RESUMEN
BACKGROUND AND METHODS: After an increase in the number of cases of tuberculosis, New York City passed regulations to address the problem of nonadherence to treatment regimens. The commissioner of health can issue orders compelling a person to be examined for tuberculosis, to complete treatment, to receive treatment under direct observation, or to be detained for treatment. On the basis of a review of patients' records, we evaluated the use of these legal actions between April 1993 and April 1995. RESULTS: Among more than 8000 patients with tuberculosis, regulatory orders were issued for less than 4 percent. Among patients with a variety of social problems, only a minority required regulatory intervention: 10 percent of those with injection-drug use, 16 percent of those with alcohol abuse, 17 percent of those who were homeless, 29 percent of those who used "crack" cocaine, and 38 percent of those with a history of incarceration. A total of 150 patients were ordered to undergo directly observed therapy, 139 patients to be detained during therapy, 12 patients to be examined for tuberculosis, and 3 patients to complete treatment. These 304 patients had a median of three prior hospitalizations related to tuberculosis and one episode of leaving the hospital against medical advice. Repeatedly noncompliant patients and those who left the hospital against medical advice were more likely than others to be detained. The median length of detention was 3 weeks for infectious patients and 28 weeks for noninfectious patients. As compared with patients ordered to receive directly observed therapy, the patients who were detained remained infectious longer, had left hospitals against medical advice more often, and were less likely to accept directly observed therapy voluntarily. Altogether, excluding those who died or moved, 96 percent of the patients completed treatment, and 2 percent continued to receive treatment for multidrug-resistant tuberculosis. CONCLUSIONS: For most patients with tuberculosis, even those with severe social problems, completion of treatment can usually be achieved without regulatory intervention. Patients were detained on the basis of their history of tuberculosis, rather than on the basis of their social characteristics, and the less restrictive measure of mandatory directly observed therapy was often effective.
Asunto(s)
Control de Enfermedades Transmisibles/legislación & jurisprudencia , Control Social Formal , Negativa del Paciente al Tratamiento/legislación & jurisprudencia , Tuberculosis Pulmonar/tratamiento farmacológico , Adolescente , Adulto , Anciano , Control de Enfermedades Transmisibles/métodos , Femenino , Agencias Gubernamentales/legislación & jurisprudencia , Personas con Mala Vivienda/estadística & datos numéricos , Humanos , Gobierno Local , Masculino , Persona de Mediana Edad , Ciudad de Nueva York/epidemiología , Cooperación del Paciente/estadística & datos numéricos , Estudios Retrospectivos , Trastornos Relacionados con Sustancias/epidemiología , Tuberculosis/tratamiento farmacológico , Tuberculosis/epidemiología , Tuberculosis Pulmonar/epidemiología , Tuberculosis Pulmonar/prevención & controlRESUMEN
OBJECTIVE: To investigate a multi-institutional outbreak of highly resistant tuberculosis and evaluate patient outcome. DESIGN: Epidemiologic investigation of every tuberculosis case reported in New York City. SETTING: Patients cared for at all public and nonpublic institutions from January 1, 1990, to August 1, 1993 (43 months). PATIENTS: We reviewed medical and public health records and conducted clinical, epidemiologic, drug susceptibility, and restriction fragment length polymorphism (RFLP) analyses. A case was defined as tuberculosis in a patient with an isolate resistant to isoniazid, rifampin, ethambutol hydrochloride, and streptomycin (and rifabutin, if sensitivity testing included it), and, if RFLP testing was done, a pattern identical to or closely related to strain W. MAIN OUTCOME MEASURES: Patient survival and the conversion of sputum cultures from positive to negative. RESULTS: Of the 357 patients who met the case definition, 267 had identical or nearly identical RFLP patterns; isolates from the other 90 patients were not available for RFLP testing. Among these 267 patients, 86% were human immunodeficiency virus (HIV)-infected, 7% were HIV-negative, and 7% had unknown HIV status. All-cause mortality was 83%. Epidemiologic linkages were identified for 70% of patients, of whom 96% likely had nosocomially acquired disease at 11 hospitals. Survival was prolonged among patients who received medications to which their isolate was susceptible, especially capreomycin sulfate, and among patients with a CD4+ T-lymphocyte count greater than 0.200 x 10(9)/L (200/microL). Treatment with isoniazid and a fluoroquinolone antibiotic was also independently associated with longer survival. CONCLUSIONS: This outbreak accounted for nearly one fourth of the cases of multidrug-resistant tuberculosis in the United States during a 43-month period. Most patients had nosocomially acquired disease, were infected with HIV, and unless promptly and appropriately treated, died rapidly. With appropriate directly observed treatment, especially combinations including an injectable medication, even severely immunocompromised patients had culture conversion and prolonged, tuberculosis-free survival.