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INTRODUCTION: Artificial intelligence remote monitoring of clear aligner therapy has recently gained popularity. It uses deep learning algorithms on a patient's mobile smartphone to determine readiness to progress to the next aligner (ie, GO vs NO-GO) and identify areas in which the teeth are not tracking with the clear aligners. This study aimed to assess the repeatability of the Go or No-Go instructions provided by the application and to determine the 3-dimensional discrepancies that constitute an unseat. METHODS: Thirty patients in treatment with clear aligners at an academic clinic were scanned twice using a remote monitoring application on a smartphone, and the results were compared. Gauge repeatability and reproducibility analysis were performed. Intraoral and remote monitoring scans were obtained on the same day from 24 additional clear aligner patients that completed treatment using their final aligners. The intraoral scan after using the final aligner and the stereolithography file of the planned position at the final aligner was compared with measure the maximum discrepancies between the actual and planned position of the teeth. RESULTS: Gauge compatibility of 44.7% was noted. In total 83.3% of patient instructions agreed between Scan 1 and 2, but 0% agreed completely on which and/or how many teeth had tracking issues. Patients who received GO instruction had mean greatest discrepancies of 1.997 mm, 1.901 mm, 0.530 mm, 8.911°, 7.827°, and 7.049° in mesiodistal, buccolingual, occlusogingival, tip, torque, and rotational dimensions, respectively. These discrepancies were not significantly different from patients receiving NO-GO instruction (1.771 mm, 1.808 mm, 0.606 mm, 8.673°, 8.134°, and 6.719° for the corresponding categories). CONCLUSIONS: Despite the study's limitations, these findings suggest concerns with the consistency of remote monitoring instructions because of gauge compatibility over the industry standard. Similarly, large discrepancies in tooth position for patients receiving GO and NO-GO instruction suggest that artificial intelligence decisions were inconsistent with quantitative findings.
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Inteligencia Artificial , Aparatos Ortodóncicos Removibles , Humanos , Estudios Prospectivos , Reproducibilidad de los Resultados , Estereolitografía , Técnicas de Movimiento DentalRESUMEN
OBJECTIVES: To analyze the effect of changes in exposure settings, field of view (FOV), and shielding on radiation to an adult and child phantom from cone-beam computed tomography (CBCT) imaging compared to panoramic and lateral cephalometric radiographs. MATERIALS AND METHODS: The effective dose to an adult and child anthropomorphic phantom by the CS 9300 using various scan protocols was recorded. Absorbed radiation was measured with optically stimulated luminescence dosimeters and effective dose calculated using 2007 International Commission on Radiological Protection tissue weighting factors. Scan protocols included different FOVs, voxel sizes, and standard versus low-dose protocols. Radiation shielding was used when it did not interfere with FOV. Panoramic and lateral cephalometric radiographs were taken with the Orthophos SL. RESULTS: Even with shielding, smaller FOVs, and increased voxel sizes, the effective dose of standard CBCT scans was higher than panoramic and lateral cephalometric radiographs. A shielded limited FOV standard scan combined with a lateral cephalometric radiograph resulted in a lower dose (P < .001) than a full FOV standard scan. Low-dose shielded scans resulted in significant dose reductions to the adult (P < .05) and child (P < .001) phantoms compared to the respective panoramic and lateral cephalometric radiographs combined. Image quality analysis was not possible with radiation equivalent phantoms. CONCLUSIONS: Unlike standard CBCTs, shielded low-dose CBCT protocols in the CS 9300 have lower effective doses than conventional radiographs for adult and child phantoms. If high resolution and cranial base visualization are necessary, combining a shielded LFOV standard exposure with a cephalometric radiograph is recommended.
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Tomografía Computarizada de Haz Cónico , Dosimetría Termoluminiscente , Adulto , Cefalometría , Niño , Humanos , Fantasmas de Imagen , Dosis de RadiaciónRESUMEN
OBJECTIVES: The aim of this study was to determine the effect of shielding and scanning parameters on radiation dose reduction to the organs in the head and neck region in cone beam computed tomography (CBCT). STUDY DESIGN: An anthropomorphic phantom and optically stimulated luminescent dosimeters were used to calculate the changes in effective or equivalent doses to 9 anatomic structures through the addition of a thyroid collar, radiation safety glasses, and a radiation safety cap and by using different scanning protocols on a CS 9300 CBCT unit. RESULTS: The thyroid collar alone yielded dose reductions of 46% to the thyroid gland and at least 38% to the esophagus, but no more than 12% to the salivary glands. The radiation safety cap significantly reduced doses to the brain and the pituitary gland. Full shielding resulted in dose reductions of at least 50% to the thyroid gland, at least 47% to the esophagus, and approximately 35% to the brain and the pituitary gland. Significant dose reductions were recorded for all tissues with the "low dose" setting compared with the standard setting. CONCLUSIONS: Increased protection of the organs in the head and neck regions can be achieved by using various forms of shielding in CBCT imaging, with selection of the most appropriate scanning parameters based on the purpose of the examination.
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Tomografía Computarizada de Haz Cónico , Dosimetría Termoluminiscente , Cabeza , Masculino , Fantasmas de Imagen , Dosis de RadiaciónRESUMEN
Complications in orthognathic surgery are commonly a result of inadequate preoperative planning and communication between the surgeon and orthodontist. Unfavorable outcomes can often be avoided when overall treatment goals along with a surgical and orthodontic plan are developed and agreed upon by the orthodontist, surgeon, and patient before the start of active tooth movement or any surgical procedures. Continuous evaluation of the patient's progress throughout treatment and subsequent communication between the surgeon and orthodontist are recommended to prevent frequent errors, such as inadequate dental decompensation, poor appliance selection or management, and occasional contraindicated orthodontic elastic traction or tooth movements.
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Maloclusión , Ortodoncia Correctiva/métodos , Ortodoncia , Cirugía Ortognática/métodos , Procedimientos Quirúrgicos Ortognáticos/métodos , Planificación de Atención al Paciente , Humanos , Grupo de Atención al Paciente , Complicaciones PosoperatoriasRESUMEN
OBJECTIVES: To determine the relationship between traditional cephalometric measurements and corresponding nonradiographic three-dimensional (3D) photogrammetry measurements. MATERIALS AND METHODS: This was a cross-sectional study of 20 orthodontic patients (10 male and 10 female) who received lateral cephalometric radiographs and 3D dentofacial photogrammetric records with each subject serving as his or her own control for a total sample size of 40 images (20 per method). A 3D analysis that resembled a traditional cephalometric analysis was established using the eyes and natural head orientation as substitutes for the cranial base. Pearson correlation coefficients and multivariable linear regression plots were calculated to evaluate the relationship between the photogrammetry measurements and the cephalometric measurements. RESULTS: The ANB angle, mandibular plane angle, lower anterior face height, upper incisor angle to SN, upper incisor angle to NA, and all measurements of lower incisor position and inclination had strong positive Pearson correlation coefficients with the corresponding 3D photogrammetry measurements ( P < .004). Statistically significant regression plots demonstrated that cephalometric relationships between the jaws and incisor orientation can be predicted from corresponding 3D photogrammetry measurements. CONCLUSIONS: 3D photogrammetry measurements relating the jaws to each other and incisor orientation has a strong positive correlation with corresponding traditional cephalometric measurements and can serve as cephalometric predictors. Capturing the eyes using 3D photogrammetry can obviate the need to expose the cranial base and allow limiting the radiographic field to the area of interest.
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Cefalometría , Incisivo , Fotogrametría , Cefalometría/métodos , Estudios Transversales , Femenino , Humanos , Masculino , Radiografía DentalRESUMEN
OBJECTIVE: To correlate traditional Steiner's skeletal and dental measurements to similar measurements that use the eyes and natural head position as references instead of the cranial base. SETTING AND SAMPLE: One hundred and fifty-two lateral cephalometric radiographs (66 female and 86 male) from the Harvard Forsyth twin sample were included in the study based on record availability. MATERIAL AND METHODS: This was an observational study in which all cephalometric radiographs were traced and analysed using Steiner's cephalometric analysis. Each cephalogram was then altered to perform a similar analysis that uses the maximum convexity of the cornea together with natural head position as references instead of the cranial base. A Pearson product-moment correlation coefficient was measured to determine the correlation between the conventional Steiner's analysis measurements and the novel measurements relying on the eyes and natural head position. RESULTS: Steiner's cephalometric measurements of the jaws to each other, the divergency and the orientation of the incisors had a strong positive correlation with their counterparts that relied on true horizontal and/or the eyes (P < 0.001). CONCLUSION: The eyes and true horizontal can be used as alternatives to the cranial base when diagnosing the relationship between the jaws and the position and orientation of the teeth. Since the eyes and natural head position are identifiable without ionizing radiation, future research should focus on the use of radiographic exposures limited to the upper and lower jaws for orthodontic diagnosis and outcome assessment.
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Cefalometría/métodos , Base del Cráneo/anatomía & histología , Adolescente , Niño , Ojo/anatomía & histología , Cabeza/anatomía & histología , Humanos , Maxilares/anatomía & histología , Masculino , Variaciones Dependientes del Observador , Reproducibilidad de los Resultados , Base del Cráneo/diagnóstico por imagenRESUMEN
INTRODUCTION: Cephalometrics has been the foundation of orthodontic diagnosis for many years. However, for many orthodontic patients, a lateral cephalogram might not be necessary. The aim of this study was to compare the diagnosis and treatment planning agreement between standard records and nonradiographic 3-dimensional (3D) dentofacial photogrammetry records. METHODS: Twenty patients had standard orthodontic records taken for their treatment as well as extraoral and intraoral 3D images. Twelve evaluators examined the standard records and then completed diagnosis and treatment planning questionnaires. They repeated the process 4 to 6 weeks later by using 3D photographic images along with the panoramic radiographs. Each evaluator also evaluated 2 random orthodontic cases twice with each method to evaluate consistency within each method. At the end of study, each evaluator was asked to complete a survey to document his or her experiences with the 3D photogrammetry method. Descriptive and kappa statistics were used to determine the agreement. RESULTS: Most diagnosis parameters had fair agreement between the methods and within each method. Skeletal and dental relationships had excellent agreement between and within the methods as well as most treatment decisions such as the need for extractions and surgery. Most evaluators (91.7%) thought that cephalometric x-rays would be needed only some of the time in diagnosis and treatment planning. Most evaluators (83.33%) thought that cephalometric radiographs are not needed in patients with a Class I ± a quarter cusp with crowding or spacing. CONCLUSIONS: Most diagnostic decisions had fair agreement within and between the 2 methods. The decision to extract and the need for orthognathic surgery had excellent agreement between the cephalometric and photogrammetric methods. The majority of examiners agreed that patients with Class I malocclusions ± a quarter cusp with no obvious skeletal discrepancy can be diagnosed and planned without a cephalometric radiograph.
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Cefalometría , Imagenología Tridimensional , Maloclusión Clase I de Angle/diagnóstico por imagen , Maloclusión/terapia , Ortodoncia Correctiva , Planificación de Atención al Paciente , Adolescente , Adulto , Puntos Anatómicos de Referencia , Niño , Toma de Decisiones , Femenino , Humanos , Masculino , Modelos Dentales , Radiografía PanorámicaRESUMEN
Background: Orthodontic diagnostic standards generally use the cranial base as a reference and rely on samples selected by orthodontists. Objective: The purpose of this study was to provide male and female standards for a novel non-radiographic approach for orthodontic diagnosis that utilizes 3D dentofacial photogrammetry using the eyes and natural head orientation as references instead of the cranial base. Methods: One hundred and eighty females and 200 males between the ages of 18 and 35 years from 2 modeling agencies were orthodontically screened for near ideal occlusion. Subjects that met the inclusion criteria were rated by a sample of 40 lay people for attractiveness on a visual analogue scale. The final sample that had 3D facial and dental imaging included 49 subjects 25 males and 24 females with near ideal occlusion and considered attractive by the public. Results: Inter and Intra-examiner ICC were greater than 0.8 for both landmarking and indexing. Relative to a coronal plane contacting the pupils (MC), the mean sagittal position of the alar curvature (representing the nasomaxillary complex) was 14.36 ± 3.08 mm in males and 12.4 ± 3.58 mm in females. The sagittal position of soft tissue pogonion relative to the pupils was 14.84 ± 3.63 mm in males and 12.78 ± 5.68 mm in females. The angle between the alar curvature and pogonion relative to the pupils was 9° in males and 10° in females. With the exception of the occlusal plane which was steeper in females, no ratios or angular facial measurements showed a significant gender difference. Relative to MC, males had more proclined upper incisors (20° vs 16°) and more retroclined Lower incisors (27° vs 31°; P > 0.05). A Procrustes ANOVA and permutation test showed that the shapes of males and females are different enough to be considered two distinct populations. Conclusions: 1. When using the proposed method for orthodontic diagnosis, male and female patients should be compared to their respective dentofacial standards. 2. Validation of the proposed method and standards on an orthodontic population is underway to determine the scope its use.
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Maloclusión/diagnóstico , Fotogrametría/métodos , Fotografía Dental/métodos , Adolescente , Adulto , Cefalometría/métodos , Cara/anatomía & histología , Femenino , Humanos , Incisivo/anatomía & histología , Masculino , Maloclusión/terapia , Variaciones Dependientes del Observador , Ortodoncia Correctiva , Valores de Referencia , Caracteres Sexuales , Adulto JovenRESUMEN
INTRODUCTION: We systematically reviewed observational, experimental, and diagnostic accuracy studies to assess the comparisons between cone-beam computed tomography (CBCT) and conventional radiography (CR) in the localization of maxillary impacted canines. METHODS: An open-ended electronic search of PubMed, Web of Science, ProQuest, and other databases for both published and unpublished articles up to May 2016 was performed. The reference lists of the included studies were screened. Two authors performed the searches with no language restrictions. The research questions were outlined based on a hierarchical model. The primary outcomes were diagnostic accuracy, level of intermodalities agreement, effect of these images on treatment planning and treatment outcomes, and societal efficacy between the CBCT and CR in the localization of impacted canines. Two reviewers evaluated the risk of bias assessment by using the Quality Assessment of Diagnostic Accuracy Studies tool and the Newcastle Ottawa Scale. RESULTS: Eight studies met the inclusion criteria. Two studies reported diagnostic accuracy, 6 reported intermodalities agreement in impacted canine localization, and 3 reported treatment planning agreement between the modalities. No therapeutic and societal efficacy study found. The accuracy of CBCT ranged from 50% to 95%, and the accuracy of CR ranged from 39% to 85%. A wide range of kappa intermodalities agreement from 0.20 to 0.82, with observed agreement of 64% to 84%, was reported in canine localization. Broad kappa treatment planning agreement values from 0.36 to 0.72 were reported. Most studies suffered from a high risk of bias in subject selection. CONCLUSIONS: The fair to moderate intermodalities agreement in maxillary canine localization might mean that the information obtained through these modalities is deviant and ultimately might affect treatment planning. Although there is still a lack of strong evidence, CBCT is more effective than CR in evaluating cases that are difficult to diagnose in the initial evaluation with CR. FUNDING: No funding was received for this study.
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Tomografía Computarizada de Haz Cónico , Diente Canino/diagnóstico por imagen , Radiografía , Diente Impactado/diagnóstico por imagen , Humanos , MaxilarRESUMEN
OBJECTIVE: To systematically review the literature correlating upper airway parameters between lateral cephalograms (LC) and cone-beam computed tomography (CBCT) or computed tomography (CT) scans to determine the utility of using LC to predict three-dimensional airway parameters. MATERIALS AND METHODS: Both electronic and manual searches of the included studies were performed by two reviewers, and the quality of the studies that met selection criteria were assessed. RESULTS: A total of 11 studies from the literature met the selection criteria. Assessed outcome variables showed correlation r < .7 between the LC and CT scans. The correlation between the LC and CBCT ranged from weak to strong with -.78 ≤ r and r ≤ .93 reported in the nasopharyngeal segment. In the oropharyngeal segment, a weak to strong correlation was reported with a range of -37 ≤ r and r ≤ .83 between the CBCT and LC. All associations in the hypopharyngeal segment showed a weak correlation. Four of studies were of weak quality, five were of moderate quality, and two were rated to be of strong quality. CONCLUSION: No strong correlations were reported between the LC and CT scans. However, the LC-derived adenoid-nasopharyngeal ratio and the linear measurement (posterior nasal spine, PNS, to posterior pharyngeal wall) had a strong correlation with upright nasopharyngeal area and volume in the CBCTs. The area measurement in conventional LC can be also used as an initial screening tool to predict the upright three-dimensional oropharyngeal volumetric data. The variability of the hypopharyngeal segment cannot be predicted by LCs. However, more well-designed studies are needed to determine the clinical utility of using LC to predict airway size.
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Cefalometría/métodos , Tomografía Computarizada de Haz Cónico/métodos , Imagenología Tridimensional/métodos , Faringe/diagnóstico por imagen , Tonsila Faríngea/diagnóstico por imagen , Humanos , Hipofaringe/diagnóstico por imagen , Procesamiento de Imagen Asistido por Computador/métodos , Nasofaringe/diagnóstico por imagen , Orofaringe/diagnóstico por imagen , Radiografía/métodosRESUMEN
BACKGROUND: The objective of this study was to evaluate long-term clinical and bacterial effects of using 6 g of xylitol per day for 3 months on patients with full fixed orthodontic appliances. METHODS: The study was a pilot clinical trial that included 41 subjects who were undergoing orthodontic treatment. The subjects were randomly divided into three groups. Group A received xylitol chewing gum, group B received xylitol dissolvable chewable tablets, and Group C served as the control group and did not receive xylitol gums or tablets. Clinical examination and the collection of plaque and saliva samples were carried out at baseline and 3, 6, and 12 months. All three groups were given oral hygiene instruction and were put on a 6-month cleaning and topical fluoride schedule. Plaque scores and bacterial counts were used to evaluate the effectiveness of the different approaches at reducing the caries risk. RESULTS: Xylitol groups did not experience any more reduction in plaque score, plaque MS counts, or salivary MS counts than the control group nor did they have lower values at any of the time points. Chewing gum did not significantly increase the incidence of debonded brackets over the other groups. CONCLUSIONS: Xylitol does not have a clinical or bacterial benefit in patients with fixed orthodontic appliances. Oral hygiene instructions and 6-month topical fluoride application were effective at reducing plaque scores and bacterial counts in patients with full fixed appliances regardless of whether or not xylitol was used.
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Placa Dental/prevención & control , Soportes Ortodóncicos/microbiología , Streptococcus mutans/efectos de los fármacos , Xilitol/uso terapéutico , Adolescente , Adulto , Carga Bacteriana/efectos de los fármacos , Cariostáticos/uso terapéutico , Goma de Mascar , Niño , Caries Dental/microbiología , Caries Dental/prevención & control , Placa Dental/microbiología , Índice de Placa Dental , Profilaxis Dental/métodos , Femenino , Fluoruros Tópicos/uso terapéutico , Estudios de Seguimiento , Humanos , Estudios Longitudinales , Masculino , Higiene Bucal/educación , Proyectos Piloto , Saliva/efectos de los fármacos , Saliva/microbiología , Comprimidos , Xilitol/administración & dosificación , Adulto JovenRESUMEN
BACKGROUND: Facial growth in the vertical dimension is the last to be completed and can often be detrimental to the success of dental implants, orthodontic treatment, and orthognathic surgery that young individuals undergo. AIM: The purpose of this study was to evaluate the longitudinal relationship between changes in total anterior facial height and insulin-like growth factor-1 (IGF-1) levels measured using blood-spot samples. METHODS: Our sample included 25 orthodontic patients from whom we had access to annual lateral cephalometric radiographs and IGF-1 measurements. Each subject was observed between 2 and 6 times, resulting in 43 annual intervals from a total of 77 observations. RESULTS: We noted a significant moderate positive correlation (+ 0.48) between the percentage of change in blood-spot IGF-1 levels and the percentage of change in total anterior face height (p = 0.01). CONCLUSION: Longitudinal changes in IGF-1 levels can be used to predict a patient's vertical facial growth. There was no significant correlation between changes in vertical facial development and a single cross-sectional IGF-1 measurement.
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Envejecimiento/sangre , Cara/diagnóstico por imagen , Factor I del Crecimiento Similar a la Insulina/metabolismo , Desarrollo Maxilofacial/fisiología , Radiografía Dental/métodos , Dimensión Vertical , Adolescente , Envejecimiento/fisiología , Cefalometría/métodos , Niño , Cara/anatomía & histología , Femenino , Humanos , Factor I del Crecimiento Similar a la Insulina/análisis , Estudios Longitudinales , Masculino , Reproducibilidad de los Resultados , Sensibilidad y Especificidad , Adulto JovenRESUMEN
BACKGROUND: The purpose of this study was to predict the annual growth rate of the mandible and total anterior facial height using IGF-1 levels together with cervical stage, skeletal classification, and gender. METHODS: Twenty-five orthodontic patients (12 females and 13 males) had their cervical stages, blood-spot IGF-1 levels, and cephalometric parameters measured at 1-year intervals. The number of years each patient was followed up varied between 1 and 5 years resulting in 43 12-month intervals collected from 77 observations. Descriptive, bivariate, and regression analyses were used to analyze this data. RESULTS: The linear regression model for predicting the annual mandibular growth rate was significant at p < 0.01 with an R-square value of 0.52. We found that the average IGF-1 level for the interval, the change in IGF-1 level, and the presence of a skeletal class III pattern were statistically significant predictors of mandibular growth. The regression model for predicting the annual change in anterior facial height was significant at p < 0.01 with an R-square value of 0.42. We found that the change in IGF-1 level was the only statistically significant predictor of this outcome. CONCLUSIONS: The proposed method which combines IGF-1 levels with information that is readily available to clinicians can be used to predict the timing and intensity of the growth spurt. These factors together explain more of the observed individual variation in growth rate than any of the factors used in isolation.
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Determinación de la Edad por el Esqueleto/métodos , Vértebras Cervicales/crecimiento & desarrollo , Factor I del Crecimiento Similar a la Insulina/análisis , Mandíbula/crecimiento & desarrollo , Dimensión Vertical , Adolescente , Niño , Femenino , Estudios de Seguimiento , Predicción , Humanos , Masculino , Maloclusión Clase II de Angle/patología , Maloclusión Clase II de Angle/fisiopatología , Maloclusión de Angle Clase III/patología , Maloclusión de Angle Clase III/fisiopatología , Mandíbula/anatomía & histología , Factores SexualesRESUMEN
INTRODUCTION: The Food and Drug Administration Modernization Act of 1997 made it mandatory for all phase II through IV trials regulated by this Act to be registered. After this, the National Institutes of Health created ClinicalTrials.gov, which is a registry of publicly and privately supported clinical studies of human participants. The objective of this study was to examine the characteristics of registered studies in orthodontics. METHODS: The ClinicalTrials.gov Web site was used to query all registered orthodontic studies. The search term used was "orthodontics." No limitations were placed for the time period. All registered studies regardless of their recruitment status, study results, and study type were selected for analysis. RESULTS: A total of 64 orthodontic studies were registered as of January 1, 2014. Of these, 52 were interventional, and 12 were observational. Close to 60% of the interventional studies and 66.7% of the observational studies had sample sizes of 50 or fewer subjects. About 21.2% of the interventional studies and 16.7% of the observational studies had sample sizes greater than 100. Only 1 study was funded by the National Institutes of Health, and the rest were funded by "other" or "industry" sources. Close to 87.7% of the interventional studies were randomized. Interventional model assignments included factorial assignment (3.9%), parallel assignments (74.5%), crossover assignment (7.8%), and single-group assignment (13.7%). Most studies were treatment oriented (80.4%). The types of masking used by the interventional studies included open label (28.9%), single blind (44.2%), and double blind (26.9%). Outcome assessors were blinded in only 6 studies. CONCLUSIONS: Orthodontic studies registered in ClinicalTrials.gov are dominated by small single-center studies. There are wide variations with regard to treatment allocation approaches and randomization methods in the studies. These results also indicate the need for multicenter clinical studies in orthodontics.
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Ensayos Clínicos como Asunto , Ortodoncia , Sistema de Registros , Adulto , Factores de Edad , Niño , Estudios Cruzados , Bases de Datos Factuales , Método Doble Ciego , Femenino , Humanos , Masculino , National Institutes of Health (U.S.) , Estudios Observacionales como Asunto , Ensayos Clínicos Controlados Aleatorios como Asunto , Proyectos de Investigación , Apoyo a la Investigación como Asunto , Tamaño de la Muestra , Factores Sexuales , Método Simple Ciego , Estados Unidos , United States Food and Drug Administration/legislación & jurisprudenciaRESUMEN
AIM: This case report describes the treatment of a patient of African descent with bilateral congenitally missing mandibular incisors and a 10 mm overjet. METHODS: The article discusses the incidence of tooth agenesis and the different approaches to treating patients with bilateral congenitally missing lower incisors. The current treatment involved lower canine substitution for the lower lateral incisors and upper premolar extractions because of malformation. Temporary micro-implants were placed to augment anchorage and to resolve the excessive overjet by the retraction of the upper anterior teeth while preserving a Class I molar relationship. RESULTS: The Bolton disharmony created by the incisor agenesis and the extraction pattern proved to be a challenge and although an acceptable result was achieved, it was expectedly less than ideal.
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Anodoncia/terapia , Incisivo/anomalías , Sobremordida/terapia , Adolescente , Diente Premolar/cirugía , Diente Canino/patología , Implantes Dentales , Femenino , Humanos , Mandíbula/patología , Maxilar/patología , Miniaturización , Métodos de Anclaje en Ortodoncia/instrumentación , Planificación de Atención al Paciente , Extracción Dental , Técnicas de Movimiento Dental/instrumentación , Técnicas de Movimiento Dental/métodosRESUMEN
INTRODUCTION: The purpose of this study was to develop the use of a biologic marker, insulin-like growth factor (IGF-1), as an indicator for the timing and intensity of mandibular growth. This was done by measuring annual changes in mandibular length and studying how they relate to blood-spot IGF-1 measurements and cervical stages. METHODS: Twenty-five patients (12 female, 13 male) from an orthodontic population were longitudinally evaluated for annual IGF-1 level, cervical stage, and mandibular length. The patients' follow-up periods ranged between 1 and 5 years. A total of 43 annual time intervals were gathered (17 female, 26 male). Annual mandibular growth was related to changes in blood-spot IGF-1 levels over each observation period. RESULTS: When the whole sample was pooled into 1 group, we found a statistically significant mild to moderate correlation between the percentages of change in mandibular length and in IGF-1 levels (r = 0.4, P = 0.008). When the sample was divided based on whether the IGF-1 levels were increasing or decreasing at each yearly interval, the group with ascending IGF-1 levels had significantly more mandibular growth than did the group with descending IGF-1 levels (3.5 and 1.3 mm, respectively; P = 0.026). The ascending group had a moderate to high correlation between average IGF-1 levels and the amount of mandibular growth for each observation period. Observation periods with ascending IGF-1 levels and an average level greater than 250 µg per liter had significantly greater annual mandibular growth than did the rest of the patients with ascending IGF-1 levels (5.6 and 2.1 mm, respectively). CONCLUSIONS: Blood-spot IGF-1 testing is a promising tool for predicting the timing and the intensity of the mandibular growth spurt without the restrictions involved with radiographic techniques for assessing skeletal maturity. More research is necessary to validate these results in a different population by using more advanced imaging tools and a larger sample size. The relationship between IGF-1 levels and mandibular growth after the pubertal growth spurt is not fully understood.
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Factor I del Crecimiento Similar a la Insulina/análisis , Mandíbula/crecimiento & desarrollo , Adolescente , Cefalometría , Vértebras Cervicales/crecimiento & desarrollo , Niño , Pruebas con Sangre Seca , Femenino , Humanos , Masculino , Estudios Prospectivos , Estadísticas no ParamétricasRESUMEN
INTRODUCTION: Accurate prediction of the timing of the pubertal growth spurt and the amount of remaining growth are factors that affect treatment decisions in orthodontics, orthognathic surgery, and dental implantology. For many years, medical and dental professionals have considered hand-wrist radiographs the method of choice for the assessment of skeletal maturity. Insulin-like growth factor 1 (IGF-1) mirrors growth hormone levels and is used by endocrinologists to diagnose growth hormone disturbances. METHODS: The objective of this study was to establish a relationship between IGF-1 levels collected from blood-spot samples and hand-wrist radiographs at various skeletal stages. Eighty-four subjects (45 female, 39 male) between the ages of 5 and 25 were included in the study. Each subject had personal information, a hand-wrist radiograph, and a blood-spot sample collected on the same day. RESULTS: The IGF-1 levels were highest at the hand-wrist skeletal stages that were previously associated with the greatest amount of mandibular growth. These levels were significantly higher than at prepubertal and postpubertal stages. In the postpubertal group, the IGF-1 levels were lower as the subjects' ages increased and they moved away from the onset of puberty. CONCLUSIONS: Longitudinal data are necessary to confirm the usefulness of this technique in predicting the timing, the intensity, and the end of the growth spurt.