RESUMEN
As with other organ transplants even lung transplantation raises the question of the possibility of the influence of gender on ischemia-reperfusion injury. This is a current topic especially for increasingly utilized method of lung transplantation from non-heart-beating donors, where reperfusion preceded by a period of warm and cold ischemia with subsequent treatment options for lung graft reperfusion. For measurements we used our laboratory previously created and validated animal model for ex vivo lung transplantation. As with other organ systems of our monitoring resulted protective effect of female sex on ischemia reperfusion lung injury. In two of the three parameters that were monitored, we found a significant difference. In females, higher oxygen transfer ability after reperfusion was manifested as well as lower perfusion pressure (vascular compliance). Conversely, weight gain (the development of pulmonary edema) in males was not significant difference from the females. These conclusions could cause further studies leading to influence the selection of appropriate donor grafts.
Asunto(s)
Enfermedades Pulmonares/patología , Daño por Reperfusión/patología , Animales , Presión Sanguínea , Modelos Animales de Enfermedad , Femenino , Rendimiento Pulmonar , Trasplante de Pulmón/métodos , Masculino , Consumo de Oxígeno , Circulación Pulmonar , Ratas , Ratas Wistar , Especies Reactivas de Oxígeno/metabolismo , Caracteres Sexuales , Resistencia Vascular , Aumento de PesoRESUMEN
Intramural hematoma of the oesophagus is a rare diagnosis presenting with retrosternal pain, dysphagia and haematemesis. It is caused by barotrauma or direct injury to the esophagus, or it may occur spontaneously without apparent cause, which is more common in patients taking antiplatelet or anticoagulant medications. In most cases, treatment is conservative. Rarely, endoscopic, endovascular or surgical treatment is effective. This article presents a case report of a female patient with spontaneous haematoma of the oesophagus solved conservatively and discusses further possibilities of the course and treatment of the disease.Key words: intramural haematoma of the oesophagus IHE.