A detailed multi-omics analysis of GNB2 gene in human cancers / Uma análise multiômica detalhada do gene GNB2 em cânceres humanos

The Guanine-nucleotide binding protein 2 (GNB2) encodes for β2 subunit (Gβ2) of the G-protein complex. Keeping in view the increased demand of reliable biomarkers in cancer, the current study was planned to extensively explored GNB2 expression variation and its roles in different cancers using online available databases and diverse methodology. In view of our results, the GNB2 was notably up-regulated relative to corresponding controls in twenty three cancer types. As well, the elevated expression of GNB2 was found to be associated with the reduced overall survival (OS) of the Liver Hepatocellular Carcinoma (LIHC) and Rectum Adenocarcinoma (READ) only out of all analyzed cancer types. This implies GNB2 plays vital role in the tumorigenesis of LIHC and READ. Several additional analysis also explored six critical pathways and few important correlations related to GNB2 expression and different other parameters such as promoter methylation, tumor purity, CD8+ T immune cells infiltration, and genetic alteration, and chemotherapeutic drugs. In conclusion, GNB2 gene has been identified in this study as a shared potential biomarker (diagnostic and prognostic) of LIHC and READ.

A proteína 2 de ligação de nucleotídeos de guanina (GNB2) codifica a subunidade β2 (Gβ2) do complexo da proteína G. Tendo em vista o aumento da demanda de biomarcadores em câncer, o presente estudo foi planejado para explorar extensivamente a variação da expressão de GNB2 e seus papéis em diferentes cânceres usando bancos de dados on-line disponíveis e metodologia diversificada. Em vista de nossos resultados, o GNB2 foi notavelmente regulado para cima em relação aos controles correspondentes em 23 tipos de câncer. Além disso, a expressão elevada de GNB2 foi associada à redução da sobrevida global (OS) do carcinoma hepatocelular do fígado (LIHC) e do adenocarcinoma do reto (READ) apenas em todos os tipos de câncer analisados. Isso implica que GNB2 desempenha um papel vital na tumorigênese de LIHC e READ. Várias análises adicionais também exploraram seis vias críticas e poucas correlações relacionadas à expressão de GNB2 e diferentes outros parâmetros, como metilação do promotor, pureza do tumor, infiltração de células T CD8+, alteração genética e drogas quimioterápicas. Em conclusão, o gene GNB2 foi identificado neste estudo como um potencial biomarcador compartilhado (diagnóstico e prognóstico) de LIHC e READ.

A detailed multi-omics analysis of GNB2 gene in human cancers.

The Guanine-nucleotide binding protein 2 (GNB2) encodes for ß2 subunit (Gß2) of the G-protein complex. Keeping in view the increased demand of reliable biomarkers in cancer, the current study was planned to extensively explored GNB2 expression variation and its roles in different cancers using online available databases and diverse methodology. In view of our results, the GNB2 was notably up-regulated relative to corresponding controls in twenty three cancer types. As well, the elevated expression of GNB2 was found to be associated with the reduced overall survival (OS) of the Liver Hepatocellular Carcinoma (LIHC) and Rectum Adenocarcinoma (READ) only out of all analyzed cancer types. This implies GNB2 plays vital role in the tumorigenesis of LIHC and READ. Several additional analysis also explored six critical pathways and few important correlations related to GNB2 expression and different other parameters such as promoter methylation, tumor purity, CD8+ T immune cells infiltration, and genetic alteration, and chemotherapeutic drugs. In conclusion, GNB2 gene has been identified in this study as a shared potential biomarker (diagnostic and prognostic) of LIHC and READ.