RESUMEN
INTRODUCTION: The main reason for high mortality in breast cancer is local recurrence and metastasis, despite surgery as the first therapeutic option. The anesthesia used in the operation room can determine the immune response. METHODS: A prospective, comparative and non- randomised study in patients undergoing breast cancer surgery was conducted in our hospital after obtaining approval from the Hospital's Institutional Review Board. Patients were divided in two groups: Group A received general anesthesia with propofol and opioids. Group B, in addition to general anesthesia, three interfascial blocks (Pec I, Pec II and BRILMA) were performed in all patients. Three blood samples were taken 1) previous anesthetic induction; 2) two hours after the end of the surgery and 3) 24-48 h after surgery. Leukocytes, CD3, CD4, CD8 and Natural Killer cells were determined at each time. RESULTS: 103 patients were included. 59 (group A) received general anesthesia and 54 (group B) general anesthesia and interfascial blocks. Regarding baseline characteristics, age was significantly higher in the group that received general anesthesia and mastectomy was more frequent in the group that received interfascial blocks. We observed after surgery an increase in leukocytes level that returns close to baseline levels. On the other hand, a reduction in the immune response was observed that also returns to the previous level 48 h after surgery. Group A and B get similar results and also subgroups of hormonal receptors (HER+, PR and/or ER+). CONCLUSIONS: Interfascial blocks in chest wall added to general anesthesia in breast cancer surgery has not shown a significant difference in the inflammatory response or immunological depression compared to general anesthesia as the only anesthetic technique. It seems to trend less immunological depression in the interfascial block group.
Asunto(s)
Anestésicos , Neoplasias de la Mama , Bloqueo Nervioso , Neoplasias de la Mama/patología , Neoplasias de la Mama/cirugía , Femenino , Humanos , Inmunidad , Mastectomía/métodos , Bloqueo Nervioso/métodos , Dolor Postoperatorio , Estudios ProspectivosRESUMEN
La actinomicosis es una enfermedad crónica granulomatosa infrecuente causada por Actinomyces spp, una bacteria anaerobia gram positiva que normalmente coloniza la boca, genitales y tracto digestivo en humanos1. En la mayor parte de los casos, la enfermedad se manifiesta en la región cervicofacial. Sin embargo, se han descrito varios casos en los que la actinomicosis puede simular procesos malignos en localizaciones no comunes, como en el pulmón. Se presenta el caso de una paciente con un cuadro constitucional de 20 días de evolución con una masa paramediastínica, a la que se le diagnostica de actinomicosis pulmonar tras una lobectomía por sospecha clínica de malignidad
Actinomycosis is a rare chronic granulomatous disease caused by Actinomyces spp, an anaerobic gram positive bacteria that colonizes mouth, large bowel and genitals. Actinomycosis occurs most frequently at oral and cervicofacial region. Less commonly affected areas include thoracic, abdominal, pelvic and central nervous system. We report a case about a patient with constitucional syndrome and a paramediastinal ma ss who was diagnosed with pulmonary actinomycosis after a lobectomy because of clinical suspicion of malingnancy
