / Urolithiasis in Schnauzer: a clinical and surgical approach

The urolithiasis in dogs is a very common disease in the veterinary clinic. It is characterized by mineralized salt accumulation in some region of the urinary tract and is more common in areas of the bladder and urethra, but rare in the kidneys and ureters. This study aims to report a case of urolithiasis in dog. It was answered in Clinical Veterinary ETAVE, Fortaleza, Ceará, a female, race Schnauzer, 10 years old, whose diet consisted of food and home cooking. There were made physical and complementary examinations of the animal, establishing the diagnosis of urolithiasis. Cystotomy was prescribed to remove the uroliths of the bladder, as well as medicine and the animal dietary modification. The uroliths were characterized as mixed. Surgical treatment associated with therapeutic diets is an excellent option for the control of relapses.(AU)

Hipotireoidismo canino - relato de caso / Canine hypothyroidism - case report

Hypothyroidism is an endocrine disease more diagnosed in dogs. The clinical signs most found are lethargy, weight gain, coat coarse and scanty, nonpruritic alopecia and cold intolerance. In this study, we aimed to report a case of canine hypothyroidism in order to clarify important points of this disease, thus contributing to future diagnosis of similar cases. A bitch of 6-year-old was taken to the vet presenting overweight, exercise intolerance, coat coarse, excess of coat loss and hyperpigmentation of skin. Based on exams accomplished as free T4 measurement was diagnosed hypothyroidism and instituted treatment was l-thyroxine indose rate of 11 μg/kg twice daily.(AU)

Redução de fratura de côndilo lateral do úmero com parafuso leg e pino de Steinmann relato de caso / Lateral condyle fracture reduction in the humerus of a dog with compressive screw and Steinmann pin case report

Cases of fractures are very common in veterinary clinics and hospitals, often with small animals affected. A fracture can be defined as complete or incomplete disruption of the continuity of a bone or cartilage. The humerus form the skeleton arm. It is a long bone which lies obliquely against the ventral part of the thorax. It plays a central role in the movement of the forelimb. The goal of this study is to describe a case report of a lateral condylar fracture reduction in the humerus of a dog using the compressive screw technique and Steinmann pin.(AU)