[The action of the alkanol ammonium salts of aroxyacetic acids on the thrombocyte aggregation process]. / Deistvie alkanolammonievykh solei aroksiuksusnykh kislot na protsess agregatsii trombotsitov.

Tris(2-hydroxyethyl)ammoniates of ezo-substituted aroxyalkane-carboxylic acids were examined for their effects on in vitro platelet aggregation under the influence of biogenic amines, as well as in lipid peroxidation. Hemocoagulation was evaluated in vivo. The agents tested were demonstrated no be a promising class of platelet aggregation inhibitors. They possess antioxidative effects, by reducing the level of malonic dialdehyde in induced hyperaggregation and the rate of lipid peroxidation. When given to animals, the agents decreased the activity of prothrombin factors.