Asunto(s)
Dermatitis Exfoliativa/genética , Dermatitis Exfoliativa/patología , Hiperhidrosis/genética , Hiperhidrosis/patología , Mutación , Trastornos de la Pigmentación/genética , Trastornos de la Pigmentación/patología , Hermanos , Transglutaminasas/genética , Administración Cutánea , Biomarcadores/metabolismo , Niño , Preescolar , Dermatitis Exfoliativa/tratamiento farmacológico , Educación Médica Continua , Emolientes/administración & dosificación , Emolientes/uso terapéutico , Femenino , Pie , Mano , Humanos , Hiperhidrosis/tratamiento farmacológico , Masculino , Trastornos de la Pigmentación/tratamiento farmacológico , Enfermedades de la Piel/congénitoRESUMEN
Sporotrichoid tuberculosis is a rare form of cutaneous tuberculosis; it primarily affects children after a post-traumatic inoculation. The diagnosis is often difficult and based on a set of arguments; it should be considered in any sporotrichoid lesion, especially in tuberculosis endemic countries. The following describes a new case of Mycobacterium tuberculosis skin infection with an unusual sporotrichoid clinical appearance in a healthy woman, emphasizing the diagnostic difficulties with a review of literature.
Asunto(s)
Carcinoma de Células Escamosas/diagnóstico , Dermoscopía , Neoplasias Faciales/diagnóstico , Neoplasias Cutáneas/diagnóstico , Enfermedades de los Trabajadores Agrícolas/diagnóstico , Enfermedades de los Trabajadores Agrícolas/patología , Biomarcadores de Tumor , Carcinoma de Células Escamosas/química , Carcinoma de Células Escamosas/patología , Diagnóstico Diferencial , Neoplasias Faciales/química , Neoplasias Faciales/patología , Humanos , Queratina-5/análisis , Queratina-6/análisis , Queratinocitos/patología , Queratosis Seborreica/diagnóstico , Masculino , Melaninas/análisis , Melanoma/diagnóstico , Persona de Mediana Edad , Neoplasias Inducidas por Radiación/química , Neoplasias Inducidas por Radiación/diagnóstico , Neoplasias Inducidas por Radiación/patología , Fagocitosis , Neoplasias Cutáneas/química , Neoplasias Cutáneas/patología , Luz SolarRESUMEN
Erythromelalgia is a rare disease whose etiology is poorly understood. It is characterized by paroxysmal attacks of erythema, pain, and warmth of the extremities and can be primary or secondary. We report a case of primary familial erythromelalgia and stress the difficulties in its therapeutic management. We provide a brief update on the pathophysiology and treatment of primary erythromelalgia.
Asunto(s)
Eritromelalgia/terapia , Adolescente , Eritromelalgia/complicaciones , Femenino , Humanos , Queratodermia Palmoplantar/complicacionesAsunto(s)
Cistoadenoma/congénito , Neoplasias de las Glándulas Sudoríparas/congénito , Adulto , Biopsia , Cistoadenoma/diagnóstico , Cistoadenoma/patología , Cistoadenoma/cirugía , Progresión de la Enfermedad , Femenino , Humanos , Piel/patología , Esternón , Neoplasias de las Glándulas Sudoríparas/diagnóstico , Neoplasias de las Glándulas Sudoríparas/patología , Neoplasias de las Glándulas Sudoríparas/cirugía , Glándulas Sudoríparas/patologíaAsunto(s)
Neoplasias Primarias Múltiples/diagnóstico , Neoplasias de las Glándulas Sudoríparas/diagnóstico , Siringoma/diagnóstico , Diagnóstico Diferencial , Humanos , Masculino , Persona de Mediana Edad , Neoplasias Primarias Múltiples/patología , Neoplasias Primarias Múltiples/terapia , Piel/patología , Neoplasias de las Glándulas Sudoríparas/patología , Neoplasias de las Glándulas Sudoríparas/terapia , Glándulas Sudoríparas/patología , Siringoma/patología , Siringoma/terapiaAsunto(s)
Antimetabolitos Antineoplásicos/efectos adversos , Neoplasias del Colon/tratamiento farmacológico , Desoxicitidina/análogos & derivados , Fluorouracilo/análogos & derivados , Síndrome Mano-Pie/diagnóstico , Hiperpigmentación/inducido químicamente , Antimetabolitos Antineoplásicos/uso terapéutico , Capecitabina , Desoxicitidina/efectos adversos , Desoxicitidina/uso terapéutico , Fluorouracilo/efectos adversos , Fluorouracilo/uso terapéutico , Estudios de Seguimiento , Humanos , Hiperpigmentación/diagnóstico , Masculino , Remisión EspontáneaRESUMEN
BACKGROUND: Tripe palms is a rare cutaneous paraneoplastic syndrome, primarily evocative of lung and gastric neoplasia. Association of many paraneoplastic diseases has also been reported. PATIENTS AND METHODS: A 49-year-old man with a history of alcoholism and smoking addiction reported haemoptysis and thoracic pains present for one year. The physical examination showed left lung condensation. The skin examination revealed a thickened yellowish keratoderma with exaggerated skin ridges and digital clubbing. A diagnosis of paraneoplastic tripe palms was made, prompting repetition of the biopsy which ultimately revealed a neuroendocrine carcinoma. Skeletal scintigraphy showed periosteal proliferation with hypertrophic osteoarthropathy. COMMENTS: "Tripe palms" or "osteoarthritic acanthosis" is a paraneoplastic syndrome. It involves an acquired keratoderma taking on a yellow velvety appearance with accentuation of dermatoglyphic lines. Malignancy is discovered in over 90% of individuals with tripe palms. If malignancy is isolated, it mostly involves the lung (53%). Gastric cancer is associated in 77% of cases if the condition is associated with acanthosis nigricans. In approximately one third of cases, the keratoderma may resolve, generally after treatment of the tumour. The association of many paraneoplastic syndromes has also been reported, in particular digital clubbing and hypertrophic osteoarthropathy. At least 90% of cases of hypertrophic osteoarthropathy in adults occur in patients who have or will eventually develop a malignancy. It is characterized by periostosis of long bones, joint pain, and clubbing, and it is often seen on bone scintigraphy during staging of lung carcinoma.
Asunto(s)
Carcinoma de Células Grandes/diagnóstico , Carcinoma Neuroendocrino/diagnóstico , Queratosis/etiología , Neoplasias Pulmonares/diagnóstico , Osteoartropatía Hipertrófica Secundaria/etiología , Síndromes Paraneoplásicos/etiología , Biomarcadores de Tumor/análisis , Carcinoma de Células Grandes/complicaciones , Carcinoma Neuroendocrino/complicaciones , Cromogranina A/análisis , Dermatoglifia , Humanos , Queratosis/patología , Neoplasias Pulmonares/complicaciones , Neoplasias Pulmonares/diagnóstico por imagen , Neoplasias Pulmonares/metabolismo , Metástasis Linfática , Masculino , Fumar Marihuana/efectos adversos , Persona de Mediana Edad , Proteínas de Neoplasias/análisis , Proteínas de Neoplasias/metabolismo , Cuidados Paliativos , Síndromes Paraneoplásicos/patología , Cintigrafía , Fumar/efectos adversos , Sinaptofisina , Tibia/diagnóstico por imagen , Tomografía Computarizada por Rayos X , Proteínas de Transporte Vesicular/análisisAsunto(s)
Síndrome de Sweet/etiología , Tuberculosis Ganglionar/diagnóstico , Antituberculosos/uso terapéutico , Femenino , Humanos , Isoniazida/uso terapéutico , Persona de Mediana Edad , Pirazinamida/uso terapéutico , Rifampin/uso terapéutico , Tuberculosis Ganglionar/complicaciones , Tuberculosis Ganglionar/tratamiento farmacológicoAsunto(s)
Antibacterianos/efectos adversos , Ciprofloxacina/efectos adversos , Erupciones por Medicamentos/etiología , Síndrome de Sweet/inducido químicamente , Dacriocistitis/tratamiento farmacológico , Dermatosis Facial/inducido químicamente , Femenino , Dermatosis del Pie/inducido químicamente , Dermatosis de la Mano/inducido químicamente , Humanos , Persona de Mediana EdadRESUMEN
A prospective study of syphilis cases over a period of 2 years (January 2008 to September 2009) was carried out in the Department of Dermatology of the Hassan II University Hospital Center in Fes, Morocco. A total of 57 cases were identified. The M/F sex ratio was 0.89. Mean patient age was 40.5 years (range, 22-80). Risk factors included unprotected sex in 96.5% of cases and multiple partners in 42.1%. Nine patients had a history of sexually transmitted infection. No patient had received blood transfusion. Clinical picture was late latent syphilis in 70.2% of cases (n = 41). Only one case was associated with human immunodeficiency virus. The mainstay treatment was intramuscular benzathine benzylpenicillin. Outcome was favorable in 48 cases.
Asunto(s)
Sífilis/epidemiología , Adulto , Distribución por Edad , Anciano , Anciano de 80 o más Años , Antibacterianos/uso terapéutico , Femenino , Humanos , Masculino , Persona de Mediana Edad , Marruecos/epidemiología , Penicilina G Benzatina/uso terapéutico , Estudios Prospectivos , Factores de Riesgo , Distribución por Sexo , Parejas Sexuales , Sífilis/diagnóstico , Sífilis/tratamiento farmacológico , Sexo InseguroRESUMEN
Tuberculosis is still endemic in Morocco. Cutaneous tuberculosis is the fifth most common form after pleuropulmonary, glandular, digestive and urogenital tract tuberculosis. The purpose of this single-center prospective study is to describe all cases of cutaneous tuberculosis treated between May 2006 and June 2009. Diagnosis was suspected based on clinical, immunological and histological features. The main clinical presentations, i.e., scrofuloderma and gumma, were consistent with endemicity of tuberculosis in Morocco. Since definitive diagnosis by detection of the tubercle bacillus was rarely possible, therapy was usually undertaken presumptively based on clinical and laboratory findings and therapeutic response.