[Analysis of antihypertensive effectiveness by means of ambulatory blood pressure monitoring. Usefulness of the Discrete Fourier Transform Model]. / Análisis de la efectividad antihipertensiva mediante el monitoreo ambulatorio de presión arterial. Utilidad del modelo de Transformada de Fourier Discreta.

In order to assess the usefulness of the Discrete Fourier Transform Model (DFT) to evaluate time-course drug effects on hypertensive patients studied with Ambulatory Blood Pressure Monitoring (ABPM) a number of experiments were carried out. A total of 10 mild to moderate hypertensive patients were evaluated under placebo and after 8 weeks of active treatment with Enalapril 20 mg per day using ABPM. Systolic and Diastolic blood pressure (SBP and DBP) were registered every 15 minutes during daytime and every 30 minutes at night. Pressure profiles of each patient were initially smoothed by hourly means. DFT was then applied to these profiles. The minimum number of harmonics necessary to generate a statistically significant fitting of the blood pressure profile, were obtained by residuals analysis (run test and analysis of variance of the mean sum of residual squares with each new harmonic incorporated to the model). A profile of the blood pressure differences (treatment-placebo) with the rough data of each patient was smoothed by hourly means. DFT was applied again on these substraction profiles. To estimate peak and trough drug effects for the blood pressure decrease function, maximum, minimum and inflexion points were calculated defining the following parameters: T peak: time from drug administration to maximum pressure decrease; T late response: time from drug administration to the inflexion point following the last minimum previous to the next dose; BP peak: the maximum blood pressure decrease amplitude; and the slope BP peak/T peak. The stability of the individual circadian rhythm was confirmed for both ABPM controls comparing times of maximum and minimum on the DFT smoothed profiles.(ABSTRACT TRUNCATED AT 250 WORDS)

Analisis de la efectividad antihipertensiva mediante el monitoreo ambulatorio de presion arterial. Utilidad del modelo de Transformada de Fourier Discreta / Analysis of antihypertensive effectiveness by means of ambulatory blood pressure monitoring. Usefulness of the discrete fourier transform model

Se estudiaron 10 pacientes con hipertensión arterial a moderada a quienes se efectuó un monitoreo ambulatorio (MAPA) luego de 30 dias de placebo, y otro al cabo de ocho semanas de tratamiento con una dosis fija de 20 mg de maleato de enalapril. La presión arterial sistólica (PAS) y diastólica (PAD) se registró cada 15 minutos de 07 a 22 hs, y cada 30 minutos de 22 a 07 hs. Los perfiles presores y los perfiles de las diferencias presoras droga-placebo individuales, fueron alisados por los promedios horarios. Luego se aplicó la Transformada de Fourier Discreta (TFD). Se determinó el menor número de armónicas que generan un ajuste estadisticamente significativo por análisis de residuos. En las curvas de diferencias presoras alisadas por TFD, se calcularon máximos, mínimos y puntos de inflexión para determinar: el tiempo de respuesta rápida (intervalo entre toma de la droga y máximo efecto), el tiempo de duración del efecto de la droga (intervalo entre toma de medicación y punto de inflexión, siguiente al último mínimo previo a una nueva dosis) y la pendidente de descenso rápido (cociente entre máximo descenso presor y tiempo de respusta rápida). Dependiendo del paciente, 3 a 5 armónicas en las curvas alisadas por TFD de PAS, PAD y de las diferencias droga-placebo, son suficientes para ajustar los promedios presores horarios. Se confirmó la estabilidad del ritmo circadiano en ambos monitoreos. El efectos se presentó a las 3 hrs (rango: 2 a 5) de toma de dosis; y la duración máxima media del efecto de la medicación fue de 17,6 hs para la PAS y de 18,5 hs para la PAD. Se concluye que las diferencias presoras tratamiento-placebo obtenidas a partir del MAPA y analizadas según el modelo de RFD permiten evaluar los intervalos de tiempo de protección presora asociados a un tratamiento antihipertensivo (AU)

Analisis de la efectividad antihipertensiva mediante el monitoreo ambulatorio de presion arterial. Utilidad del modelo de Transformada de Fourier Discreta / Analysis of antihypertensive effectiveness by means of ambulatory blood pressure monitoring. Usefulness of the discrete fourier transform model

Se estudiaron 10 pacientes con hipertensión arterial a moderada a quienes se efectuó un monitoreo ambulatorio (MAPA) luego de 30 dias de placebo, y otro al cabo de ocho semanas de tratamiento con una dosis fija de 20 mg de maleato de enalapril. La presión arterial sistólica (PAS) y diastólica (PAD) se registró cada 15 minutos de 07 a 22 hs, y cada 30 minutos de 22 a 07 hs. Los perfiles presores y los perfiles de las diferencias presoras droga-placebo individuales, fueron alisados por los promedios horarios. Luego se aplicó la Transformada de Fourier Discreta (TFD). Se determinó el menor número de armónicas que generan un ajuste estadisticamente significativo por análisis de residuos. En las curvas de diferencias presoras alisadas por TFD, se calcularon máximos, mínimos y puntos de inflexión para determinar: el tiempo de respuesta rápida (intervalo entre toma de la droga y máximo efecto), el tiempo de duración del efecto de la droga (intervalo entre toma de medicación y punto de inflexión, siguiente al último mínimo previo a una nueva dosis) y la pendidente de descenso rápido (cociente entre máximo descenso presor y tiempo de respusta rápida). Dependiendo del paciente, 3 a 5 armónicas en las curvas alisadas por TFD de PAS, PAD y de las diferencias droga-placebo, son suficientes para ajustar los promedios presores horarios. Se confirmó la estabilidad del ritmo circadiano en ambos monitoreos. El efectos se presentó a las 3 hrs (rango: 2 a 5) de toma de dosis; y la duración máxima media del efecto de la medicación fue de 17,6 hs para la PAS y de 18,5 hs para la PAD. Se concluye que las diferencias presoras tratamiento-placebo obtenidas a partir del MAPA y analizadas según el modelo de RFD permiten evaluar los intervalos de tiempo de protección presora asociados a un tratamiento antihipertensivo

Análisis de la efectividad antihipertensiva mediante el monitoreo ambulatorio de presión arterial. Utilidad del modelo de Transformada de Fourier Discreta. / [Analysis of antihypertensive effectiveness by means of ambulatory blood pressure monitoring. Usefulness of the Discrete Fourier Transform Model]

In order to assess the usefulness of the Discrete Fourier Transform Model (DFT) to evaluate time-course drug effects on hypertensive patients studied with Ambulatory Blood Pressure Monitoring (ABPM) a number of experiments were carried out. A total of 10 mild to moderate hypertensive patients were evaluated under placebo and after 8 weeks of active treatment with Enalapril 20 mg per day using ABPM. Systolic and Diastolic blood pressure (SBP and DBP) were registered every 15 minutes during daytime and every 30 minutes at night. Pressure profiles of each patient were initially smoothed by hourly means. DFT was then applied to these profiles. The minimum number of harmonics necessary to generate a statistically significant fitting of the blood pressure profile, were obtained by residuals analysis (run test and analysis of variance of the mean sum of residual squares with each new harmonic incorporated to the model). A profile of the blood pressure differences (treatment-placebo) with the rough data of each patient was smoothed by hourly means. DFT was applied again on these substraction profiles. To estimate peak and trough drug effects for the blood pressure decrease function, maximum, minimum and inflexion points were calculated defining the following parameters: T peak: time from drug administration to maximum pressure decrease; T late response: time from drug administration to the inflexion point following the last minimum previous to the next dose; BP peak: the maximum blood pressure decrease amplitude; and the slope BP peak/T peak. The stability of the individual circadian rhythm was confirmed for both ABPM controls comparing times of maximum and minimum on the DFT smoothed profiles.(ABSTRACT TRUNCATED AT 250 WORDS)

Ambulatory blood pressure monitoring and diastolic left ventricular abnormalities in established and borderline hypertension

In order to evaluate left ventricular diastolic function by means of Doppler echocardiography in borderline and established hypertension, identified by office and ABPM, compared with normotensives, 54 subjects: 15 normotensives, 11 borderlines and 28 nontreated mild to moderate essential hypertensives were studied. Age and weight were similar among groups. Established hypertensives showed higher left ventricular mass index (p < 0.05), peak velocity of late left ventricular filling (peak A; p < 0.01), ratio peak A/peak velocity of early ventricular filling, peak E (p < 0.01), velocity time integral of systolic atrial volume (p < 0.001), deceleration half time of peak early diastolic inflow velocity (p < 0.05), left ventricular isovolumic relaxation period (IRP; p < 0.01) than normotensives and lower Doppler indexes of early diastolic left ventricular filling (p < 0.01), peak filling rat normalized to mitral stroke volume (PFRn; p < 0.01) than normotensives. Although borderline hypertensives showed intermediate LVM and Doppler indexes between hypertensives and normotensives only IRP (p < 0.05) and PFRn (p < 0.05) were significant different to normotensives. In conclusion, established hypertension leads to abnormalities in left ventricular diastolic function which can be detected by Doppler echocardiography. In borderline hypertension, the left ventricular diastolic abnormalities are predominantly related to the active process of early diastole. Therefore, these indexes may be early markers of left ventricular dysfunction in hypertension.(Au)

Ambulatory blood pressure monitoring and diastolic left ventricular abnormalities in established and borderline hypertension

In order to evaluate left ventricular diastolic function by means of Doppler echocardiography in borderline and established hypertension, identified by office and ABPM, compared with normotensives, 54 subjects: 15 normotensives, 11 borderlines and 28 nontreated mild to moderate essential hypertensives were studied. Age and weight were similar among groups. Established hypertensives showed higher left ventricular mass index (p < 0.05), peak velocity of late left ventricular filling (peak A; p < 0.01), ratio peak A/peak velocity of early ventricular filling, peak E (p < 0.01), velocity time integral of systolic atrial volume (p < 0.001), deceleration half time of peak early diastolic inflow velocity (p < 0.05), left ventricular isovolumic relaxation period (IRP; p < 0.01) than normotensives and lower Doppler indexes of early diastolic left ventricular filling (p < 0.01), peak filling rat normalized to mitral stroke volume (PFRn; p < 0.01) than normotensives. Although borderline hypertensives showed intermediate LVM and Doppler indexes between hypertensives and normotensives only IRP (p < 0.05) and PFRn (p < 0.05) were significant different to normotensives. In conclusion, established hypertension leads to abnormalities in left ventricular diastolic function which can be detected by Doppler echocardiography. In borderline hypertension, the left ventricular diastolic abnormalities are predominantly related to the active process of early diastole. Therefore, these indexes may be early markers of left ventricular dysfunction in hypertension.

Ambulatory blood pressure monitoring and diastolic left ventricular abnormalities in established and borderline hypertension.

In order to evaluate left ventricular diastolic function by means of Doppler echocardiography in borderline and established hypertension, identified by office and ABPM, compared with normotensives, 54 subjects: 15 normotensives, 11 borderlines and 28 nontreated mild to moderate essential hypertensives were studied. Age and weight were similar among groups. Established hypertensives showed higher left ventricular mass index (p < 0.05), peak velocity of late left ventricular filling (peak A; p < 0.01), ratio peak A/peak velocity of early ventricular filling, peak E (p < 0.01), velocity time integral of systolic atrial volume (p < 0.001), deceleration half time of peak early diastolic inflow velocity (p < 0.05), left ventricular isovolumic relaxation period (IRP; p < 0.01) than normotensives and lower Doppler indexes of early diastolic left ventricular filling (p < 0.01), peak filling rat normalized to mitral stroke volume (PFRn; p < 0.01) than normotensives. Although borderline hypertensives showed intermediate LVM and Doppler indexes between hypertensives and normotensives only IRP (p < 0.05) and PFRn (p < 0.05) were significant different to normotensives. In conclusion, established hypertension leads to abnormalities in left ventricular diastolic function which can be detected by Doppler echocardiography. In borderline hypertension, the left ventricular diastolic abnormalities are predominantly related to the active process of early diastole. Therefore, these indexes may be early markers of left ventricular dysfunction in hypertension.

Ambulatory blood pressure monitoring and diastolic left ventricular abnormalities in established and borderline hypertension.

In order to evaluate left ventricular diastolic function by means of Doppler echocardiography in borderline and established hypertension, identified by office and ABPM, compared with normotensives, 54 subjects: 15 normotensives, 11 borderlines and 28 nontreated mild to moderate essential hypertensives were studied. Age and weight were similar among groups. Established hypertensives showed higher left ventricular mass index (p < 0.05), peak velocity of late left ventricular filling (peak A; p < 0.01), ratio peak A/peak velocity of early ventricular filling, peak E (p < 0.01), velocity time integral of systolic atrial volume (p < 0.001), deceleration half time of peak early diastolic inflow velocity (p < 0.05), left ventricular isovolumic relaxation period (IRP; p < 0.01) than normotensives and lower Doppler indexes of early diastolic left ventricular filling (p < 0.01), peak filling rat normalized to mitral stroke volume (PFRn; p < 0.01) than normotensives. Although borderline hypertensives showed intermediate LVM and Doppler indexes between hypertensives and normotensives only IRP (p < 0.05) and PFRn (p < 0.05) were significant different to normotensives. In conclusion, established hypertension leads to abnormalities in left ventricular diastolic function which can be detected by Doppler echocardiography. In borderline hypertension, the left ventricular diastolic abnormalities are predominantly related to the active process of early diastole. Therefore, these indexes may be early markers of left ventricular dysfunction in hypertension.

Early abnormalities of left ventricular function in essential hypertension induced by exercise

In order to assess their ventricular function at rest and during exercise, 42 essential hypertensives (164 +/- 2/98.7 +/- 2 mmHg) and 12 normotensives (131.7 +/- 4/81.2 +/- 1 mmHg) were studied. Ejection fraction (EF), peak filling rate (PFR) and peak ejection rate (PER) were measured by means of gated radionuclide ventriculography. At rest, no differences in EF, PFR and PER between hypertensives and normotensives were found. During exercise, hypertensives showed lower PFR (5.3 +/- 0.2 EDV/s) and EF (67.7 +/- 1%) than normotensives (PFR 7 +/- 0.5 EDV/s, p < 0.005 and EF 79.4 +/- 2%, p < 0.001). Likewise, hypertensive showed a lower increase from rest to exercise in PFR and in EF than normotensives p < 0.001. In addition, hypertensives showed a great individual variability in EF response to exercise, where 23 patients increased EF more than 5% and 19 patients failed to increase it during stress. Moreover, the last group of patients had higher systolic blood pressure (SBP) both at rest and during exercise than patients who increased EF, p < 0.01. In addition, there was a significantly negative correlation between resting SBP and the variation of Ef (r = 0.47 y: 163.1-0.79X, p < 0.01). Left ventricular mass (LVM) was similar in the two groups of hypertensives. On the other hand, there were no differences in any of the variables analyzed between the hypertensives with LV hypertrophy and those with normal LVM. These findings suggest that abnormalities in both systolic and diastolic LV during exercise may be found in hypertensive patients even before myocardial hypertrophy can be detected (Au)

Early abnormalities of left ventricular function in essential hypertension induced by exercise

In order to assess their ventricular function at rest and during exercise, 42 essential hypertensives (164 +/- 2/98.7 +/- 2 mmHg) and 12 normotensives (131.7 +/- 4/81.2 +/- 1 mmHg) were studied. Ejection fraction (EF), peak filling rate (PFR) and peak ejection rate (PER) were measured by means of gated radionuclide ventriculography. At rest, no differences in EF, PFR and PER between hypertensives and normotensives were found. During exercise, hypertensives showed lower PFR (5.3 +/- 0.2 EDV/s) and EF (67.7 +/- 1%) than normotensives (PFR 7 +/- 0.5 EDV/s, p < 0.005 and EF 79.4 +/- 2%, p < 0.001). Likewise, hypertensive showed a lower increase from rest to exercise in PFR and in EF than normotensives p < 0.001. In addition, hypertensives showed a great individual variability in EF response to exercise, where 23 patients increased EF more than 5% and 19 patients failed to increase it during stress. Moreover, the last group of patients had higher systolic blood pressure (SBP) both at rest and during exercise than patients who increased EF, p < 0.01. In addition, there was a significantly negative correlation between resting SBP and the variation of Ef (r = 0.47 y: 163.1-0.79X, p < 0.01). Left ventricular mass (LVM) was similar in the two groups of hypertensives. On the other hand, there were no differences in any of the variables analyzed between the hypertensives with LV hypertrophy and those with normal LVM. These findings suggest that abnormalities in both systolic and diastolic LV during exercise may be found in hypertensive patients even before myocardial hypertrophy can be detected

Early abnormalities of left ventricular function in essential hypertension induced by exercise.

In order to assess their ventricular function at rest and during exercise, 42 essential hypertensives (164 +/- 2/98.7 +/- 2 mmHg) and 12 normotensives (131.7 +/- 4/81.2 +/- 1 mmHg) were studied. Ejection fraction (EF), peak filling rate (PFR) and peak ejection rate (PER) were measured by means of gated radionuclide ventriculography. At rest, no differences in EF, PFR and PER between hypertensives and normotensives were found. During exercise, hypertensives showed lower PFR (5.3 +/- 0.2 EDV/s) and EF (67.7 +/- 1%) than normotensives (PFR 7 +/- 0.5 EDV/s, p < 0.005 and EF 79.4 +/- 2%, p < 0.001). Likewise, hypertensive showed a lower increase from rest to exercise in PFR and in EF than normotensives p < 0.001. In addition, hypertensives showed a great individual variability in EF response to exercise, where 23 patients increased EF more than 5% and 19 patients failed to increase it during stress. Moreover, the last group of patients had higher systolic blood pressure (SBP) both at rest and during exercise than patients who increased EF, p < 0.01. In addition, there was a significantly negative correlation between resting SBP and the variation of Ef (r = 0.47 y: 163.1-0.79X, p < 0.01). Left ventricular mass (LVM) was similar in the two groups of hypertensives. On the other hand, there were no differences in any of the variables analyzed between the hypertensives with LV hypertrophy and those with normal LVM. These findings suggest that abnormalities in both systolic and diastolic LV during exercise may be found in hypertensive patients even before myocardial hypertrophy can be detected.

Early abnormalities of left ventricular function in essential hypertension induced by exercise.

In order to assess their ventricular function at rest and during exercise, 42 essential hypertensives (164 +/- 2/98.7 +/- 2 mmHg) and 12 normotensives (131.7 +/- 4/81.2 +/- 1 mmHg) were studied. Ejection fraction (EF), peak filling rate (PFR) and peak ejection rate (PER) were measured by means of gated radionuclide ventriculography. At rest, no differences in EF, PFR and PER between hypertensives and normotensives were found. During exercise, hypertensives showed lower PFR (5.3 +/- 0.2 EDV/s) and EF (67.7 +/- 1

) than normotensives (PFR 7 +/- 0.5 EDV/s, p < 0.005 and EF 79.4 +/- 2

, p < 0.001). Likewise, hypertensive showed a lower increase from rest to exercise in PFR and in EF than normotensives p < 0.001. In addition, hypertensives showed a great individual variability in EF response to exercise, where 23 patients increased EF more than 5

and 19 patients failed to increase it during stress. Moreover, the last group of patients had higher systolic blood pressure (SBP) both at rest and during exercise than patients who increased EF, p < 0.01. In addition, there was a significantly negative correlation between resting SBP and the variation of Ef (r = 0.47 y: 163.1-0.79X, p < 0.01). Left ventricular mass (LVM) was similar in the two groups of hypertensives. On the other hand, there were no differences in any of the variables analyzed between the hypertensives with LV hypertrophy and those with normal LVM. These findings suggest that abnormalities in both systolic and diastolic LV during exercise may be found in hypertensive patients even before myocardial hypertrophy can be detected.

Early abnormalities of left ventricular function in essential hypertension induced by exercise.

In order to assess their ventricular function at rest and during exercise, 42 essential hypertensives (164 +/- 2/98.7 +/- 2 mmHg) and 12 normotensives (131.7 +/- 4/81.2 +/- 1 mmHg) were studied. Ejection fraction (EF), peak filling rate (PFR) and peak ejection rate (PER) were measured by means of gated radionuclide ventriculography. At rest, no differences in EF, PFR and PER between hypertensives and normotensives were found. During exercise, hypertensives showed lower PFR (5.3 +/- 0.2 EDV/s) and EF (67.7 +/- 1

) than normotensives (PFR 7 +/- 0.5 EDV/s, p < 0.005 and EF 79.4 +/- 2

, p < 0.001). Likewise, hypertensive showed a lower increase from rest to exercise in PFR and in EF than normotensives p < 0.001. In addition, hypertensives showed a great individual variability in EF response to exercise, where 23 patients increased EF more than 5

and 19 patients failed to increase it during stress. Moreover, the last group of patients had higher systolic blood pressure (SBP) both at rest and during exercise than patients who increased EF, p < 0.01. In addition, there was a significantly negative correlation between resting SBP and the variation of Ef (r = 0.47 y: 163.1-0.79X, p < 0.01). Left ventricular mass (LVM) was similar in the two groups of hypertensives. On the other hand, there were no differences in any of the variables analyzed between the hypertensives with LV hypertrophy and those with normal LVM. These findings suggest that abnormalities in both systolic and diastolic LV during exercise may be found in hypertensive patients even before myocardial hypertrophy can be detected.

Recovery of erythrocyte Na(+)-K(+)-Cl- cotransport activity by enalapril.

We studied total exchangeable sodium, ion transport activity at maximal rate, and erythrocyte Na+ content in response to angiotensin converting enzyme inhibition in mild-to-moderate essential hypertensive patients with normal renal function. Twenty-five patients (mean age 56 years, range 40-62 years) who had abnormal red blood cell Na(+)-K(+)-Cl- cotransport or red blood cell Li(+)-Na+ countertransport were treated with either enalapril (20 mg daily) or hydrochlorothiazide (50 mg daily) during a 30-day period. During the period of enalapril treatment, Na(+)-K+ pump and Na(+)-K(+)-Cl- cotransport increased significantly from 4,282 +/- 255 to 5,236 +/- 325 mumol/l red blood cell/hr (p less than 0.01) and 166 +/- 21 to 220 +/- 24 mumol/l red blood cell/hr (p less than 0.05), respectively. Mean intracellular Na+ content in erythrocytes decreased from 11.4 +/- 0.40 to 10.0 +/- 0.33 mmol/l (p less than 0.01) and exchangeable Na+ from 39.8 +/- 0.6 mmol/kg to 35.6 +/- 0.6 mmol/kg (p less than 0.001). Sodium reduction correlated with the recovery of Na(+)-K(+)-Cl- cotransport activity (r = -0.65, p less than 0.01). During treatment, systolic and diastolic blood pressures were reduced significantly (p less than 0.01). In 12 patients treated with hydrochlorothiazide, Na(+)-K(+)-Cl- cotransport, Na(+)-K+ pump, Na(+)-Li+ countertransport, and Na+ permeability did not change significantly while Na+ content decreased from 11.7 +/- 0.3 to 10.3 +/- 0.2 mmol/l (p less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)

Effects of ACE inhibition on renal haemodynamics in essential hypertension and hypertension associated with chronic renal failure.

Angiotensin II has many actions in the kidney, including regulation and distribution of renal circulation and glomerular filtration, as well as effects on mesangial contraction and on the filtration coefficient. The reduction in circulating and intrarenal angiotensin II by angiotensin converting enzyme (ACE) inhibitors in essential hypertension is associated with a significant increase in renal blood flow and a decrease in filtration fraction, without changes in glomerular filtration rate. In addition, administration of ACE inhibitors can reduce proximal sodium reabsorption via changes in peritubular hydrostatic and oncotic forces resulting from the fall in postglomerular capillary resistance. In severe hypertension the state of the renal vasculature does not allow ACE inhibition to induce similar haemodynamic changes and, therefore, it cannot contribute to renal sodium handling that requires the recruitment of alternate mechanisms. In spite of this, ACE inhibitors may exert a protective effect on the renal function of patients with severe hypertension as well as in those with renal impairment, by lowering systemic and, probably, intraglomerular pressure, reducing proteinuria and slowing the progression of renal failure.

Analysis of left ventricular function by radionuclide ventriculogram in hypertensive patients treated with atenolol

The myocardial effects of a daily oral dose of atenolol were studied by radionuclide multitriggered ventriculogram in 10 patients (7 men and 3 women) with mild to moderate essential hypertension, aged 29 to 53 years (mean 43) at rest and during exercise. Before and after two months of treatment with 100 mg/day orally of atenolol, the following variables were recordedÑ systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), ejection fraction (EF), peak filling rate (PFR) and peak ejection rate (PER). Beta-blockade treatment caused a significant drop in SBP and DBP, both at rest and during exerciseñ HR slowed down at rest and during exercise. PFR diminished at rest and during exercise. PER was reduced at rest and during exercise (p < 0.001). No significant changes in EF were observed after treatment with atenolol. In conclusion,k atenolol impaired left ventricular relaxation in spite of the drop in blood pressure

Analysis of left ventricular function by radionuclide ventriculogram in hypertensive patients treated with atenolol

The myocardial effects of a daily oral dose of atenolol were studied by radionuclide multitriggered ventriculogram in 10 patients (7 men and 3 women) with mild to moderate essential hypertension, aged 29 to 53 years (mean 43) at rest and during exercise. Before and after two months of treatment with 100 mg/day orally of atenolol, the following variables were recordedÑ systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), ejection fraction (EF), peak filling rate (PFR) and peak ejection rate (PER). Beta-blockade treatment caused a significant drop in SBP and DBP, both at rest and during exerciseñ HR slowed down at rest and during exercise. PFR diminished at rest and during exercise. PER was reduced at rest and during exercise (p < 0.001). No significant changes in EF were observed after treatment with atenolol. In conclusion,k atenolol impaired left ventricular relaxation in spite of the drop in blood pressure (AU)

Analysis of left ventricular function by radionuclide ventriculogram in hypertensive patients treated with atenolol.

The myocardial effects of a daily oral dose of atenolol were studied by radionuclide multi-triggered ventriculogram in 10 patients (7 men and 3 women) with mild to moderate essential hypertension, aged 29 to 53 years (mean 43) at rest and during exercise. Before and after two months of treatment with 100 mg/day orally of atenolol, the following variables were recorded: systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), ejection fraction (EF), peak filling rate (PFR) and peak ejection rate (PER). Beta-blockade treatment caused a significant drop in SBP and DBP, both at rest and during exercise; HR slowed down at rest and during exercise. PFR diminished at rest and during exercise. PER was reduced at rest and during exercise (p less than 0.001). No significant changes in EF were observed after treatment with atenolol. In conclusion, atenolol impaired left ventricular relaxation in spite of the drop in blood pressure.

Analysis of left ventricular function by radionuclide ventriculogram in hypertensive patients treated with atenolol.

The myocardial effects of a daily oral dose of atenolol were studied by radionuclide multi-triggered ventriculogram in 10 patients (7 men and 3 women) with mild to moderate essential hypertension, aged 29 to 53 years (mean 43) at rest and during exercise. Before and after two months of treatment with 100 mg/day orally of atenolol, the following variables were recorded: systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), ejection fraction (EF), peak filling rate (PFR) and peak ejection rate (PER). Beta-blockade treatment caused a significant drop in SBP and DBP, both at rest and during exercise; HR slowed down at rest and during exercise. PFR diminished at rest and during exercise. PER was reduced at rest and during exercise (p less than 0.001). No significant changes in EF were observed after treatment with atenolol. In conclusion, atenolol impaired left ventricular relaxation in spite of the drop in blood pressure.