RESUMEN
A 63-year-old man underwent colonoscopy owing to a positive fecal occult blood test, and he was diagnosed as having advanced sigmoid colon cancer. Esophagogastroduodenoscopy( EGD), performed as a preoperative examination, revealed an 8 mm early gastric cancer in the lower body of his stomach. We performed laparoscopic sigmoid colon resection and D3 lymphadenectomy first because the patient had advanced sigmoid colon cancer. The histopathological diagnosis was Stage II; however, vascular invasion was apparent. Some authors have reported that chemotherapy with 5-fluorouracil (FU) is effective against early gastric cancer; therefore, we administered postoperative adjuvant chemotherapy comprising uracil and tegafur( UFT)+Leucovorin( LV) tablets before ESD for early gastric cancer. Two months later, follow-up EGD showed that the gastric cancer had become flat and small. Five months later, it resembled a scar, and examination of a biopsy showed no malignant finding. We continued to administer chemotherapy to the patient for 6 months. Nine months after the discontinuation of chemotherapy, EGD showed only a scar and biopsy revealed no malignant finding.
Asunto(s)
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Neoplasias Primarias Múltiples/tratamiento farmacológico , Neoplasias del Colon Sigmoide/complicaciones , Neoplasias Gástricas/tratamiento farmacológico , Quimioterapia Adyuvante , Humanos , Masculino , Persona de Mediana Edad , Estadificación de Neoplasias , Neoplasias del Colon Sigmoide/tratamiento farmacológico , Neoplasias del Colon Sigmoide/patología , Neoplasias del Colon Sigmoide/cirugía , Neoplasias Gástricas/patologíaRESUMEN
An 82-year-old female with unresectable colon cancer accompanied by multiple lung metastasis was treated with S-1. Our course consisted of S-1(80 mg/body)from day 1 to 5 followed by 2 days rest. After 14 courses, multiple lung metastasis decreased in size. After 20 courses, the multiple lung metastasis disappeared and local recurrence of colon cancer decreased. Weekly S-1 leads to a partial response. Our chemotherapy showed simple and good compliance for a patient over 80 years old.
Asunto(s)
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Neoplasias del Colon/tratamiento farmacológico , Neoplasias del Colon/patología , Neoplasias Pulmonares/tratamiento farmacológico , Neoplasias Pulmonares/secundario , Recurrencia Local de Neoplasia/tratamiento farmacológico , Ácido Oxónico/uso terapéutico , Tegafur/uso terapéutico , Anciano de 80 o más Años , Camptotecina/administración & dosificación , Camptotecina/análogos & derivados , Camptotecina/uso terapéutico , Neoplasias del Colon/cirugía , Combinación de Medicamentos , Femenino , Humanos , Irinotecán , Neoplasias Pulmonares/diagnóstico por imagen , Neoplasias Pulmonares/patología , Recurrencia Local de Neoplasia/patología , Ácido Oxónico/administración & dosificación , Tegafur/administración & dosificación , Tomografía Computarizada por Rayos X , Insuficiencia del TratamientoRESUMEN
A 71-year-old woman was admitted to our hospital with prominent abdominal distention. The diagnosis of systemic sclerosis (SSc) was made based on the sclerosis on her face, forearms, fingers, and toes as well as pitting ulcers on fingers and toes. After conservative therapy, she presented more severe signs of peritoneal irritation. Abdominal surgery was performed, revealing stenosis at the terminal ileum. Pathologically, this region showed muscularis propria becoming fibrotic. She was discharged from the hospital, returning about once a month as an outpatient.