RESUMEN
To determine the half-life and vitreous clearance of trifluorothymidine, a drug that demonstrates good toxicity against cytomegalovirus (CMV), we injected 200 micrograms of the drug intravitreally in the eyes of nine New Zealand white rabbits. None of the rabbits showed any adverse reactions to the injection or the drug. The rabbits were killed at 3, 6, 12, 24 or 72 hours. High-performance liquid chromatography was used to measure the vitreous trifluorothymidine concentration. The half-life of the drug was found to be 3.15 hours, and the vitreous concentration remained above the ID50 (concentration required to inhibit cytopathic effects by 50% compared with control cultures) for CMV for about 30 hours. We conclude that trifluorothymidine may be of future benefit in the management of CMV retinitis.
Asunto(s)
Trifluridina/farmacocinética , Cuerpo Vítreo/metabolismo , Animales , Cromatografía Líquida de Alta Presión , Tolerancia a Medicamentos , Semivida , Inyecciones , ConejosRESUMEN
In two patients secondary cataracts developed after pars plana vitrectomy. In both cases the lens was removed from the pars plana, and the anterior capsule was kept intact. In one patient a posterior chamber lens was placed in the ciliary sulcus 3 months after the lens had been removed, and in the other patient a posterior chamber lens was implanted intraoperatively after pars plana lensectomy and vitrectomy. Improved visual results were obtained in both cases, and there was no evidence of rubeosis or elevated intraocular pressure. In selected cases preservation of the anterior capsule may be important to implant posterior chamber lenses in eyes requiring pars plana lensectomy and vitrectomy. To our knowledge this technique has not previously been reported.
Asunto(s)
Catarata/etiología , Retinopatía Diabética/complicaciones , Lentes Intraoculares , Vitrectomía/efectos adversos , Anciano , Extracción de Catarata , Humanos , Terapia por Láser , Masculino , Agudeza VisualRESUMEN
Explosions of car batteries have become a frequent cause of eye injuries. A total of 62 patients were seen in our clinic during eight consecutive months. A wide range of injuries were discovered that extended from the anterior segment to the retina. The most common injuries were acid-induced conjunctivitis, corneal abrasions, and iridocyclitis. Hospitalization and surgery were required in some cases.