Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Más filtros










Base de datos
Intervalo de año de publicación
1.
Anticancer Res ; 16(6B): 3833-8, 1996.
Artículo en Inglés | MEDLINE | ID: mdl-9042266

RESUMEN

UGP, the beta-core fragment of human chorionic gonadotropin has been proposed as a tumor marker for gynecological malignancies. This fragment may be detected in a single morning-specimen of urine using an enzyme immunoassay. In this study, the diagnostic usefulness of urine UGP and serum CA 125 measurement for gynecological neoplasias (149 cases) was evaluated using a control group of patients with benign gynecological diseases (69 cases) and healthy females (99 cases). Considering the neoplastic patients in comparison to patients with benign diseases, the best diagnostic efficiency (78%) was found to correspond to a cut-off level of 120 pmol/mol creatinine the sensitivity being 73% and the specificity 90%. With this cut-off, an efficiency of 82% for healthy controls was obtained. Since the menopausal condition increases UGP levels, and though no significant difference for UGP was found between healthy subjects and patients with benign diseases, we decided to consider the reference populations as a single group. Thus, we evaluated the UGP performance on the basis of menopausal status. When a specificity of 95% was fixed, the cut-off values were 120 and 180 pmol/mol creatinine for pre- and postmenopausal women respectively, the sensitivity being 73% and 64%. Finally the combined evaluation of UGP and CA 125 improved their individual clinical efficiency for the diagnosis of ovarian serous cystadenocarcinomas, assuring a sensitivity of 86% and a specificity of 89%.


Asunto(s)
Biomarcadores de Tumor/sangre , Biomarcadores de Tumor/orina , Antígeno Ca-125/sangre , Gonadotropina Coriónica Humana de Subunidad beta/orina , Neoplasias de los Genitales Femeninos/sangre , Neoplasias de los Genitales Femeninos/orina , Fragmentos de Péptidos/orina , Adulto , Anciano , Diagnóstico Diferencial , Femenino , Enfermedades de los Genitales Femeninos/sangre , Enfermedades de los Genitales Femeninos/orina , Neoplasias de los Genitales Femeninos/diagnóstico , Humanos , Persona de Mediana Edad
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA
...