1.
J Enzyme Inhib Med Chem
; 26(2): 295-300, 2011 Apr.
Artículo
en Inglés
| MEDLINE
| ID: mdl-20615081
RESUMEN
When located in the DNA minor groove, dimeric bisbenzimidazoles DB(n) effectively inhibited in vitro the Dnmt3a catalytic domain (IC50 5-77 µM). The lowest IC50 value was observed for compound DB(11) with an 11-unit methylene linker joining the bisbenzimidazole fragments. Increased time of incubation of DNA with DB(n) as well as the presence of AT-clusters in DNA enhances the inhibitory effect.