[Aminotransferase and lactate dehydrogenase activity in the blood of dogs exposed to the joint action of external gamma- and internal alpha-radiation]. / Aktivnost' aminotransferaz i laktatdegidrogenazy v syvorotke krovi sobak pri sovmestnom vozdeistvii vneshnego gamma- i inkorporirovannogo al'fa-izluchenii.

After the effect of external gamma-radiation (6.5 to 51.6 mC/kg) and inhaled 239Pu submicron oxide, containing 25% of 241Am, (approximately 7 to 10 kBq/kg) delivered separately and in a combination, activities of alanine-aspartate aminotransferase and lactate dehydrogenase changed in an undulatory manner tending to increase at later times; the change rating was a function of type and level of radiation as well as the time lapsed from the onset of exposure. The combined effect of gamma- and alpha-radiation did not exceed the additive effect of the two factors delivered separately.

[Lactate dehydrogenase and alkaline phosphatase activity of the serum and radiation-induced osteosarcoma in rats]. / Aktivnost' laktatdegidrogenazy i shchelochnoi fosfatazy v syvorotke krovi i osteosarkomakh, voznikshikh u krys pri radiatsionnom vozdeistvii.

Alkaline phosphatase (AP) and lactate dehydrogenase (LDG) activities are stained in rat blood serum and osteogenic sarcomas of different histostructure, which developed following a combined exposure of 239Pu (92.5 kBq/kg of body mass) and gamma-irradiation (103.2 mC/kg), as well as following separate exposures to these factors at the same doses. Alkaline phosphatase activities in blood serum and neoplastic bone tissues were found to correlate with the histostructure of osteogenic sarcomas, the distribution and the localization of metastases. Shifts in an isoenzymic spectrum of lactate dehydrogenase in neoplastic bone tissues and blood serum are observed, with a tendency to an increase in the LDG3 and LDG4 and to a decrease in the LDG5 fractions.

[Alkaline phosphatase and transaminase activity in the liver and blood serum of rats in the late periods following combined exposure to external gamma radiation and alpha radiation from plutonium-239]. / Aktivnost' shchelochnoi fosfatazy i transaminaz v pecheni i syvorotke krovi krys v otdalennye sroki posle sochetannogo vozdeistviia vneshnego gamma-izlucheniia i al'fa-izlucheniia plutoniia-239.

A study was made of activity of alkaline phosphatase and alanine- and aspartate aminotransferase in rat liver and blood serum at remote times after external gamma-irradiation combined with internal exposure to 239Pu nitrate delivered in two chronically effective doses. The radionuclide was shown to be mainly responsible for the changes observed in activity of the enzymes under study. The degree to which the changes were manifest depended upon dose of plutonium administered.

[Biochemical changes in rat tissues as affected by the combined action of external gamma-radiation and 239Pu in different doses]. / Biokhimicheskie sdvigi v tkaniakh krys pri sochetannom vozdeistvii vneshnego gamma-izlucheniia i 239Pu v raznykh dozakh.

Under the combined effect of external gamma-radiation (25.8 and 103.2 mC/kg) and 239Pu (18.5 and 92.5 kBq/kg body weight) the changes in the nucleic acids of rat thymus tissues depended upon the intensity of gamma- and alpha-radiation. The damage to the thymus produced by the combined effect was weaker than that of the effect of the two types of radiation delivered separately. In bone tissue, summation of the oppositely directed changes in alkaline phosphatase activity was registered after the effect of gamma-radiation and 239Pu delivered separately.

[Change in aminotransferase and alkaline phosphatase activity in rats exposed to plutonium-239 in combination with external gamma-radiation]. / Izmenenie aktivnosti aminotransferaz i shchelochnoi fosfatazy u krys pri sochetannom vozdeistvii plutoniia-239 i vneshnego gamma-oblucheniia.

Activity of alanine- and aspartate aminotransferases and alkaline phosphatase in the liver and blood serum was studied during 17 months after the administration of plutonium-239 (92.5 kBq/kg) to rats preirradiated with gamma-rays (103.2 and 51.6 mC/kg). The dynamics of changes in the activity of the enzymes under study was undulatory; the changes observed in the enzymic activity under the combined effect of the two types of radiation exhibited certain distinctions from those caused by their separate action.