Using GPS Data to Study Neighborhood Walkability and Physical Activity.

INTRODUCTION: Urban form characteristics intended to support pedestrian activity, collectively referred to as neighborhood walkability, are thought to increase total physical activity. However, little is known about how neighborhood walkability influences utilization of neighborhood space by residents and their overall physical activity. METHODS: Sociodemographic information and data on mobility and physical activity over 1-week periods measured by GPS loggers and accelerometers were collected from 803 residents of New York City between November 2010 and November 2011. Potentially accessible neighborhood areas were defined as land area within a 1-kilometer distance of the subject's home (radial buffer) and within a 1-kilometer journey on the street network from the home (network buffer). To define actual areas utilized by subjects, a minimum convex polygon was plotted around GPS waypoints falling within 1 kilometer of the home. A neighborhood walkability scale was calculated for each neighborhood area. Data were analyzed in 2014. RESULTS: Total residential neighborhood space utilized by subjects was significantly associated with street intersection density and was significantly negatively associated with residential density and subway stop density within 1 kilometer of the home. Walkability scale scores were significantly higher within utilized as compared with non-utilized neighborhood areas. Neighborhood walkability in the utilized neighborhood area was positively associated with total weekly physical activity (32% [95% CI=17%, 49%] more minutes of moderate-equivalent physical activity across the interquartile range of walkability). CONCLUSION: Neighborhood walkability is associated with neighborhood spaces utilized by residents and total weekly physical activity.

Experimental measurement and mathematical modeling of pulsatile forces on a symmetric, bifurcated endoluminal stent graft model.

The objective of this study was to measure the pulsatile forces acting on a symmetric, bifurcated endoluminal stent graft to validate a computational fluid dynamics (CFD) and analytic model so that they can be used for various graft dimensions. We used a load cell to measure the force owing to the movement of an acrylic model of a bifurcated stent graft under pulsatile flow. This was then simulated with a CFD and analytic model. The main features of the experimental pulsatile force data and the CFD results were consistent. The results showed that the total force was proportional to the inlet pressure cycle. The force rose from 3.32 N at 130 mm Hg systolic to 17.5 N at 250 mm Hg systolic pressure. For the more variable regions of the flow, the experimentally measured forces lagged the computational and analytic results. The CFD and analytic models provide approximate descriptions for the forces acting on a bifurcated stent graft subjected to pulsatile flow. Such models should be of assistance to designers of endoluminal stent grafts.

A laparoscopic endovascular aortobifemoral conduit that can be retained as a long-term bypass: a solution for patients with inadequate iliac access.

PURPOSE: To present a laparoscopic technique for placing a partially stented aortobifemoral (ABF) conduit that can be used for more proximal endovascular manipulations and then be retained as a permanent bypass of occlusive iliac disease. TECHNIQUE: Ethical approval was obtained to use a fresh frozen cadaver. The left common iliac artery, distal aorta, and proximal right common iliac artery were dissected laparoscopically. A curved hollow needle was inserted into the distal aorta, and wire access was obtained. A partially stented bifurcated Dacron bypass graft was deployed under fluoroscopic guidance into the distal aorta. The limbs of the bypass were then used as conduits for endovascular access before being tunneled behind the ureters and anastomosed to the femoral arteries in the usual way, retaining the stented graft as an ABF bypass. CONCLUSION: This novel technique combines laparoscopic access with endovascular manipulation to place an ABF conduit, which can be retained as a permanent bypass without the need for an abdominal incision. This technique could provide a minimally invasive solution for pelvic occlusive disease that hinders endovascular repairs, as well as a minimally invasive means of securing endoluminal access in patients with iliac arteries of inadequate caliber.

Computed tomography virtual intravascular endoscopy in the evaluation of fenestrated stent graft repair of abdominal aortic aneurysms.

BACKGROUND: This study aimed to investigate the diagnostic value of computed tomography virtual intravascular endoscopy (VIE) in the follow-up of patients with abdominal aortic aneurysm (AAA) treated with fenestrated stent grafts. METHODS: A total of 19 patients (17 males and 2 females; mean age: 75 years) with AAA undergoing fenestrated stent grafts were retrospectively studied. Pre- and post-fenestration computed tomography data were reconstructed for the generation of VIE images of aortic ostia and fenestrated stents and compared with two-dimensional axial and multiplanar reformation (MPR) images. Serum creatinine was measured pre and post fenestration to evaluate the renal function. RESULTS: The mean intra-aortic length measured by VIE, two-dimensional axial and MPR were 4.7, 4.4 and 4.6 mm, respectively, for the right renal stent; 5.0, 4.9 and 5.0 mm, respectively, for the left renal stent; and 5.9, 6.0 and 6.0 mm, respectively, for the superior mesenteric artery stent. Comparisons of these measurements did not show significant difference (P > 0.05). The mean diameters of renal artery ostia measured on VIE visualization pre and post fenestration were 9.2 x 8.3 and 10 x 8.9 mm for the right renal ostium; 8.3 x 7.1 and 9.9 x 8.9 mm for the left renal ostium, with significant changes observed (P < 0.01). No renal dysfunction was observed in this group. CONCLUSION: VIE is a valuable visualization tool in the follow-up of fenestrated stent graft repair of AAA by providing intraluminal appearance of fenestrated stents and measuring the length of stent protrusion.

Multislice CT angiography in the follow-up of fenestrated endovascular grafts: effect of slice thickness on 2D and 3D visualization of the fenestration stents.

PURPOSE: To investigate the effect of multislice computed tomography (CT) protocols on the visualization of target vessel stents in patients with abdominal aortic aneurysm (AAA) treated with fenestrated endovascular grafts. METHODS: Twenty-one patients (19 men; mean age 75 years, range 63-86) undergoing fenestrated endovascular repair of AAA were retrospectively studied. Multislice CT angiography was performed with several protocols, and the section thicknesses used in each were compared to identify any relationship between slice thickness and target vessel stents visualized on 2-dimensional (2D) axial, multiplanar reformatted (MPR), and 3-dimensional (3D) virtual intravascular endoscopy (VIE) images. Image quality was assessed based on the degree of artifacts and their effect on the ability to visualize the configuration, intra-aortic location, and intraluminal appearance of the target vessel stents and measure their protrusion into the aortic lumen. RESULTS: There were 7 different multislice CT scanning protocols employed in the 21 patients (25 datasets, with 2 sets of follow-up images in 4 patients). The slice thicknesses and numbers (n) of studies included were 0.5 (n=3), 0.625 (n=6), 1.0 (n=1), 1.25 (n=9), 2.5 (n=3), 3.0 (n=1), and 5.0 mm (n=2). Of these CT protocols, images (especially 2D/3D reconstructions) acquired at 2.5, 3.0, and 5.0 mm were significantly compromised by interference from artifacts. Images acquired with a slice thickness of 1.0 or 1.25 mm were scored equal to or lower than those acquired with a submillimeter section thickness (0.5 or 0.625 mm), with minor degrees of artifacts resulting in acceptable image quality. CONCLUSION: Visualization of the target vessel stents depends on the appropriate selection of multislice CT scanning protocols. Our results showed that studies performed with a slice thickness of 1.0 or 1.25 mm produced similar image quality to those with a thickness of 0.5 or 0.625 mm. Submillimeter slices are not recommended in imaging patients treated with fenestrated stent-grafts, as they did not add additional information to the visualization.

Modeling of antegrade and retrograde flow into a branch artery of the aorta: implications for endovascular stent-grafting and extra-anatomical visceral bypass.

PURPOSE: To compare antegrade and retrograde flow characteristics in a branch of a conduit under typical pulsatile pressure and flows, seeking an answer to the question: "Does it matter whether inflow to a branch vessel is antegrade or retrograde?" METHODS: A model was built to simulate an abdominal aorta with a branch designed to approximate a typical renal artery. Experiments were conducted to measure the flow rates from 40- and 200-mm-long inflow conduit tubes simulating a branch with antegrade and retrograde inflow configurations. For the base case with a flush origin of the branch, the pressure difference between the main conduit and branch vessel was adjusted so that the average branch flow rate was 1.22 L/min, representing average renal artery flow. A pump produced a pulsatile 5-L/min flow of a glycerol/water solution through a tube to mimic blood flow through the aorta at a mean inlet pressure of 97 mmHg, with systolic and diastolic pressures of 121 and 78 mmHg, respectively. Computational fluid dynamics (CFD) simulations were performed for the flush, antegrade inflow, and retrograde inflow cases. The CFD-predicted flow rates at the branch vessel outlet for all 3 geometries were compared with the experiments. RESULTS: From the experiments, the mean time-average branch vessel outflow rate through a 40-mm conduit for the antegrade case was 1.22+/-0.01 L/min, which was the same as the retrograde case (1.21+/-0.01 L/min; within the experimental error). However, the branch vessel outflow flow rate through a 200-mm conduit for the retrograde case was 0.07 L/min lower than the antegrade. The results from the CFD model were in good agreement with the experiments. CONCLUSION: The experiments and CFD results suggest that there is negligible difference in the outflow rates to a branch vessel in antegrade and retrograde directions for 40-mm-long conduits. However, for a 200-mm conduit, the flow to a branch vessel through the retrograde path is lower than for the antegrade direction, which has implications for the insertion of branches to stent-grafts and extra-anatomical surgical bypass for visceral revascularization.

CT virtual intravascular endoscopy in the visualization of fenestrated stent-grafts.

PURPOSE: To report the diagnostic value of computed tomographic (CT) virtual intravascular endoscopy (VIE) in the assessment of patients with abdominal aortic aneurysm (AAA) treated with fenestrated endovascular grafts. METHODS: Eight patients (7 men; mean age 76 years, range 70-82) with AAAs unsuitable for open surgery or conventional endovascular repair had fenestrated endovascular grafts implanted. Both pre- and post-fenestration multislice CT data were used to generate VIE images of the visceral artery ostia and the side branch fenestrated stents. CT VIE images were compared with conventional 2-dimensional (2D) axial CT and multiplanar reformatted (MPR) images for the ability to visualize the intraluminal appearance of stents, as well as to measure the length of stents that protruded into the aortic lumen. RESULTS: Various fenestrations were deployed in 27 aortic branches. Scalloped and large fenestrations were implanted in 6 side branch ostia, respectively, and small fenestrations in 15 renal artery ostia. Fewer than half of the stents (37%) were found to be circular on VIE images, while the remaining stents were flared to varying extents at the inferior portion. The majority (96%) of stents protruded into the lumen up to 7.0 mm. Although the configuration of the side branch ostia changed to a variable extent, no significant difference was apparent between the diameters of branch ostia before and after fenestration (p>0.05). CONCLUSION: Our preliminary study shows that VIE proved superior to conventional 2D or MPR images in visualizing the final configuration of the fenestrated vessels and was comparable to the other techniques in measuring stent protrusion into the aortic lumen. VIE could be a valuable technique to identify any suspected abnormalities associated with fenestrated endovascular grafts by demonstrating the final intraluminal configuration of the stents in the fenestrated vessels.

Large iliac arteries: a high-risk group for endovascular aortic aneurysm repair.

PURPOSE: To examine if the presence of large iliac arteries is a potential risk factor for the development of a type Ib endoleak (iliac sealing zone) or need for iliac artery-related secondary intervention in patients undergoing endovascular abdominal aortic aneurysm repair. METHODS: The medical notes and all preoperative and postoperative plain abdominal radiographs and computer tomographic scans were reviewed for a consecutive series of 100 patients (89 men; mean age 75 years, range 56-91) with large iliac arteries (mean 19.7 mm, range 16-22) who had Zenith endovascular stent-grafts inserted for management of aortoiliac aneurysmal disease from January 1999 until September 2002. Endpoints were all-cause mortality, aneurysm-related death, endoleak, secondary intervention, secondary interventions, and stent-graft migration. RESULTS: Mean follow-up was 30.1+/-8.3 months; at the last follow-up, 30% of patients were dead, 3% were aneurysm-related. Seven (7%) patients developed a type Ib endoleak, with the remainder being type II (29%), type Ia (2%), type III (1%), and type V (endotension, 1%). Eight (27.5%) type II endoleaks persisted, with the remainder closing spontaneously with sac shrinkage. The iliac artery-related secondary intervention rate was 10%, and the overall secondary intervention rate was 16%. CONCLUSION: Iliac arteries between 16 and 22 mm in diameter may be treated with a cuff to the iliac limb with an expectation of 90% efficacy. Surveillance is required, with a high index of suspicion for type 1b endoleaks. Early secondary iliac intervention with extension to the external iliac artery is recommended if there is an increase in sac size after 6 months.

Treatment of infrarenal abdominal aortic aneurysms with oversized (36-mm) Zenith endografts.

PURPOSE: To evaluate the outcome of treating infrarenal abdominal aortic aneurysms with unfavorable necks using the 36-mm Zenith endograft. METHODS: The indication for use of the 36-mm endograft for infrarenal aortic aneurysm was a minimum 20-mm-long sealing zone and a diameter >28 mm at any point but <34 mm, varying more than 3 mm in contour. A series of 67 patients (64 men; mean age 76.2 years, range 59.5 to 88.3) who had been treated with the 36-mm endografts between June 1999 and February 2004 were assessed for medium-term outcomes. The patients were identified from the device planning records. Follow-up was carried out using chart review and direct patient contact. The indication for use of the endograft was checked with the aneurysm neck profile from the original planning diagrams. Cause of death was ascertained from the treating clinician, the medical record, or the State Death Registry. Outcome endpoints were proximal type I and type III endoleaks, migration, sac size change, and death. RESULTS: The mean diameter of the sealing zone was 31.9+/-1.6 mm within the 20-mm segment from the lowest renal artery. Stent-graft delivery was achieved in all 67 patients. Two (3%) patients died within 30 days from non-graft-related cardiorespiratory causes. Proximal type I endoleaks were identified in 3 (4.5%) patients: 2 during deployment and another at 9 days. The mean follow-up period for the 65 patients who survived 30 days was 26.9+/-12.6 months (range 2-66). Migration occurred in 1 patient with development of a type III endoleak and sac reperfusion due to separation of the graft body from the bare anchor stent owing to suture breakage. Forty-seven patients were alive at the last review. The aneurysm sac had contracted or was unchanged in 45 (96%) cases. Minor enlargements of the sac were observed in 2 patients. The re-intervention rate was 16.4% (11 patients). There was 1 conversion to open repair to treat perigraft sepsis. The aneurysm- and procedure-related mortality was 4.5%; no patient experienced rupture. All-cause mortality was 29.9% (20/67). CONCLUSION: Large caliber endografts such as the Zenith 36-mm are an alternative option to open surgery or fenestrated endografting for some infrarenal aneurysms.

Short to midterm outcomes of fenestrated endovascular grafts in the treatment of abdominal aortic aneurysms: a systematic review.

PURPOSE: To perform a systematic review of the short to midterm outcomes of fenestrated endovascular grafts in patients with abdominal aortic aneurysms (AAA). METHODS: A search of PubMed and Medline databases for English-language literature was performed to find studies published between 1999 and 2006. Studies investigating the short to midterm results of fenestrated endovascular grafts for AAA were analyzed for clinical outcomes and postprocedural complications. RESULTS: Nineteen studies involving fenestrated endovascular grafting were retrieved, and 6 of them met criteria for inclusion in the analysis. The remaining studies were excluded because they dealt with technical or case reports or cumulative addition of previous cases. Pooled estimates (95% confidence interval) of postprocedural complications were 1.1% (0.4%-2.7%) for 30-day mortality; 8.3% (2.9%-13.6%) for late mortality; 97% (92%-100%) and 90% (85%-95%) for perfusion of fenestrated vessels at perioperative and late follow-up, respectively; 13.3% (4.1%-22.5%) for postprocedural renal dysfunction; and 11.2% (3.2%-22.5%) and 9.4% (2.6%-16.3%) for early and late endoleak, respectively. There was correlation between preoperative renal insufficiency and postprocedural renal dysfunction, although this was not a statistically significant difference (p=0.2). CONCLUSION: Our systematic review showed that fenestrated endovascular grafting provides an alternative technique to treat patients with complex aneurysm necks, achieving lower mortality than open repair under comparable conditions. Preoperative renal impairment is a strong indicator of postoperative renal dysfunction. Long-term stability and patency of the fenestrated vessels deserves to be validated.

Outcomes of fenestrated endografts in the treatment of abdominal aortic aneurysm in Western Australia (1997-2004).

PURPOSE: To describe a 7-year experience with abdominal aortic aneurysm (AAA) repair using fenestrated Zenith endovascular endografts. METHODS: Six endovascular surgeons from 7 medical centers in Perth, Western Australia, contributed data to this retrospective study of 58 AAA patients (51 men; mean age 75.5+/-8.5 years, range 60-94) treated with fenestrated endografts. Fenestrations were applied to 116 target vessels; more than half of patients had >/=2 target vessels. The results were based on satisfactory deployment of the stent-graft and fenestrations (technical success), technical success and no complications (procedural success), and aneurysm exclusion with no endoleak, rupture, unresolved complications, or dialysis (treatment success). RESULTS: Technical success was 82.8% for patients (90.5% for target vessels), procedural success was 74.1%, and treatment success was 94.8%. There were no cases of conversion or rupture. The 30-day mortality rate was 3.4% (n=2). Over a mean follow-up of 1.4+/-1.2 years, 10 (17.2%) patients experienced loss of a target vessel (9.5% of target vessels). Factors associated with target vessel loss were no stent, >60 degrees neck angulation, multiple renal vessels, and vessel diameter

A laparoscopic access technique for endovascular procedures: surgeon training in an animal model.

PURPOSE: To present a laparoscopic technique for placing a transperitoneal conduit in the common iliac artery (CIA) or distal aorta to circumvent stenosed or occluded iliac systems and to assess the success of this laparoscopic access in a live animal model. TECHNIQUE: A porcine model was used owing to similarities in anatomy and size of the pig aorta to the human common iliac artery (CIA). Ethical approval was obtained, and the technique was developed in 8 animals under general anesthesia. A curved hollow needle, a partially stented Dacron conduit, an airtight laparoscopic port and a sealing sheath and valve were developed specifically for percutaneous access through the abdominal wall. A transperitoneal approach was used to the distal aorta. Cannulation by the curved hollow needle via the new port was under direct vision. The conduit was inserted over a guidewire after needle removal and deployed under fluoroscopy. The distal end of the conduit was secured by the sealing sheath and valve, enabling wire and catheter exchange thereafter. A 2-day educational workshop was held for 12 vascular surgeons with a range of laparoscopic experience. After learning the technique on a simulator model, they worked in pairs, alternating surgeon/assistant roles to insert conduits into 12 animals under general anesthesia. Laparoscopic cannulation in all 12 animals was successful. There was no bleeding around the conduit at the aortic arteriotomy. All animals were euthanized after confirmation of conduit patency by back-bleeding. CONCLUSION: This novel technique bridges the gap between laparoscopic and endovascular techniques in striving for minimally invasive solutions to the treatment of vascular disease. Adaptation to human beings is currently underway and will mean increasing the applicability of endovascular solutions to those patients in whom it would otherwise be denied. The technique would appear not to require specialist laparoscopic skills.

Movement and dislocation of modular stent-grafts due to pulsatile flow and the pressure difference between the stent-graft and the aneurysm sac.

PURPOSE: To investigate the stability and movement of modular aortic stent-grafts subjected to oscillating forces from pulsatile blood flow, with particular reference to the thoracic aorta. METHODS: Analytical mathematical modeling was used to understand the forces on modular grafts. In a benchtop experiment, a transparent acrylic box was filled with water to mimic an aneurysm. Two stent-grafts were placed inside the box in a nested, arched configuration where one component was partly inside the other. A pump produced a pulsatile approximately 5-L/min flow of water through the stent-grafts at a mean inlet pressure of approximately 100 mmHg (approximately 13,330 Pa), with systolic and diastolic pressures of approximately 130 and approximately 80 mmHg, respectively (pulse pressure 50 mmHg). The movement of the 2 modular stent-grafts was observed. RESULTS: The curved stent-graft system oscillated transversely when there was zero mean pressure difference between the stent-graft and the aneurysm. As the mean pressure difference was increased, this transverse graft movement was damped and then disappeared. A relatively large pressure difference caused the stent-graft to inflate and become sturdier. In terms of stability, the analytical mathematical model for a 30-mm-diameter Zenith modular stent-graft curved through 90 degrees (with the ends of the graft fixed in place) showed that the modular components will separate at a pressure difference of 0 mmHg for 1 stent segment overlap (20 mm) and at an average 59 mmHg pressure difference for 2 stent overlaps, but the device would not separate at a pressure difference of 90 mmHg for 3 stent overlaps. CONCLUSION: Transverse cyclic movement of the curved stent-graft system with pulsation indicates a pressurized sac. When the pressure difference is large and there is a blood-tight seal between the aneurysm and the stent-graft, then the transverse movement of the stent-graft is minimal, but the risk for modular separation is highest. Curved thoracic endografts are subject to forces that may cause migration or separation, the latter being more likely if the seal between the graft and the sac is blood tight, if the blood pressure is high, and if the diameter of the graft is small and the sac large. Operators should plan for maximum overlap of modular components when treating large or long thoracic aneurysms.

Infected endoluminal stent-graft: implications for endotension, late endoleaks, and prophylactic antibiotics.

PURPOSE: To retrospectively review a case of stent-graft infection that presented as continued aneurysm expansion after endoluminal repair. CASE REPORT: A 75-year-old man with an asymptomatic 6.1-cm abdominal aortic aneurysm (AAA) was treated with a Talent stent-graft, which was complicated by postimplantation syndrome. At 1 year, a secondary intervention was performed for migration with type I endoleak. Despite the absence of a demonstrable endoleak thereafter, the AAA continued to expand until it was 9 cm in diameter and symptomatic. At this stage, 6 months after the secondary procedure, the graft was explanted and an axillobifemoral graft inserted. Propionibacterium acnes was cultured from all specimens of thrombus, aortic wall, and graft. The patient recovered and was asymptomatic until his death from myocardial infarction 6 months after discharge. CONCLUSIONS: Stent-graft infection may be a cause of unexplained endotension. Special culture techniques may be required to identify the infecting organism. Prophylactic antibiotics against skin organisms should be considered for all implantations and arterial diagnostic and therapeutic procedures traversing a stent-graft.

Experimental force measurements on a bifurcated endoluminal stent graft model: comparison with theory.

The goal of this study was to experimentally validate a steady-state mathematical model, which can be used to compute the forces acting on a bifurcated endoluminal stent graft. To accomplish this task, an acrylic model of a bifurcated graft was used for the force measurements. The graft model was connected to the inlet piping with a flexible rubber membrane that allowed the graft model to move. This allowed us to measure the force owing to the movement of the graft model with a calibrated load cell. Steady-state blood flow was assumed, and the working fluid was water. The experimental data were found to be consistent with the results from a previously published mathematical model: the graft force is strongly dependent on the proximal or inlet pressure and the inlet area. The force tends to be weakly dependent on flow rate. More research work will be required to determine whether the steady-state force model examined in this article provides a realistic determination of the forces on an endoluminal stent graft that is subject to pulsatile blood flow.

In situ stent-graft fenestration to preserve the left subclavian artery.

PURPOSE: To report our first clinical application of a new technique for in situ fenestration of a thoracic stent-graft. CASE REPORT: After completing a series of in vitro and in vivo experiments, in situ stent-graft fenestration was employed during endograft repair of a saccular thoracic aortic aneurysm in a 77-year-old woman. Because the stent-graft would have covered the left subclavian artery ostium, a modified Zenith TX1 thoracic stent-graft was deployed then fenestrated transluminally using a guidewire followed by serial cutting balloons, which created a fenestration over the LSA sufficiently large to accommodate a Jomed covered stent on an 8-mm balloon. Completion angiography showed exclusion of the aneurysm and brisk flow into the LSA. Following the procedure, the arm pressures were nearly equal. The 6-month CT scan showed no endoleak and a patent subclavian artery stent. CONCLUSIONS: In situ graft fenestration to preserve the left subclavian artery after deliberate coverage during endovascular repair of a thoracic aortic aneurysm appears feasible in this initial clinical application. There are uncertainties regarding the long-term stability of the fabric tears that are an inherent part of this technique.

Effects of insulin-sensitising agents in mice with hepatic insulin resistance.

AIMS/HYPOTHESIS: The metabolic abnormalities of insulin resistance are ameliorated by insulin sensitisers via different mechanisms. Metformin decreases hepatic glucose output, whereas rosiglitazone (RSG) is an agonist for peroxisome proliferator activated receptor (PPAR)gamma, highly expressed in fat. To gain insight into the mechanisms of action of these drugs, we compared their actions in two models of insulin resistance: the obese, hyperglycaemic ob/ob mouse and the liver specific insulin receptor knockout (LIRKO) mouse. METHODS: Control, ob/ob, and LIRKO mice were divided into three groups that received metformin (300 mg/kg body weight/day), RSG (3 mg/kg body weight/day), or placebo for 3 weeks. RESULTS: In the presence of the severe hepatic insulin resistance of the LIRKO mouse, neither metformin nor RSG had any significant effect on glucose or insulin tolerance tests. On the other hand, RSG decreased serum concentrations of total cholesterol, LDL, and HDL in LIRKO mice. Adipocyte PPARgamma gene and protein expression, and adipocyte size were all increased in LIRKO mice treated with RSG, whereas fat-cell size in control animals was decreased by RSG. CONCLUSION/INTERPRETATION: TZDs probably improve some lipid parameters of the dysmetabolic syndrome associated with diabetes mellitus even in the presence of absolute hepatic insulin resistance, but both metformin and TZDs require an operating insulin signalling system in the liver for their effects in glucose homeostasis.

Retrograde fenestration of endoluminal grafts from target vessels: feasibility, technique, and potential usage.

PURPOSE: To report initial experiments involving a new method for percutaneous intraprocedural stent-graft fenestration from the target vessel. TECHNIQUE: In bench and canine models, the fabric of an implanted Zenith endograft was punctured easily using the stiff end of a coronary 0.014-inch guidewire delivered through the target vessel (e.g., renal or iliac artery). A 20-G cutting needle was passed over the coronary wire to enlarge the puncture site, followed by a cutting balloon to create a fenestration that was of sufficient size to allow deployment of a stent. CONCLUSIONS: In vivo endograft fenestration of a Zenith endograft is feasible. In addition to providing a percutaneous means of intentionally fenestrating a stent-graft from the artery to be perfused, the technique has potential application as a bailout maneuver after inadvertent side branch occlusion. Although the time to achieve successful fenestration in the experimental model was long, refinement may achieve performance times adequate to maintain viability of the end organ.

Plain radiographic surveillance of abdominal aortic stent-grafts: the Liverpool/Perth protocol.

PURPOSE: To present a protocol for plain radiographic surveillance of abdominal aortic stent-grafts that addresses the main variables in need of standardization: (1) patient position, (2) radiographic centering point, and (3) focus-to-film distance. TECHNIQUE: Our policy is to perform baseline anteroposterior and lateral films following endoluminal grafting and repeat the studies annually. These are the most important films to assess migration and component separation; supplementary right and left posterior oblique radiographs may help identify wireform fractures. It is best to perform radiography before computed tomography if both tests are scheduled for the same day, as excretion of intravenous contrast opacifies the renal collecting systems and interferes with radiographic analysis. CONCLUSIONS: Evaluation of the radiographs depends on the design of the stent-graft, so it is important to understand graft construction and the position of the radiopaque markers to best assess changes on follow-up films.

Follow-up after endovascular aortic aneurysm repair: the plain radiograph has an essential role in surveillance.

Periodic follow-up is mandatory for patients with aortic stent-grafts. Central to surveillance is the establishment of a baseline against which changes can be detected. Computed tomography (CT) has been the benchmark of follow-up imaging for endografts, but comparison of serial AP and lateral plain radiographs will detect structural alterations that can be missed on CT scans. In this review, we illustrate these common endograft complications and the value of plain radiographs in their detection. We believe that the plain radiograph should be the cornerstone of aortic endograft surveillance. However, a standardized protocol should be used to avoid parallax and positioning errors that affect interpretation.