[Precocious maturation of the testis associated with excessive secretion of estradiol and testosterone by Leydig cells]. / Przedwczesne dojrzewanie jadra przy nadmiernym wydzielaniu estradiolu i testosteronu przez komórki Leydiga.

We present the quantitative description of spermatogenesis in a 4.5-year-old boy with precocious puberty, where Leydig cell hyperplasia was associated with excessive secretion of testosterone (T), but predominantly with estradiol (E). The results were compared with data obtained from an age-matched group and adult men without hormonal abnormalities. We showed, that excessive secretion of T and E with relative deficiency of FSH is sufficient to induce testicular tubule maturation and qualitatively complete spermatogenesis, although with a poorer quantitative aspect.

Precocious puberty in three boys with Sanfilippo A (mucopolysaccharidosis III A).

Three boys with mucopolysaccharidosis type III A (Sanfilippo) entered puberty at the ages of 5.9, 6.6 and 9.6 years. The diagnosis of central precocious puberty (GnRH-dependent) was established on the basis of pubertal levels of basal and GnRH-stimulated gonadotropins, LH and FSH. All the patients were tall from early infancy, but there was no acceleration of growth velocity or bone maturation despite advanced pubertal stage and high testosterone levels. Computerized tomography of the brain showed changes which are characteristic for Sanfilippo. This is the first time that precocious puberty has been described in Sanfilippo patients. The question of whether the precocious puberty in our Sanfilippo patients is a coincidence or is related in some way remains open.

[Delayed puberty in an 18-year-old female patient with late diagnosis of celiac disease]. / Opóznienie dojrzewania u 18-letniej chorej z pózno rozpoznana celiakia.

A case of a 18-year female patient is presented. The patient suffered from certain symptoms of malabsorption syndrome. She was also retarded sexually. Celiac disease was diagnosed according to ESPGAN criteria. Gluten -free diet produced body weight increase, pain relief, improved well-being and normal menstruation.