RESUMEN
PURPOSE: The aim of this study was to review the clinical profile including predisposing systemic conditions, microorganisms responsible, clinical presentation, and outcomes of endogenous endophthalmitis (EE) in South India. DESIGN: This study is a retrospective, noncomparative case series. METHODS: This study presents a retrospective analysis of records of patients with EE in a 10-year period. RESULTS: A total of 61 eyes of 58 patients were included in the study. Preceding systemic illness or surgery was noted in 31 patients (53.4%). No predisposing condition was found in 27 patients (46.5%). All eyes had severe diffuse EE. Culture positivity was seen in 34 of 58 patients (58.6%). Gram-positive organisms were isolated in 9 cases (15.5%), and Gram-negative organisms were isolated in 20 cases (34.5%). Pseudomonas aeruginosa (13.8%) was the most common isolate. Eleven eyes (18%) were managed medically with intravenous and intravitreal antibiotics, and 38 eyes (62.3%) also underwent vitrectomy. Eight eyes (13.1%) required repeat vitrectomy, and 12 eyes (19.7%) were eviscerated. The mean follow-up was 16.2 ± 13.9 months. Final visual acuity of 20/200 or better was seen in 29.5% eyes. A favorable outcome was noted in culture-positive patients (P = 0.03) and in patients with no predisposing causes. CONCLUSIONS: This study provides information about the clinical and microbiologic profile of EE. Aggressive medical and surgical treatment can result in favorable outcomes.
Asunto(s)
Bacteriemia/microbiología , Endoftalmitis/microbiología , Infecciones Bacterianas del Ojo/microbiología , Adolescente , Adulto , Anciano , Antibacterianos/uso terapéutico , Humor Acuoso/microbiología , Bacteriemia/diagnóstico , Bacteriemia/terapia , Bacterias/aislamiento & purificación , Terapia Combinada , Endoftalmitis/diagnóstico , Endoftalmitis/terapia , Evisceración del Ojo , Infecciones Bacterianas del Ojo/diagnóstico , Infecciones Bacterianas del Ojo/terapia , Femenino , Humanos , India , Inyecciones Intravenosas , Inyecciones Intravítreas , Masculino , Persona de Mediana Edad , Reacción en Cadena de la Polimerasa , Estudios Retrospectivos , Factores de Riesgo , Centros de Atención Terciaria , Agudeza Visual/fisiología , Vitrectomía , Cuerpo Vítreo/microbiologíaRESUMEN
We report a rare case of Bietti's crystalline dystrophy presenting with choroidal neovascular membrane (CNVM) which was treated with three injections of intravitreal ranibizumab. The CNVM underwent scarring after the injections with stabilization of visual acuity at a follow-up period of 12 months suggesting that intravitreal ranibizumab may have a role in the management of CNVM in these rare cases.
Asunto(s)
Anticuerpos Monoclonales Humanizados/administración & dosificación , Neovascularización Coroidal/tratamiento farmacológico , Distrofias Hereditarias de la Córnea/complicaciones , Enfermedades de la Retina/complicaciones , Adulto , Neovascularización Coroidal/diagnóstico , Neovascularización Coroidal/etiología , Distrofias Hereditarias de la Córnea/diagnóstico , Diagnóstico Diferencial , Relación Dosis-Respuesta a Droga , Electrorretinografía , Angiografía con Fluoresceína , Estudios de Seguimiento , Fondo de Ojo , Humanos , Inyecciones Intravítreas , Masculino , Ranibizumab , Enfermedades de la Retina/diagnóstico , Tomografía de Coherencia Óptica , Agudeza VisualRESUMEN
PURPOSE: The purpose of this study was to report the efficacious use of intravitreal ranibizumab in the management of postfungal endophthalmitis scar-related choroidal neovascular membrane. METHODS: This is an interventional case report. RESULTS: The patient's visual acuity was stabilized and membrane activity ceased after treatment with three injections of intravitreal ranibizumab at monthly intervals. CONCLUSION: Intravitreal ranibizumab can be useful in the treatment of inflammatory scar-related choroidal neovascular membrane.
