Cursor orientation and computer screen positioning movements.

Implicit directional cues in arrowhead cursors could influence positioning of a cursor on the screen of the computer. Performance during cursor placement may benefit from compatibilities between cursor orientation and direction of movement. Arrowheads could also elicit illusory processes that may affect judgments of (a) the distances on the screen or (b) the location of the point of the arrowhead. To address the impact of the cursor's orientation on its positioning, we had 12 participants move cursors (crosshairs, leftward, or rightward arrow) leftward or rightward to targets (near, far) on a computer screen. Movement amplitude was more important than cursor orientation for initiation of rightward movements, whereas cursor orientation affected the duration of leftward movements and movements to farther targets. Arrowhead orientation contributed to the greater overshooting of far targets. There was little evidence that compatibility of orientation and direction of movement assisted response initiation or execution, and there was little indication that arrowhead cursors led to illusory effects that influenced cursor placement. Arrowhead cursors can provide irrelevant stimulus dimensions that distract users. This work can be applied to the design of cursors in graphical user interfaces. The use of orientation-neutral cursors or cursors whose stimulus dimensions are more relevant is recommended.

Ocular vergence measurement in projected and collimated simulator displays.

The purpose of this study was to investigate electrooculography (EOG) as a measurement of ocular vergence in both collimated and projected simulator environments. The task required participants to shift their gaze between a central fixation point and a target appearing at one of three eccentricities. EOG was effective in recording ocular vergence. The EOG results were similar between collimated and projected displays, except for differences in vergence changes during lateral movement of the eyes, and ocular excursions downward elicited a greater EOG response than the reverse upward movement. The computer-based technique of recording vergence was found to produce measurable traces from a majority of participants. The technique has potential for further development as a tool for measuring ocular vergence in virtual environments where methods that require the wearing of head-mounted apparatus to track ocular structures (e.g., the pupil), which cannot be worn at the same time as a flight or flight-simulator helmet, are unsuitable.

Aurally and visually guided visual search in a virtual environment.

We investigated the time participants took to perform a visual search task for targets outside the visual field of view using a helmet-mounted display. We also measured the effectiveness of visual and auditory cues to target location. The auditory stimuli used to cue location were noise bursts previously recorded from the ear canals of the participants and were either presented briefly at the beginning of a trial or continually updated to compensate for head movements. The visual cue was a dynamic arrow that indicated the direction and angular distance from the instantaneous head position to the target. Both visual and auditory spatial cues reduced search time dramatically, compared with unaided search. The updating audio cue was more effective than the transient audio cue and was as effective as the visual cue in reducing search time. These data show that both spatial auditory and visual cues can markedly improve visual search performance. Potential applications for this research include highly visual environments, such as aviation, where there is risk of overloading the visual modality with information.

Effects of photographs and written descriptors on melanoma detection.

Two studies are reported on the effects of photographic and written information on performance in an experimental melanoma detection task. Subjects were shown slides of four types of skin lesions, including melanoma, and were asked what they would do if the lesion was on their skin. Four response options were provided from seeing a doctor immediately to doing nothing. In Experiment 1, no clear differences in performance were found as a function of prior instruction using four, eight or 16 photographs of each of the four lesion types. In Experiment 2, the effects of written and photographic instructional material were compared. The written material contained descriptions of each lesion type and details of the ABCD criteria for melanoma detection. Eight photographs were provided for each lesion type. Photographic information resulted in superior performance (P < 0.001) for seborrhoeic keratoses and a combination of both types of information was superior (P < 0.05) for melanoma. The two kinds of instructional material produced different effects, suggesting that a brochure offering a combination of photographs and written information is likely to be most useful in helping members of the public identify early melanoma as suspicious.

Effect of felbamate on the pharmacokinetics of lamotrigine.

To assess the possible interaction between lamotrigine and felbamate, a double-blind, randomized, placebo-controlled, two-way crossover study was conducted in 21 healthy male volunteers. Volunteers were given lamotrigine (100 mg every 12 hours) and felbamate (1,200 mg every 12 hours) or matching placebo for 10 days during each period of the crossover. After morning administration on day 10, blood samples were obtained over 12 hours for measurement of lamotrigine. Felbamate increased the maximum concentration (Cmax) and and area under the concentration-time curve from time 0 to 12 hours (AUC0-12) of lamotrigine by 13% and 14%, respectively, compared with placebo. The 90% confidence intervals of the log-transformed pharmacokinetic parameters were within the 80-125% bioequivalance limits, however. Felbamate had no significant effect on the urinary excretion of lamotrigine (total), unconjugated lamotrigine, or the N-glucuronide. One volunteer discontinued the study after developing a rash while taking lamotrigine and placebo. All other adverse events were primarily related to the central nervous system and gastrointestinal tract, with a higher incidence reported during coadministration of lamotrigine and felbamate than with placebo. Overall, felbamate appears to have no clinically relevant effects on the pharmacokinetics of lamotrigine.

Effects of felbamate on the pharmacokinetics of a low-dose combination oral contraceptive.

The effects of felbamate on the pharmacokinetics of a low-dose combination oral contraceptive containing 30 micrograms ethinyl estradiol and 75 micrograms gestodene were assessed in a randomized, double-blind, placebo-controlled parallel-group study in healthy premenopausal female volunteers established in a regimen of oral contraceptive use. They received either placebo or 2400 mg/day felbamate from midcycle (day 15) to midcycle (day 14) of two consecutive oral contraceptive cycles (months 1 and 2). Pharmacokinetic assessments of ethinyl estradiol and gestodene were performed on day 14 of both cycles. To determine whether ovulation occurred, plasma progesterone and urinary luteinizing hormone levels were measured, and diaries recording vaginal bleeding were kept. Felbamate treatment resulted in a significant 42% decrease in gestodene area under the plasma concentration-time curve (0 to 24 hours) (p = 0.018) compared with baseline, whereas a minor but not clinically relevant effect was observed on the pharmacokinetic parameters of ethinyl estradiol. There were no changes in the pharmacokinetics of ethinyl estradiol or gestodene after placebo treatment. No volunteer showed hormonal evidence of ovulation; however, one volunteer reported the onset of intermenstrual bleeding during felbamate treatment. Because of the effect of felbamate on the pharmacokinetics of gestodene and the report of intermenstrual bleeding, it is possible that the contraceptive efficacy of low-dose combination oral contraceptives may be adversely affected during felbamate treatment.

Effects of felbamate on the pharmacokinetics of the monohydroxy and dihydroxy metabolites of oxcarbazepine.

The effects of felbamate on the multiple dose pharmacokinetics of the monohydroxy and dihydroxy metabolites of oxcarbazepine were assessed in a placebo-controlled, randomized, double-blind crossover study in 18 healthy male volunteers. Oxcarbazepine, 1200 mg/day, was administered on an open basis in combination with double-blind placebo or 2400 mg/day felbamate for two 10-day treatment periods separated by a 14-day washout period. Pharmacokinetic parameters of monohydroxyoxcarbazepine and dihydroxyoxcarbazepine were determined from plasma and urine samples obtained on the tenth day of each treatment period. Felbamate had no effect on monohydroxyoxcarbazepine plasma or urine pharmacokinetics compared with placebo, but it significantly increased values for dihydroxyoxcarbazepine maximum concentration and area under the curve from 0 to 12 hours, as well as urinary excretion of free and total dihydroxyoxcarbazepine. The mechanism that may account for the observations is the induction of oxidative metabolism of monohydroxyoxcarbazepine. Despite these changes, the relative amount of dihydroxyoxcarbazepine is small in comparison to monohydroxyoxcarbazepine, and antiepileptic activity is associated with monohydroxyoxcarbazepine rather than dihydroxyoxcarbazepine. Therefore we conclude that felbamate has no clinically relevant effects on the pharmacokinetics of oxcarbazepine in humans.

Effects of felbamate on the pharmacokinetics of phenobarbital.

The effects of felbamate on the pharmacokinetics of phenobarbital and one of its main metabolites, parahydroxyphenobarbital, were assessed in a parallel-group, placebo-controlled, double-blind study, in 24 healthy volunteers. Pharmacokinetic parameters of phenobarbital and parahydroxyphenobarbital were determined from plasma and urine samples obtained after 28 days of daily administration of 100 mg phenobarbital and after a further 9 days of phenobarbital plus 2400 mg/day felbamate or placebo. Felbamate increased phenobarbital values for area under the plasma concentration-time curve from 0 to 24 hours and maximum concentration by 22% and 24%, respectively, whereas placebo had no effect. This increase was caused by a reduction in parahydroxylation of phenobarbital and possibly through effects on other metabolic pathways. Because felbamate inhibits the S-mephenytoin hydroxylase (CYP2C19) isozyme in vitro, it appears that phenobarbital hydroxylation is mediated in part by this isozyme.

Visual accommodation as a cue for size.

Accommodation micropsia is examined in the general context of ocular accommodation as a cue for object size. The nature and limits of accommodation micropsia and arguments dealing with the possible contribution of accommodation to the perception of size are reviewed. Literature on the anomalous myopias, the intermediate-resting hypothesis, and theories of ciliary muscle innervation is examined critically in so far as it bears on the accommodation-micropsia hypothesis. The anomalous myopias and evidence for the intermediate-resting hypothesis are well documented, but without a mechanism for proprioceptive feedback from the ciliary complex about the state of accommodation it can only be concluded that such feedback would have to be indirect, either via the reflex link with vergence, or possibly through the agency of efference-copy neurones.

Visual discrimination of pigmented skin lesions.

Three experiments explored human performance in discrimination of pigmented skin lesions from photographic slides. Experiment 1 showed that latent ability in identifying early melanoma was low, and some benign lesions tended to be falsely identified as serious. Performance overall did not decline when viewing time was reduced, suggesting that judgments could be made on the general appearance of lesions. Experiment 2 showed that enlargement of stimuli had no effect. Experiment 3 showed that performance was better with pictorial examples than with written descriptions for some classes of lesion, but for melanoma performance improved with longer viewing time when information was provided, suggesting that an opportunity to scrutinize could be beneficial. Guidelines to the public should distinguish melanoma from benign lesions and stress the importance of seeking prompt medical attention for suspicious lesions.

Skin examination for signs of cancer.

Doctors sometimes examine or suggest examination of the skin for signs of skin cancer, and self-examination of the skin has been promoted in some public education materials. A representative sample of 590 residents of Victoria was asked whether they or their doctors had ever deliberately checked for signs of skin cancer, and whether their doctors had ever suggested such a check. Respondents also indicated their skin type by degree of freckling and propensity to sunburn. The results suggest that females have a higher level of skin awareness than males. People prone to sunburn and heavily freckled individuals were more likely to have checked their skin, and doctors were more likely to have suggested a check to highly freckled individuals. Self-examination, examination by a doctor and recommendations from doctors for self-examination were all positively associated with each other, indicating that a section of the population was identified by themselves or their doctors as being at risk, but this group was not well defined by the two indices of risk used in the survey.

Pseudophakes experience apparent minification in an imaging display.

Apparent minification of virtual images has been attributed to accommodation micropsia, that is, a reduction in the apparent size of viewed objects accompanying an inward accommodation of the eyes. Thirteen bilateral pseudophakes incapable of accommodation but with good residual vision were tested monocularly for apparent minification in the viewfinder of a single-lens reflex camera. Apparent minification of about the same order as that typically found with normals occurred with the pseudophakic observers, demonstrating that pseudophakes are subject to distortions in apparent size with virtual-imaging displays in the same way as normals, thus establishing that visual accommodation is not a necessary condition for the effect.

Apparent minification in an imaging display under reduced viewing conditions.

When extended outdoor scenes are imaged with magnification of 1 in optical, electronic, or computer-generated displays, scene features appear smaller and farther than in direct view. This has been shown to occur in various periscopic and camera-viewfinder displays outdoors in daylight. In four experiments it was found that apparent minification of the size of a planar object at a distance of 3-9 m indoors occurs in the viewfinder display of an SLR camera both in good light and in darkness with only the luminous object visible. The effect is robust and survives changes in the relationship between object luminance in the display and in direct view and occurs in the dark when subjects have no prior knowledge of room dimensions, object size or object distance. The results of a fifth experiment suggest that the effect is an instance of reduced visual size constancy consequent on elimination of cues for size, which include those for distance.

The effect of accommodation on retinal image size.

The apparent size of an object is diminished when accommodation of the eye moves inward to a position closer to the observer than to a viewed object. This phenomenon is called accommodation micropsia. Using schematic eyes, we investigated change in retinal image size caused by a change in accommodation. The use of schematic eyes is also discussed and is justified. The calculated magnitude of this diminution for four schematic eyes ranged from unity at infinity to a maximum of 0.98 (-2%) at about 12.0 diopters (D). For distances at which accommodation micropsia is typically observed (about 2.0 D), retinal minification is less than 0.997 (-0.3%). Thus changes in the size of the retinal image attributable to accommodation are virtually negligible when compared with the observed reduction of 3% to 33%. This suggests that accommodation micropsia is mediated almost entirely by processes other than those involving the optics of the eye.

Apparent size and distance in an imaging display.

The size-distance invariance hypothesis suggests that the perceived size and the perceived distance of objects in a field viewed naturally are closely related. However, this relationship breaks down when scenes are viewed through high-power optical systems. When natural scenes are viewed through an imaging display of unity magnification, there is a reduction in their apparent size. This raises the question of whether the relationship breaks down when scenes are viewed through a low-power imaging display. A single-lens reflex camera was used as an imaging display that enabled subjects to vary the size of imaged real-world scenes. Judgments of size were found to vary with depth information in scenes and between monocular and binocular viewing, consistent with a previous finding, but judgments of distance did not vary significantly across either of these conditions. The results suggest that judgments of size and judgments of distance with imaging displays are not influenced uniformly by environmental and task variables.