Distribution of cocaine on banknotes in general circulation in England and Wales.

A study of the quantities of cocaine on banknotes in general circulation was conducted to investigate regional variations across England and Wales. No meaningful support was found for the proposition that there is regional variation in the quantities of cocaine in banknotes in general circulation in England and Wales.

Hypervigilance for fear after basolateral amygdala damage in humans.

Recent rodent research has shown that the basolateral amygdala (BLA) inhibits unconditioned, or innate, fear. It is, however, unknown whether the BLA acts in similar ways in humans. In a group of five subjects with a rare genetic syndrome, that is, Urbach-Wiethe disease (UWD), we used a combination of structural and functional neuroimaging, and established focal, bilateral BLA damage, while other amygdala sub-regions are functionally intact. We tested the translational hypothesis that these BLA-damaged UWD-subjects are hypervigilant to facial expressions of fear, which are prototypical innate threat cues in humans. Our data indeed repeatedly confirm fear hypervigilance in these UWD subjects. They show hypervigilant responses to unconsciously presented fearful faces in a modified Stroop task. They attend longer to the eyes of dynamically displayed fearful faces in an eye-tracked emotion recognition task, and in that task recognize facial fear significantly better than control subjects. These findings provide the first direct evidence in humans in support of an inhibitory function of the BLA on the brain's threat vigilance system, which has important implications for the understanding of the amygdala's role in the disorders of fear and anxiety.

Advances in seeded ambient temperature ferrite formation for treatment of acid mine drainage.

Advances in the seeded ambient temperature ferrite process for treatment of acid mine drainage (AMD) are described. Magnetite formation requires that the oxidation rate of ferrous to ferric does not exceed the rate at which ferrous iron is incorporated into the crystal structure (dehydroxylation-crystallization). If the oxidation rate is too high, then ferric-only oxides form, an effect exacerbated by the presence of calcium. NaOH was used to raise the pH of simulated AMD, which also contained calcium so as to simulate the use of lime (i.e., the dissolved Ca/ Fe2+ concentration was maintained at 1:1 bythe coaddition of CaCl2 because this is the Ca/Fe ratio that occurs when pH is elevated by the dissolution of lime). Raising the pH to 10.5 causes Fe2+ to precipitate as "ferrous intermediate" (FI), which is then partially oxidized to magnetite (Fe2+Fe3+2O4). The inhibitory effect of calcium is overcome by a combination of magnetite seed particles, high FI concentrations, and aging. High FI concentrations are easily obtained, even from AMD low in Fe2+, by a contact stabilization reactor-settler sequence. Results for simultaneous removal of cobalt, a metal found in significant concentrations in South African AMD, are also presented.

An examination of injuries in major league soccer. The inaugural season.

We analyzed the injury data collected from the 10 teams (237 players) that constituted Major League Soccer during its inaugural season. The overall injury rate was 6.2 per 1000 hours of participation. An injury rate of 2.9 per 1000 hours was noted for practice and 35.3 per 1000 hours was found for games. The difference was statistically significant. With regard to severity, 36% of injuries (143 of 399) were categorized as an incident (no time lost from competition). Of the 256 injuries that caused the player to lose playing time, 59% were classified as minor (<7 days lost), 28% as moderate (7 to 29 days lost), and 13% as major (>30 days lost). Seventy-seven percent of the injuries (197 of 256) were to the lower extremity; most frequently affected were the knee (N = 54) and ankle (N = 46). Neither the player's age nor playing position was found to be associated with prevalence or severity of injury. We believe that this information serves to underscore the notion that soccer, as it is played at the professional level, is a sport with a relatively low incidence of injury.

Patellofemoral arthrosis: the treatment options.

Patellofemoral arthritis is a relatively common and frequently complex problem encountered by those who treat patients with anterior knee pain. Because the pathologic conditions that precipitate this pain are so varied, the treatment options must also be varied. Using the Insall classification system for chondral injuries, we explored the treatment options available. Special emphasis was placed on grade IV changes and the surgical treatment of this condition. We reviewed the following options: spongialization, tibial tubercle elevation, patellectomy, patellar resurfacing, patellofemoral arthroplasty, and autologous chondrocyte transplantation. Regardless of the procedure favored, proper patellar tracking must be restored. Without such attention to patellar alignment, patients cannot achieve pain-free function.

The BHAGL lesion: a new variant of anterior shoulder instability.

This article describes a new lesion associated with anterior instability of the shoulder. The bony humeral avulsion of the glenohumeral ligaments (BHAGL) is a rare lesion that may occur after anterior dislocation of the shoulder. There is a bone fragment noted on radiographs of the shoulder that may appear similar to a bony glenoid avulsion. Computed tomography typically will show that the bone is attached to the glenohumeral ligaments and does not originate from the glenoid. Arthroscopy may or may not show the lesion. This variant of anterior shoulder instability may present with impingement or instability symptoms. If symptoms fail to respond to conservative management, treatment through open excision of the bony fragment and reattachment of the glenohumeral ligaments to their origin on the anterior aspect of the humerus is indicated.

Experience with penile fractures in Saudi Arabia.

Seven patients with penile rupture were treated surgically within a 9-month period. All were operated on as emergencies, with successful results, except in 1 case which was associated with urethral rupture. Sexual performance was satisfactory in 6 of 7 cases.