[Substantiating the blood concentrations of phenol and alkylphenols (o-, m-, and p-cresols) providing the acceptable risk to human health].

The paper considers the current nontraditional approaches to revealing the causal effects and criteria for significance of an exposure-response relationship. The study has used the elements of methodology for assessing the risk and the techniques of environmental epidemiology to examine causal effects. A blood toxicant-response marker relationship was assessed and the quantitative characteristics of the association between the concentrations of the test compounds and the risk of noxious effects were ascertained. On the basis of exposure marker-response marker models, the authors revealed the priority types of functional changes and established the blood concentrations of phenol and m- and n-cresols at an acceptable risk level.