RESUMEN
PurposePhaeohyphomycosis are melanin-containing fungi that rarely infect the eye. We describe three cases of ocular infection with some unusual clinical features.MethodsSeries of three case reports describing three different presentations of phaeohyphomycosis of the eye, their histopathology, and management.ResultsCase 1 mimicked an inflamed conjunctival naevus and was excised on this basis, revealing a conjunctival retention cyst containing pigmented fungal hyphae. Case 2 showed a wooden foreign body incidentally associated with pigmented fungal hyphae, which required treatment with topical antifungal therapy. Case 3 clinically was thought to be a perforated uveal melanoma and comprised an extensive plaque of pigmented fungal hyphae over ulcerated cornea.ConclusionThe pigmented melanin containing hyphae of phaeohyphomycosis mimicked melanocytic lesions in two cases and was an incidental finding in the context of a surface foreign body.
Asunto(s)
Enfermedades de la Conjuntiva/diagnóstico , Úlcera de la Córnea/diagnóstico , Quistes/diagnóstico , Cuerpos Extraños en el Ojo/diagnóstico , Infecciones Fúngicas del Ojo/diagnóstico , Granuloma de Cuerpo Extraño/diagnóstico , Feohifomicosis/diagnóstico , Adulto , Antifúngicos/uso terapéutico , Niño , Enfermedades de la Conjuntiva/tratamiento farmacológico , Enfermedades de la Conjuntiva/microbiología , Úlcera de la Córnea/tratamiento farmacológico , Úlcera de la Córnea/microbiología , Quistes/tratamiento farmacológico , Quistes/microbiología , Diagnóstico Diferencial , Cuerpos Extraños en el Ojo/tratamiento farmacológico , Cuerpos Extraños en el Ojo/microbiología , Infecciones Fúngicas del Ojo/tratamiento farmacológico , Infecciones Fúngicas del Ojo/microbiología , Femenino , Granuloma de Cuerpo Extraño/tratamiento farmacológico , Granuloma de Cuerpo Extraño/microbiología , Humanos , Masculino , Persona de Mediana Edad , Feohifomicosis/tratamiento farmacológico , Feohifomicosis/microbiología , Voriconazol/uso terapéuticoRESUMEN
BACKGROUND: Metastasis to choroid is the most common intraocular malignancy, arising most frequently from carcinoma of breast in women and lung in men. Recent case reports have described successful use of intravitreal bevacizumab to achieve local control of such tumours. MATERIALS AND METHODS: Five cases of choroidal metastases from varying primaries: breast, lung, and colon were treated with intravitreal bevacizumab, and tumour response observed and documented with serial photographs and B-scans. RESULTS: Four of the five tumours were seen to progress despite intravitreal bevacizumab treatment. CONCLUSIONS: Intravitreal bevacizumab as the primary treatment of choroidal metastases is not recommended and should not delay more effective alternative treatments.
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Adenocarcinoma/tratamiento farmacológico , Inhibidores de la Angiogénesis/uso terapéutico , Bevacizumab/uso terapéutico , Carcinoma/tratamiento farmacológico , Neoplasias de la Coroides/tratamiento farmacológico , Neoplasias Intestinales/patología , Adenocarcinoma/secundario , Adulto , Anciano de 80 o más Años , Neoplasias de la Mama/patología , Carcinoma/secundario , Ciego , Neoplasias de la Coroides/secundario , Femenino , Angiografía con Fluoresceína , Humanos , Inyecciones Intravítreas , Neoplasias Pulmonares/patología , Masculino , Persona de Mediana Edad , Tomografía de Coherencia Óptica , Insuficiencia del Tratamiento , Factor A de Crecimiento Endotelial Vascular/antagonistas & inhibidores , Agudeza VisualRESUMEN
PURPOSE: Malignant melanoma of the eye is an uncommon condition that is important to recognise. We describe three cases in which ocular foreign bodies have masqueraded as ocular malignant melanoma. METHODS: Interventional case reports. RESULTS: Case 1 describes diathermy-induced carbon particle implantation, during plaque therapy for the treatment of uveal melanoma, mimicking recurrence with extra-scleral invasion. Case 2 shows a foreign body called 'mullite' mimicking conjunctival melanoma. Case 3 demonstrates a conjunctival foreign body called 'illite' that mimicked a limbal melanocytic lesion, clinically thought to be either melanocytoma or melanoma. CONCLUSION: This report highlights the importance of careful history taking, examination, and appropriate biopsy in cases of suspected malignant melanoma, to prevent unnecessary and potentially radical treatment.
Asunto(s)
Conjuntiva/lesiones , Neoplasias de la Conjuntiva/diagnóstico , Cuerpos Extraños en el Ojo/diagnóstico , Lesiones Oculares/diagnóstico , Melanoma/diagnóstico , Heridas no Penetrantes/diagnóstico , Adulto , Silicatos de Aluminio/análisis , Carbono/análisis , Conjuntiva/química , Diagnóstico Diferencial , Femenino , Humanos , Masculino , Persona de Mediana Edad , Minerales/análisis , Espectrometría por Rayos XRESUMEN
PURPOSE: The purpose of this study was to improve communication between the ophthalmology and histopathology departments at Royal Hallamshire Hospital, Sheffield, by effectively changing the structure and completion of the histopathology request form through the process of a successful audit. This aimed to ensure that comprehensive information was made available to the histopathologist. METHODS: An audit was performed by review of 710 histopathology request forms, completed by the ophthalmology department, over a 1-year period, between July 2005 and June 2006 inclusive. Results were used to re-model the ophthalmic histopathology request form. New forms were circulated and all forms completed over a 3-month period, between January 2008 and March 2008, were reviewed, thus closing the audit loop. RESULTS: On the basis of audit results of 710 histopathology request forms, a new histopathology request form was created, which was easier to complete. Review of the 224 new histopathology request forms showed improved percentages of completion of important sections of the form. CONCLUSIONS: Through the audit process we have created a new ophthalmic histopathology request form that is more user-friendly for the ophthalmologist and more consistently provides the necessary information for the ophthalmic histopathologist. This has improved efficiency and effectiveness of communication between the specialities, which should contribute to minimise the chances of medical error and improved turnaround times for the planning and delivery of patient care.