[Radioimmunotherapy: current state of the problem].

This review presents modern data about one of the promising direction in treatment of malignancies, which is called radioimmunotherapy. The special attention is paid to search of new targets and development of radiopharmaceuticals that will allow improving quality and accuracy of the directed impact on tumors of various localizations.

[Radionuclide teranostic of malignancies].

This review shows some basic information regarding the relatively new and one of the promising areas, called "theranostics' and also discusses its basic principles. Special attention is paid to the study of approaches in selecting the most appropriate in the application of radioisotopes for solutions appropriate diagnostic and therapeutic applications. Also presented the main directions in the work with monoclonal antibodies and their use in radionuclide theranostics.

[The dynamics of pulse rate and biochemical parameters in blood of healthy individuals in relation to Pc5-6 geomagnetic pulsations].

Four experiments on long-term monitoring of pulse rate and blood biochemical parameters in four healthy volunteers (women) were conducted. The duration of each experiment was 90 minutes, electrocardiography was performed continuously, taking blood sampling every two minutes. In venous blood the current concentrations of triiodothyronine, cortisol, glucose, stable metabolites of nitrogen oxides (NO(x)) were determined. Synchronicity in oscillations of cortisol and free triiodothyronine levels in the blood of all four volunteers was detected, as well as the presence of the periods of 7-8 min and 15-17 min in the spectra of these biochemical parameters was observed. The periods in the spectra of NO(x) are equal to 7 min, 13 min and 25-30 min. It is shown that the, dynamics of variations in the heart rate is determined mostly by the rhythms of fluctuations in the level of NO(x) in the blood, and the periods in wavelet spectra of these physiological parameters in all four volunteers are close to the periods of their spectra synchronous variations of a. geomagnetic field vector in the frequency range of 0.5-3 mHz. The results obtained in this study indicate that. the presence of nitric oxide and its metabolites in the blood is a biochemical factor, with high probability of its participation in the developmental process of the fine "tuning" of the body to the variations of the geomagnetic field providing synchronization of variations in heart rate and geomagnetic fluctuations in the geomagnetic quiet conditions.

[Synchronization in human heart rate dynamics and Pc5 geomagnetic pulsations at different latitudes].

Eight experiments were conducted in synchronized monitoring of cardiac indices in six healthy women at rest simultaneously in three geographic locations--Sofia, Moscow and Arkhangelsk. Comparing spectra of the dynamic time series of the pulse and variations in the horizontal component of the geomagnetic field vector in the frequency range of Pc5 geomagnetic pulsations showed that the main oscillation periods represented in physiological and geophysical time series at each time moment largely coincide. This effect was observed roughly to an equal extent for volunteers who underwent the measurements in all three geographic locations.

[The relation of heart rate variability and a dispersive electrocardiogram mapping indicators in human during fixed rate breathing test].

Association of heart rate variability and dispersive electrocardiogram mapping indicators in women during fixed rate breathing test by the period of 10 s are observed. Disturbance of depolarization processes in auricles that show an increase in dispersive group G1 is associated with expressed vagal reserves deficiency. Intensity of control centralization level by heart rhythm and humoral-metabolic influences both in a background and at active breathing can cause intensifying of high-speed microamplitude characteristics of initial front of ventricles depolarization that reflect an increase of dispersive group G9.

[New remote hybrids between Saccharomyces and Schizosaccharomyces]. / Novye otdalennye gibridy mezhdu Saccharomyces i Schizosaccharomyces.

Crossing the cells of Saccharomyces (diploid) and Schizosaccharomyces (haploid) cells as well as using genetic markers (adenine dependent mutants) and selective media produced remote hybrids. The hybrid cultures possessed the intermediate type of inheritance in a number of properties. Along with budding typical of Saccharomyces, partitions characteristic of Schizosaccharomyces were encountered. The shape and size of cells and some physiological properties were found to vary in the course of vegetative growth (no spores were formed by the hybrid cultures). Conditions are discussed which favour remote hybridization of yeast cultures.