Characterization of brain tumors by MRS, DWI and Ki-67 labeling index.

With the advent of fast imaging hardware and specialized software, additional non-invasive magnetic resonance characterization of tumors has become available through proton magnetic resonance spectroscopy (MRS), hemodynamic imaging and diffusion-weighted imaging (DWI). Thus, patterns could be discerned to discriminate different types of tumors and even to infer their possible evolution in time. The purpose of this study was to investigate the correlation between MRS, DWI, histopathology and Ki-67 labeling index in a large number of brain tumors. Localized proton spectra were obtained in 47 patients with brain tumors who subsequently underwent surgery (biopsy or tumor removal). We performed MRS with short echo-time (30 ms) and metabolic values in spectra were measured using an external software with 25 peaks. In all patients who had DWI, we measured apparent diffusion coefficients (ADC) in the same region of interest (ROI) where the voxel in MRS was located. In most tumors the histological diagnosis and Ki-67 labeling index had been determined on our original surgical specimen. Cho/Cr, (Lip+Mm)/Cr, NAA/(Cho+Cr) and Glx/Cr indexes in MRS allowed discriminating between low- and high-grade gliomas and metastases (MTs). Likewise, absolute ADC values differentiated low- from high-grade gliomas expressed by Ki-67 labeling index. A novel finding was that high Glx/Cr in vivo MRS index (similar to other known indexes) was a good predictor of tumor grading.

Chagasic granulomatous encephalitis in immunosuppressed patients. Computed tomography and magnetic resonance imaging findings.

American trypanosomiasis (Chagas' disease), a zoonosis caused by Trypanosoma cruzi with a high incidence in Latin America, may induce an uncommon form of localized encephalitis termed "chagoma", found in few immunocompromised patients. The computed tomography (CT) and magnetic resonance imaging (MRI) findings of brain chagoma are reported for 3 males (ages 32, 32 and 9 yr), the first 2 infected with human immunodeficiency virus (HIV) and the third with acute lymphoblastic leukemia. Diagnosis was confirmed by biopsy. CT disclosed a single, supratentorial, nodular-shaped lesion that substantially enhanced with contrast material, localized in parietal or frontal lobes. T1-weighted MRI showed hypointense lesions that enhanced with gadolinium-diethylenetriaminepentaacetic acid, corresponding to extensive hyperintense areas on T2-weighted images, producing mass effect. The imaging pattern of brain chagoma presented here is similar to that of cerebral toxoplasmosis and should be considered in the differential diagnosis of an intracerebral mass lesion in immunocompromised patients.

Meningeal dissemination of retinoblastoma: CT findings in eight patients.

Thirty-seven patients with retinoblastoma were evaluated prospectively by clinical examination, lumbar puncture, and CT. Eight (22%) of the 37 were found to have meningeal dissemination. The tumor was bilateral in three patients. Two cases showed no CT signs of local recurrence. Headache, nausea/vomiting, and restlessness were the most common symptoms. CT scans in these patients showed diffuse meningeal contrast enhancement, nodular masses, ependymal-subependymal enhancement, and ventricular dilatation. Our series of eight patients with meningeal spread illustrates a considerable range of dissemination patterns referable to retinoblastoma. One case illustrated the CT finding of multiple epidural metastases.

Neumocisternotomografia computada en el diagnóstico de los neurinomas del acústico / Computer-assisted neumocisternography in the diagnosis of acoustic tumor

Se estudiaron 390 pacientes portadores de patología expansiva del ángulo pontocerebeloso (neurinomas, meningiomas, metástasis, quistes epidermoides, etc.), efectuándosele una TC con contraste intravenoso (1 ml/Kg peso) con cortes axilares y coronales. Paralelamente hubieron 81 pacientes en los cuales la TC fue normal a pesar de exitir en ellos una fuerte sospecha clínica y electrofisiológica de la presencia de un tumor del nervio acústico. en estos pacientes se llevó a cabo una neumocisternotomografía computada obteniéndose los siguientes resultados: a) 1 caso correspondiente a un repliegue dural sobre la luz del CAI (falso positivo); b) 6 casos de neurinomas del VIII par con localización exclusivamente intracanicular, y c) 3 casos de neurinomas del VIII par que se extendían por fuera del poro acústico (AU)

Neumocisternotomografia computada en el diagnóstico de los neurinomas del acústico / Computer-assisted neumocisternography in the diagnosis of acoustic tumor

Se estudiaron 390 pacientes portadores de patología expansiva del ángulo pontocerebeloso (neurinomas, meningiomas, metástasis, quistes epidermoides, etc.), efectuándosele una TC con contraste intravenoso (1 ml/Kg peso) con cortes axilares y coronales. Paralelamente hubieron 81 pacientes en los cuales la TC fue normal a pesar de exitir en ellos una fuerte sospecha clínica y electrofisiológica de la presencia de un tumor del nervio acústico. en estos pacientes se llevó a cabo una neumocisternotomografía computada obteniéndose los siguientes resultados: a) 1 caso correspondiente a un repliegue dural sobre la luz del CAI (falso positivo); b) 6 casos de neurinomas del VIII par con localización exclusivamente intracanicular, y c) 3 casos de neurinomas del VIII par que se extendían por fuera del poro acústico