RESUMEN
We studied the effect of Semax on the state of intestinal microbiota in rats subjected to restraint stress. Semax was injected to Wistar male rats intraperitoneally in doses of 5, 50, 150, 450 µg/kg 12-15 min before modelling chronic restraint stress. It was found that stress exposure reduced the number of obligate bacteria in the colon microbiota, but increased the content of opportunistic microorganisms. Semax in doses of 50 and 150 µg/kg prevented the stress-induced changes in the composition of colon microbiota. The observed effects of Semax might be mediated by the central neurotropic effects as well as by binding to peripheral melanocortin receptors of the intestine.
Asunto(s)
Hormona Adrenocorticotrópica/análogos & derivados , Colon/efectos de los fármacos , Colon/microbiología , Microbioma Gastrointestinal/efectos de los fármacos , Fragmentos de Péptidos/uso terapéutico , Hormona Adrenocorticotrópica/uso terapéutico , Animales , Modelos Animales de Enfermedad , Masculino , Ratas , Ratas Wistar , Restricción Física , Estrés Fisiológico/efectos de los fármacosRESUMEN
We studied the effects of Selank on the condition of the colon wall in Wistar male rats subjected to restraint stress. Selank was injected intraperitoneally in doses of 80, 250, and 750 µg/kg 15 min before stress exposure. In rats subjected to stress, signs of atrophy, inflammatory reaction, and changes in the number and functional activity of mast cells were observed against the background of increased corticosterone level. Selank administration led to a decrease in corticosterone levels, reduced pathomorphological manifestations of stress exposure, and accelerated adaptation. These effects were presumably realized due to multifunctional biological effects of Selank.
Asunto(s)
Oligopéptidos/uso terapéutico , Animales , Colon/efectos de los fármacos , Colon/metabolismo , Corticosterona/metabolismo , Modelos Animales de Enfermedad , Masculino , Mastocitos/efectos de los fármacos , Mastocitos/metabolismo , Ratas , Ratas Wistar , Restricción Física , Estrés Fisiológico/efectos de los fármacosRESUMEN
We studied the effects of Selank on intestinal microbiota in Wistar male rats subjected to chronic restraint stress. Selank was injected intraperitoneally in doses of 80, 250 and 750 µg/kg 15 min before stress exposure. Chronic restraint stress led to a decrease in the content of obligate microflora, while the content of opportunistic microorganisms increased. Selank restored intestinal microbiota presumably via central (neurotropic) and peripheral (immunotropic) mechanisms.
