RESUMEN
BACKGROUND: The gratification each person seeks through a movie is different. Sometimes a person would seek information through movies or use them for educational purposes, and some might watch movies to escape into a world of fantasy or humour. Keeping in mind the diverse and ever-changing needs of the audience, the primary objective of this study is to observe the evolution of movie genre and content preference in India, which is one of the largest and culturally intriguing movies producing nation across the globe. METHODS: To attain the objective, the researchers have thematically analysed the top five revenue grossing movie genres over a span of 26 years (1994 to 2019) in Bollywood. More than 100 storylines have been analysed to develop genre trend graphs and the results indicate a sharp decline in the popularity of romantic and family dramas, whereas comedy and action movies have witnessed an overall growth with romantic comedies (romcoms), being the most stable amongst the top five. RESULTS: Several societal factors like the changing family structure, education level, access to dating applications and even terrorism have been considered to elucidate the evolving psyche of the audience. The theoretical understanding of the result is derived from the uses and gratification theory, cross culture communication theory, and Bandura's social cognitive theory. Conclusions: This study would provide film-makers with a guide to understanding the changing movie genre preferences in India, which in turn would help them to produce economically profitable movies in future.
RESUMEN
The present study investigates the brain-targeted efficiency of atomoxetine (AXT)-loaded nanostructured lipid carrier (NLC)-laden thermosensitive in situ gel after intranasal administration. AXT-NLC was prepared by the melt emulsification ultrasonication method and optimized using the Box-Behnken design (BBD). The optimized formulation (AXT-NLC) exhibited particle size PDI, zeta potential, and entrapment efficiency (EE) of 108 nm, 0.271, -42.3 mV, and 84.12%, respectively. The morphology of AXT-NLC was found to be spherical, as confirmed by SEM analysis. DSC results displayed that the AXT was encapsulated within the NLC matrix. Further, optimized NLC (AXT-NLC13) was incorporated into a thermosensitive in situ gel using poloxamer 407 and carbopol gelling agent and evaluated for different parameters. The optimized in situ gel (AXT-NLC13G4) formulation showed excellent viscosity (2532 ± 18 Cps) at 37 °C and formed the gel at 28-34 °C. AXT-NLC13-G4 showed a sustained release of AXT (92.89 ± 3.98% in 12 h) compared to pure AXT (95.47 ± 2.76% in 4 h). The permeation flux through goat nasal mucosa of AXT from pure AXT and AXT-NLC13-G4 was 504.37 µg/cm2·h and 232.41 µg/cm2·h, respectively. AXT-NLC13-G4 intranasally displayed significantly higher absolute bioavailability of AXT (1.59-fold higher) than intravenous administration. AXT-NLC13-G4 intranasally showed 51.91% higher BTP than pure AXT (28.64%) when administered via the same route (intranasally). AXT-NLC13-G4 showed significantly higher BTE (207.92%) than pure AXT (140.14%) when administered intranasally, confirming that a high amount of the AXT reached the brain. With the disrupted performance induced by L-methionine, the AXT-NLC13-G4 showed significantly (p < 0.05) better activity than pure AXT as well as donepezil (standard). The finding concluded that NLC in situ gel is a novel carrier of AXT for improvement of brain delivery by the intranasal route and requires further investigation for more justification.