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Bioorg Med Chem Lett
; 20(16): 4812-5, 2010 Aug 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-20638281
RESUMEN
The syntheses and structure-activity relationships of the tartrate-based TACE inhibitors are discussed. The optimization of both the prime and non-prime sites led to compounds with picomolar activity. Several analogs demonstrated good rat pharmacokinetics.