Estudio preliminar de las características del intento de suicidio en la provincia de Granada / Preliminary study of the characteristics of attempted suicide in the province of Granada

Fundamento. Los suicidios en España representan un número de muertes mayor que otras muertes traumáticas. Los comportamientos suicidas no mortales se producen en una proporción mayor que los que tienen fin mortal. Las causas de esta conducta son múltiples y es importante conocerlas para poder prevenirlas. El objetivo del presente trabajo es describir las características del comportamiento suicida no mortal en la provincia de Granada. Método. Estudio descriptivo retrospectivo de las características del comportamiento suicida no mortal en Granada durante los años 2008 y 2009, según la base de datos del Servicio Provincial 061 de Granada. La muestra ha sido todas las demandas realizadas a este servicio en las que en el motivo literal de la alerta figuraron los términos suicidio, autolesióno amenaza suicida. El análisis estadístico se ha realizado con el programa SPSS 15.0. Se analizó la variable conducta suicidano mortal respecto de las variables independientes: sexo, edad, mes, día de la semana, franja horaria, distrito sanitario, resolución de la demanda (prioridad asignada) y reintentos. Resultados. Se analizaron en total 535 demandas tipificadas como lesión autoinflingida intencionalmente por medios no especificados. Se han encontrado diferencias estadísticamente significativas al comparar los datos de los dos años respecto del mes elegido, y en la relación entre rango deedad y franja horaria de los intentos de suicidio. Conclusiones. La caracterización de los intentos de suicidioen nuestra provincia ofrece información relevante, a pesar de sus limitaciones, y ayuda a determinar alguno de los parámetros en los que habrá que sustentar un futuro programa de intervención psicosocial para la prevención de estas conductas ajustado a los perfiles específicos de nuestra población (AU)

Background. Suicides account for a number of deaths that is higher than other traumatic deaths in Spain. Non-fatal suicidal behaviour occurs in a greater proportion than such behaviour with a deadly outcome. There are many causes for this behaviour and it is important to become familiar with them if it is to be prevented. The aim of this article is to describe the characteristics of non-mortal suicidal behaviour in the province of Granada. Method. A retrospective descriptive study of the characteristics of non-mortal suicidal behaviour in Granada during the years 2008 and 2009, according to the data base of the Provincial 061 Service in Granada. The sample includes the demands made to this service in which the literal reason for the alert included the terms: suicide, self-harm or the threat of suicide. The statistical analysis was done with the SPSS 15.0 program. We analyzed the variable non-mortal suicidal behaviour with respect to the independent variables: sex, age, month, day of the week, time slot, health district, resolution of the demand (assigned priority) and fur therattempts. Results. In total we analyzed 535 demands typified as intentional self-injury by un specified means. Statistically significant differences were found when comparing the data for the two years with respect to the month chosen, and in the relationship between age range and time slot of the suicide attempts. Conclusions. Despite its limitations, the characterization of suicidal behaviour in our province offers essential information, and could be useful in designing and developing aprogram of psychosocial intervention for the prevention of suicidal behaviour adjusted to the specific profiles of our population (AU)

Tin ethyl etiopurpurin significantly inhibits vascular smooth muscle cell proliferation in vivo.

Smooth muscle cell proliferation is a major component of restenosis following angioplasty. Hematoporphyrin derivative and other photosensitive compounds inhibit proliferation by causing cellular necrosis upon light activation (photodynamic therapy). Other photosensitive compounds, such as benzoporphyrin derivative, have been suggested as having non-cytotoxic antiproliferative effects without photodynamic therapy, although other studies using benzoporphyrin derivative were negative. Inhibition of smooth muscle cell proliferation was examined in an in vivo rabbit model of vascular injury using a novel synthetic chlorin derivative, tin ethyl etiopurpurin, and benzoporphyrin derivative without photodynamic therapy. Tin ethyl etiopurpurin and benzoporphyrin derivative inhibited smooth muscle cell proliferation by 50-90% of control (p < or = 0.05) without toxic side effects. These results suggest that tin ethyl etiopurpurin and benzoporphyrin derivative without photodynamic therapy may provide a novel and potent antiproliferative therapy that might be useful in the treatment of restenosis.