[ADP-Induced Recalcified Blood Clotting Time as a Marker of Rethrombosis Risk and Effectiveness of Antiplatelet Therapy in Acute Coronary Syndrome].

PURPOSE: to assess the possibility of the use of ADP induced blood-clotting time measurement in clinical practice prognostication of the course of acute coronary syndrome (ACS) and assessment of effectiveness of antiplatelet therapy (APT). MATERIALS AND METHODS: We enrolled in the study 163 male patients admitted to the coronary unit for acute coronary syndrome (ACS) and 38 male practically healthy volunteers (PHV). ADP induced blood-clotting time (ADP BCT) was measured as time (sec) between addition of ADP (10 µcmol) to recalcificated sample of citrate blood and clot formation. In healthy volunteers ADP BCT was determined before and 45 minutes after oral administration of acetylsalicylic acid (ASA, 250 mg). Risk of cardiovascular death was calculated using the GRACE score. Platelet function tests were performed by optical aggregometry. Follow-up period for patients with ACS was 24 months. The primary end point (PEP) was the composite of cardiovascular death and rehospitalization. RESULTS: In ACS patients ADP BCT was significantly lower than in PHV: 134.8 (109.9; 161.3) vs 85.7 (60.5; 108.7) sec, p=0.015. In PHV ASA increased ADP BCT - 103.2 (95.1; 130.7) vs 133.1 (102.8; 154.3) sec, p=0.041. ADP BCT correlated with age in both PHV and patients (R= -0.431, p.

[Masked Arterial Hypertension in Employed Adult Women: Aspects of Screening and Prognostication].

Masked (M) hypertension (H) remains an unsolved problem of cardiology. Gender aspects of MH require further pathogenetic deciphering and clinical interpretation. We used breathe-hold test and 24-hour blood pressure (BP) monitoring for detection of MH in 275 female middle- aged employees. MH Prevalence of MH was 7.7%. Special clinical and pathogenetic characteristics of MH in studied sample were as follows: high sensitivity of mean hemodynamic BP; body mass index increase, tendency to elevation of fasting glycaemia and lowering of glomerular filtration rate, more frequent presence of dyslipidemia in comparison with normotensive patients, absence of association with levels of anxiety and depression. Ten year risk of fatal cardiovascular events in women with MH was comparable with that among female patients with overt hypertension (0.76 vs 0.68 %). Received data became a basis for elaboration of screening programs of early detection and prevention of H.

[Plasma dehydratation self-organization in patients with coronary heart].

The functional morphology of biological fluids is a basically new branch of science, which is based on the study of a result of phase change processes in the substrate under study. The paper shows the specific features of plasma spatial organization in patients with chronic and acute coronary heart disease (CHD). The findings may be used as an additional criterion for the differential diagnosis of the above forms of CHD and open up a new line in the diagnosis and risk stratification in CHD patients.

[Social stress as a risk factor for ischemic heart disease].

AIM: To study dynamics of ischemic heart disease in exposure of the population of an industrial city to social-economic stress. MATERIAL AND METHODS: Official annual records of Saratov city Health Administration for 1989-1998. In public health evaluation, cardiovascular morbidity is the index rapidly reacting to social-economic changes. Descrete data of myocardial infarction and angina prevalence for the analysed time were approximated by polynomes of high degree. As a result, the first and second derivatives--speed and acceleration--were obtained. RESULTS: A rise in MI morbidity reflected a rise in social tension. The disturbance of the population system of an industrial center (in conditions of a social stress) is accompanied by marked deformation of the profile of cardiovascular diseases in the industrial region: the growth of MI prevalence is associated with lowering of angina pectoris morbidity. CONCLUSION: A rise in MI incidence rate is proposed as an indicator of social-economic stability or instability. Instability of IHD morbidity in the population allows consideration of social stress as its risk factor.

[Effect of high concentrations of glucose on physiological parameters of platelets in patients with ischemic heart disease.]. / Vliianie gliukozy vysokikh kontsentratsii na fiziologicheskie parametry éritrotsitov bol'nykh ishemicheskoi bolezn'iu serdtsa.

Analysis of functional state of the erythrocyte system was carried out in 45 patients with stable class II and III angina including those with concomitant non insulin dependent diabetes and in 15 practically healthy subjects. The analysis was made in the process of upsetting the balance of the erythrocyte system by incubation with high concentrations of glucose in vitro. Functional state of erythrocytes was assessed by construction of fragments of a phase portrait on a plane representing relationship between dimensions of erythrocytes, glucose concentration and rate of the above mentioned process.