RESUMEN
Serum copper, ceruloplasmin, protein thiols and thiobarbituric acid reactive substances (TEARS) were estimated in 25 patients of liver cancer. The copper to ceruloplasmin ratio was moderately increased (P<0.05) but the copper (P<0.001) and ceruloplasmin (P<0.001) levels were significantly increased in liver cancer patients when compared to controls. Protein thiols levels were found to be highly significant (P<0.001). Where as the TEARS levels were not found to be significant. Trace elements and free radicals have been implicated in the etiology of cancer. Hence the estimation of ceruloplasmin and protein thiols along with the copper may be of high value in the early diagnosis of cancer.
Asunto(s)
Ceruloplasmina/metabolismo , Cobre/sangre , Neoplasias Hepáticas/sangre , Compuestos de Sulfhidrilo/sangre , alfa-Fetoproteínas/análisis , Ceruloplasmina/análisis , Humanos , Peroxidación de Lípido , Neoplasias Hepáticas/diagnóstico , Persona de Mediana Edad , Sustancias Reactivas al Ácido Tiobarbitúrico/análisis , Sustancias Reactivas al Ácido Tiobarbitúrico/metabolismo , alfa-Fetoproteínas/metabolismoRESUMEN
Serum copper, ceruloplasmin and thiobarbituric acid reactive substances (TBARS) were estimated in 30 patients of ovarian cancer. The copper to ceruloplasmin ratio was moderately increased (P<0.05) but the copper (P<0.01) and ceruloplasmin (P<0.001) levels were significantly increased in ovarian cancer patients as compared to controls. TBARS levels were also found to be highly significant (P<0.001). Trace elements and free radicals have been implicated in the etiology of cancer. Hence the estimation of antioxidants like ceruloplasmin and TBARS along with the trace element like copper may be of value in the early diagnosis of cancer.
Asunto(s)
Humanos , Neoplasias Ováricas , Cobre , Sustancias Reactivas al Ácido Tiobarbitúrico , CeruloplasminaRESUMEN
Serum copper, ceruloplasmin and thiobarbituric acid reactive substances (TBARS) were estimated in 30 patients of ovarian cancer. The copper to ceruloplasmin ratio was moderately increased (P<0.05) but the copper (P<0.01( and ceruloplasmin (P<0.001) levels were significantly increased in ovarian cancer patients as compared to controls. TBARS levels were also found to be highly significant (P<0.001). Trace elements and free radicals have been implicated in the etiology of cancer. Hence the estimation of antioxidants like ceruloplasmin and TBARS along with the trace element like copper may be of value in the early diagnosis of cancer.