[Screening for depression in patients with medical hospitalization. Comparison of two self-evaluation scales and clinical assessment with a structured questionnaire]. / Dépistage de la dépression chez les patients hospitalisés en médecine. Comparaison de deux échelles d'autoévaluation et du jugement des cliniciens à un questionnaire structuré.

The aim of this study was to determine, in a population of medical inpatients, the sensitivity, specificity, positive and negative predictive values of two self-rating depression scales, and of the physicians' judgment, compared to a structured interview derived from the Composite Interview Diagnostic Interview (CIDI) designed to assess the diagnosis of major depressive episodes. The setting of the study was a general internal medicine inpatient ward of a French university hospital. Patients between 15 and 75 were asked to fill, within the first week of their hospitalization, two self-rating depression scales: the Beck Depression Inventory - short form (BDI-short form), a 13-item scale with established reliability and validity; and the Center for Epidemiologic Studies-Depression Scale (CES-D), a 20-item scale designed for epidemiological use in the general population, recently translated in French. Patients were then interviewed by a psychologist, blind to the results of the self-rating scales, using a slightly simplified version of the depression section of the CIDI. The ward physicians' recognition of depression was assessed six months later by a careful chart review, conducted by an investigator blind to the results of depression scales and structured interview. One hundred consecutive patients were studied: 63% were women, mean age was 53.6 +/- 16.5 years. According to the results of the CIDI, the prevalence of current major depression was 29.7%, and the lifetime prevalence of major depression was 59.8%. The correlation between BDI-short form and CES-D was +0.81. BDI-short form proved to have a slightly better acceptability than the CES-D.(ABSTRACT TRUNCATED AT 250 WORDS)

Both Epstein-Barr virus (EBV)-encoded trans-acting factors, EB1 and EB2, are required to activate transcription from an EBV early promoter.

We have identified two Epstein--Barr virus (EBV) transacting factors which are involved in the transcriptional activation of EBV early promoters in latently infected Raji cells. In Raji cells, expression of the factor EB1 encoded by the open reading frame (ORF) BZLF1 is necessary and sufficient to disrupt latency. However, factor EB2 encoded by the ORF BMLF1- BSLF2 does not disrupt latency when expressed alone in Raji cells. Expression of an EBV activatable early promoter depends on the presence of both EB1 and EB2.