Effect of increased repetition time TR on precision of inversion-recovery T(1) measurements.

The effect of increased repetition time, TR, on the precision of inversion-recovery measurements of the spin-lattice relaxation time, T(1), was calculated theoretically, simulated numerically, and measured experimentally. All three methods yielded similar results. With constant inversion times, the T(1) precision was independent of TR. Therefore, 1) multiple-slice inversion-recovery fast-spin-echo T(1) maps should be made one slice at a time, not with interleaved acquisition, and 2) once the longest inversion time t(i) has been set, TR should be set just enough longer than the longest t(i) to allow data acquisition.

Correcting for incomplete saturation and off-resonance effects in multiple-site saturation-transfer kinetic measurements.

The effects of incomplete saturation and off-resonance irradiation on nuclear magnetic resonance saturation-transfer measurements of three-site chemical-exchange rates are discussed. A new method that uses double-saturation measurements is compared with two published methods, one that uses single-saturation measurements and one that uses a single-saturation measurement and a double-saturation measurement. Several formulas are compared for measuring the exchange rate constant k(DE) for exchange from a detected spin D to an exchanging spin E in the presence of exchange from spin D to a competing spin C. For each method, formulas are derived with corrections for incomplete saturation or off-resonance effects, with both corrections, and with neither correction. Exact formulas are available for three exchanging sites with incomplete saturation if there are no off-resonance effects. Off-resonance corrections are imperfect even with complete saturation.

Corrections for off-resonance effects and incomplete saturation in conventional (two-site) saturation-transfer kinetic measurements.

The effects of off-resonance irradiation and incomplete saturation on saturation-transfer measurements of chemical-exchange rates are discussed. With off-resonance effects there is no exact formula for the exchange rate constant from spin D to spin E, k(DE), in terms of observable signal intensities and relaxation rates. However, k(DE) can be estimated by measuring the effective spin-lattice relaxation rate constant of spin D when spin E is saturated, *R(1), plus signal intensities with no RF irradiation, M(0D) and M(0E); with irradiation of a control position, M'(D) and M'(E); and with saturation of spin E, *M(D) and *M(E). Several formulas are compared and the best formula for calculating k(DE) appears to be either k(DE) = *R(1) [(M'(D)- *M(D))/M(0D)]/[(M'(E) - *M(E))/M(0E)], or the same formula with M(0D) and M(0E) replaced by M'(D) and M'(E). These formulas are exact with incomplete saturation and no off-resonance effects, and are better than previously published formulas when off-resonance effects are present. More accurate formulas are available if signal intensities and relaxation rates can be measured while the exchange process is stopped. Magn Reson Med 43:810-819, 2000.

Effect of sample numbers on the kinetic data analysis of MR contrast agents.

The Monte Carlo simulation method is used to determine the uncertainties of the estimated are and mean transit time (MTT) of a regional cerebral concentration-time curve of a bolus injected paramagnetic contrast agent. Many factors contribute to these uncertainties. This study concentrates on the error propagation from the sample noise at different sample time points along the concentration-time curve. The uncertainties of area and MTT were determined as a function of the sample noise and the number of sample time points. For example, the percentage standard deviations (uncertainties) of both area and MTT are less than 12% with five samples whose signal-to-noise ratios are greater than 50.