RESUMEN
The structure of the crown ether 1,8-(3,6,9-trioxaundecane-1,11-diyldioxy)-9,10-dihydro-10,10-dimethylanthracene-9-ol, C(24)H(30)O(6).H(2)O (1), code name P326, the parent compound for a series of derivatives, has been determined by both X-ray diffraction at room temperature and neutron diffraction at very low temperature. The unit cells are very similar at both temperatures and in both cases the crystals exhibit P2(1) symmetry with Z = 4 (two molecules, A and B, respectively, per asymmetric unit) and pseudosymmetry P2(1)/c. The higher symmetry is broken mainly by the two independent water molecules in the unit cell, some reflections which would be absent in P2(1)/c having strong intensities in both the X-ray and neutron data. In both molecules A and B hydrogen bonds involving the water molecule stabilize the macrocyclic ring structure, one involving the macrocyclic O(9) as a donor. Close contacts between the water and macrocyclic O atoms in each molecule also suggest the presence of two bifurcated hydrogen bonds, involving water HW2 to both O(16) and O(18), and water HW1 to both O(18) and O(20), respectively, with considerable variation in the geometry being present. Both molecules A and B exhibit very close pseudosymmetry across a plane perpendicular to the molecular plane and through atoms C(9) and O(18), and in addition are predominantly planar structures. The X-ray analysis failed to reveal one H atom per water molecule, each being subsequently included after location and refinement in the neutron analysis.
RESUMEN
Knee ligamentous injuries persist in the sport of Alpine skiing. To better understand the load mechanisms which lead to injury, pure varus/valgus and pure axial moments were applied both singly and in combination to the right knees of six human test subjects. The corresponding relative knee rotations in three degrees of freedom were measured. Knee flexion angles for each test subject were 15 and 60 degrees for the individual moments and 60 degrees for the combination moments. For both knee flexion angles the hip flexion angle was 0 degrees. Leg muscles were quiescent and axial force was minimal during all tests. Tables of data include sample statistics for each of four flexibility parameters in each loading direction. Data were analyzed statistically to test for significant differences in flexibility parameters between the test conditions. In flexing the knee from 15 to 60 degrees, the resulting knee rotations under single moments depended upon flexion angle with varus, valgus, and internal rotations increasing significantly. Also, rotations were different depending on load direction; varus rotation was significantly different and greater than valgus rotation at both flexion angles. Also external rotation was significantly different and greater than internal at 15 degrees flexion, but not at 60 degrees flexion. Coupled rotations under single moments were also observed. Applying pure varus/valgus moments resulted in coupled external/internal rotations which were inconsistent and hence not significant. Applying pure axial moments resulted in consistent and hence significant varus/valgus rotations; an external axial moment induced varus rotation and an internal axial moment induced valgus rotation. For combination moments, varus/valgus rotations decreased significantly from those rotations at similar load levels in the single moment studies. Also, a varus moment significantly increased external rotation and a valgus moment significantly decreased internal rotation. These differences indicate significant interaction between corresponding load combinations. These results suggest that load interaction is a potentially important phenomenon in knee injury mechanics.
Asunto(s)
Articulación de la Rodilla/fisiología , Ligamentos Articulares/fisiología , Adulto , Fenómenos Biomecánicos , Ingeniería Biomédica/instrumentación , Diseño de Equipo , Humanos , Masculino , Movimiento , Contracción Muscular/fisiología , Músculos/fisiología , Rango del Movimiento Articular/fisiología , RotaciónRESUMEN
The contributions of this paper are twofold. One is the design and performance evaluation of new equipment to determine the rotational flexibility of the human knee in vivo. Since determining knee flexibility requires the application of external loads and the measurement of knee rotations, the new equipment consists of a load application stand and a triaxial goniometer. The triaxial goniometer noninvasively mounts to the leg and directly measures the relative three degrees-of-freedom rotations of the knee sequentially and independently. The goniometer incorporates several unique design features which enhance measurement accuracy. The load stand applies pure varus/valgus and external/internal axial moments either individually or in combination through the use of motors controlled by the test subject. Unique to this design are features which enable the application of moments to the knee which minimise shear forces. Other unique design features permit the stand to control hip and knee flexion angles, muscle contraction, and axial loading. To assess the accuracy with which rotations are measured during experiments, three tests were conducted with the equipment. One test evaluated the inherent accuracy of the goniometer, a second test assessed the potential for goniometer slippage during loading, and a third explored the effect of goniometer mounting on the repeatability of results. A special verification apparatus facilitated evaluation of goniometer inherent accuracy. A second contribution of the paper is an investigation of the effect of foot constraints (i.e. boundary conditions) on flexibility results. To make this investigation, three subjects were tested with the knee at 15 degrees of flexion. Results revealed large differences in flexibility between constraining the foot in both external/internal and varus/valgus rotations and permitting the foot to rotate freely in the direction not being loaded. Further, constraint moments as high as 23 Nm were also recorded. These results emphasise that in order to obtain accurate flexibility results for isolated loads, the foot must be unconstrained by the loading apparatus.