RESUMEN
We describe two unrelated patients and the mother of one of them showing clinical and radiological features as those previously described in the spondyloepiphyseal dysplasia-brachydactyly and distinctive speech (SED-BDS, also named Fantasy Island syndrome or Tattoo dysplasia) clinically characterized by short stature with acral shortness, distinctive face, mild blepharophimosis, upslanted palpebral fissures, abundant eyebrows and eyelashes, thick and abundant hair and coarse voice; and radiologically by brachymetacarpalia, brachymetatarsalia and brachyphalangia of all fingers and toes, short and broad long bones with normal morphology and small pelvis. The clinical and radiological features present in mother and son suggest a probable autosomal dominant mode of inheritance and variable expressivity.
Asunto(s)
Anomalías Múltiples , Dedos/anomalías , Trastornos del Habla , Dedos del Pie/anomalías , Anomalías Múltiples/genética , Adolescente , Adulto , Preescolar , Enanismo/genética , Facies , Femenino , Enfermedades Genéticas Ligadas al Cromosoma X , Cabello , Humanos , Masculino , Trastornos del Habla/genética , SíndromeRESUMEN
We report on 5 sibs (4 males, 1 female) with growth retardation, severe pelvic hypoplasia, arthrogrypotic changes and muscular hypotrophy of the lower limbs, and mild vertebral changes of prenatal onset. To our knowledge, this syndrome has not yet been reported. The family history suggests autosomal-recessive inheritance.
Asunto(s)
Artrogriposis/genética , Retardo del Crecimiento Fetal/genética , Deformidades Congénitas de las Extremidades/genética , Pelvis/anomalías , Adolescente , Adulto , Niño , Contractura/genética , Femenino , Deformidades Congénitas del Pie/genética , Genes Recesivos , Humanos , Masculino , Linaje , Pelvis/diagnóstico por imagen , RadiografíaRESUMEN
The hypertrichosis and osteochondrodysplasia syndrome is a rare entity with clinical findings including macrosomia at birth cardiomegaly. Autosomal recessive inheritance is presumed based on the report of two affected sibs born to healthy parents. Here we report on four new patients with their follow-up data, as well as on one of the four cases from the original report. Comparison of all eight cases indicates that they share 50% of clinical and radiological changes. This report contributes to the further delineation of this newly recognized syndrome.
Asunto(s)
Anomalías Múltiples/genética , Cardiomegalia/congénito , Hipertricosis/congénito , Osteocondrodisplasias/congénito , Adolescente , Cardiomegalia/diagnóstico , Cardiomegalia/genética , Niño , Preescolar , Femenino , Humanos , Hipertricosis/diagnóstico , Hipertricosis/genética , Masculino , Osteocondrodisplasias/diagnóstico , Osteocondrodisplasias/diagnóstico por imagen , Osteocondrodisplasias/genética , Fenotipo , Radiografía , Síndrome , Rayos XRESUMEN
A father and son with unusual congenital skeletal symptoms, mainly characterized by short stature and epiphyseal dysplasia limited to the femoral heads are described. The comparative analysis with other spondyloepiphyseal dysplasias supports the notion that the syndrome reported here is a distinct autosomal dominant connective tissue disorder.
Asunto(s)
Aberraciones Cromosómicas/genética , Epífisis/anomalías , Cabeza Femoral/anomalías , Genes Dominantes/genética , Osteocondrodisplasias/genética , Adulto , Trastornos de los Cromosomas , Enanismo/diagnóstico por imagen , Enanismo/genética , Epífisis/diagnóstico por imagen , Cabeza Femoral/diagnóstico por imagen , Humanos , Lactante , Masculino , Osteocondrodisplasias/diagnóstico por imagen , RadiografíaRESUMEN
An 8-year-old male patient presented a unique pattern of congenital anomalies. Prominent findings included a combination of severe osteoporosis and congenital oculocutaneous hypopigmentation. The patient may represent a hitherto undescribed syndrome of unknown etiology.
Asunto(s)
Albinismo Oculocutáneo , Osteoporosis , Adulto , Niño , Deformidades de la Mano/diagnóstico por imagen , Humanos , Masculino , Persona de Mediana Edad , Desempeño Psicomotor , Radiografía , Síndrome , Trastornos de la VisiónRESUMEN
We studied a mother and daughter with skeletal dysplasia which was characterized clinically by proximal and distal flexion contractures in the phalanges, and by brachydactyly, clinodactyly and ulnar and radial subdislocations of the fingers. Radiologically, the 2nd metacarpal in the daughter was seen to be longer than the other metacarpals, with bone carpal fusion, and flexion contractures of the fingers in both hands. Thoraco-lumbar xyphorotoscoliosis and malformed vertebrae with dyssegmentation of L2-L3, T12 and L1 with cuneiform shape, asymmetry of the pelvic bones and exostotic lesions in the proximal third of the tibia and the distal third of the femur were also noted. The clinical and radiological characteristics were compatible with the syndrome described by Christian et al. in 1975 and called the second metatarsal syndrome. The purpose of this paper was to present a second corroborative familial case and to propose another name: Christian's spondylo-digital syndrome.
Asunto(s)
Dedos/anomalías , Osteocondrodisplasias/patología , Dedos del Pie/anomalías , Adolescente , Femenino , Humanos , Persona de Mediana EdadRESUMEN
We describe seven patients from two Mexican families with congenital macroglossia. Comparative analysis of these cases and the patients previously described in literature, allows to confirm the notion that this isolated primary macroglossia is a distinct dominant condition.
Asunto(s)
Genes Dominantes/genética , Macroglosia/genética , Adulto , Diagnóstico Diferencial , Femenino , Estudios de Seguimiento , Humanos , Lactante , Cariotipificación , Masculino , Linaje , Embarazo , SíndromeRESUMEN
We describe four members of a family in which the clinical and radiological findings lead to consider the diagnosis of osteopoikilosis. The symptoms in all affected members were only those referred to as typical radiological features; these features became more extensive with older age. None of the subjects showed the skin lesions reported in the Buschke-Ollendorff syndrome. The importance of a suitable differential diagnosis is emphasized in order to avoid dangerous and unnecessary treatments.
Asunto(s)
Aberraciones Cromosómicas/genética , Genes Dominantes/genética , Osteopoiquilosis/genética , Adulto , Huesos/diagnóstico por imagen , Trastornos de los Cromosomas , Femenino , Tamización de Portadores Genéticos , Humanos , Osteopoiquilosis/diagnóstico por imagen , Linaje , Fenotipo , RadiografíaRESUMEN
Data on 113,913 liveborn children from a hospital in Guadalajara, Jalisco (Mexico), were analysed for birth defects (BD); mutation rates were calculated for sporadic aneuploidy, chromosome aberrations and dominant gene mutations. The results showed a general incidence of 13.92 BD cases per 1000 liveborns, of which 1.64% were chromosomal abnormalities, 1.50% were aneuploid, 0.14% were structural chromosome aberrations and 3.23% were dominant gene mutations. The mutation rates were 8.20 x 10(-4) chromosomal abnormalities, 7.5 x 10(-4) aneuploidies, 7.0 x 10(-5) chromosome aberrations and 1.61 x 10(-3) dominant gene mutations/gamete/generation, respectively. The lethality rate was 15.32% of the liveborns with BD. The described findings estimate the incidence of new human mutants detected at birth in a sample of the Mexican population. They show that the rate for some aneuploidies are similar to those found in other populations previously reported in the literature but the rates of chromosome and dominant gene mutations were different.
Asunto(s)
Aneuploidia , Aberraciones Cromosómicas , Anomalías Congénitas/epidemiología , Genes Dominantes , Mutación , Anomalías Congénitas/genética , Femenino , Humanos , Incidencia , Recién Nacido , Masculino , México/epidemiologíaRESUMEN
Three sisters with congenital glaucoma, peculiar facies and mild skeletal anomalies are described. It is concluded that such an aggregate of anomalies probably corresponds to a 'new' autosomal recessive syndrome.
Asunto(s)
Anomalías Múltiples/genética , Huesos/anomalías , Glaucoma/congénito , Adolescente , Huesos/diagnóstico por imagen , Niño , Huesos Faciales/anomalías , Femenino , Fondo de Ojo , Glaucoma/genética , Humanos , Iris/anomalías , Radiografía , SíndromeRESUMEN
A 4 9/12-year-old boy with achalasia microcephaly syndrome (AMS), born to a consanguineous couple, is reported. Comparative analysis of this case and the patients previously described in a Mexican family supports the notion that the syndrome is a distinct autosomal recessive condition. It is interesting that the area of origin and ethnicity of both the present and the previously reported cases is northwest Mexico.
Asunto(s)
Anomalías Múltiples/genética , Acalasia del Esófago/genética , Genes Recesivos , Microcefalia/genética , Consanguinidad , Humanos , Lactante , Discapacidad Intelectual/genética , Masculino , Linaje , SíndromeRESUMEN
An adult male patient with a "de novo" pure trisomy 1q32---q42 was studied. Literature review of 33 cases with 1q trisomy allowed singling out a distinctive phenotype by eliminating clinical features of concomitant aneusomies. It is concluded, however, that the clinical pictures of the "pure" and "impure" 1q trisomies are similar and that the critical segment includes bands q32 and q41.
Asunto(s)
Cromosomas Humanos Par 1 , Huesos Faciales/anomalías , Discapacidad Intelectual/genética , Cráneo/anomalías , Trisomía , Adulto , Humanos , Cariotipificación , Masculino , Fenotipo , SíndromeRESUMEN
A Mexican mestizo family is reported in which two opposite sexed sibs, born to consanguineous parents, had a skeletal dysplasia. The salient features were a bell shaped thorax owing to short ribs, short limbed dwarfism, pelvic hypoplasia, dislocatable radial heads, elongated distal fibulae, and improvement with age. It is concluded that the present observation probably represents a distinct autosomal recessive thoraco-limb dysplasia identifiable at birth.
Asunto(s)
Enfermedades del Desarrollo Óseo/genética , Preescolar , Consanguinidad , Enanismo/genética , Femenino , Genes Recesivos , Humanos , Lactante , Deformidades Congénitas de las Extremidades , Masculino , Costillas/anomalías , SíndromeRESUMEN
A syndrome characterized by progeroid facies, multiple nevi, mild mental retardation, skin hyperextensibility, bruisability, moderate skin fragility, joint hypermobility principally in digits, is described in two unrelated patients. Electron microscopy of the skin showed some fragmentation of the elastic fibers' portion and moderate electrodensity in the amorphous portion. Since a practically identical constellation of clinical features was previously reported in three patients, the individualization of a distinct connective tissue disorder, probably autosomal dominant, with variable expressivity is concluded.
Asunto(s)
Síndrome de Ehlers-Danlos/patología , Adolescente , Niño , Tejido Conectivo/patología , Síndrome de Ehlers-Danlos/genética , Humanos , Discapacidad Intelectual/genética , Masculino , Microscopía Electrónica , Progeria/genética , Piel/ultraestructuraRESUMEN
A 14-month-old female infant with a syndrome mainly consisting of cortical blindness, psychomotor retardation and postaxial polydactyly (type B in hands and type A in feet) was studied. Two deceased sibs were similarly affected. Differential diagnosis and the review of medical literature permit the individualization of a distinct syndrome with a probable autosomal recessive pattern of inheritance.
Asunto(s)
Ceguera/genética , Trastornos del Crecimiento/genética , Deformidades Congénitas de las Extremidades , Trastornos Psicomotores/genética , Consanguinidad , Femenino , Deformidades Congénitas del Pie , Genes Recesivos , Deformidades Congénitas de la Mano , Humanos , Lactante , Masculino , Linaje , SíndromeRESUMEN
Two sisters and an unrelated girl presented a distinct intrauterine growth retardation-malformation syndrome with short stature, microcephaly, pectus excavatum, hip dislocation, hypoplastic pubic region and genitalia, camptodactyly, talipes, shortened 2nd toes, hypoplastic patella and skeletal dysplasia probably due to homozygosity from an autosomal recessive gene.
Asunto(s)
Anomalías Múltiples/genética , Retardo del Crecimiento Fetal/genética , Dedos/anomalías , Preescolar , Dermatoglifia , Femenino , Humanos , Embarazo , SíndromeRESUMEN
A 16 year-old boy with monosomy 20p was studied. The clinical and radiological data compared with those from the three previously reported cases, permit the delineation of a distinct syndrome of low birthweight, flat face, low nasal bridge, long philtrum, short neck, small overfolded ears, chest deformity, kyphoscoliosis, congenital heart defect, hypoplastic or absent ribs and rachischisis (butterfly-shaped vertebral bodies). The critical chromosome segment causing this syndrome is tentatively defined as 20p13.
Asunto(s)
Anomalías Múltiples/genética , Deleción Cromosómica , Cromosomas Humanos 19-20 , Monosomía , Anomalías Múltiples/diagnóstico por imagen , Adolescente , Vértebras Cervicales/anomalías , Cardiopatías Congénitas/genética , Humanos , Masculino , Radiografía , Costillas/anomalíasRESUMEN
A two year-old boy with congenital malformations, psychomotor retardation and absence of phenotypical features of the Langer-Giedion syndrome (LGS) was found to have a de novo del (8) (q212q2200). The comparative analysis with other 8q monosomic cases suggests the existence of at least two distinct syndromes: one due to the monosomy of a part of the segment 8q22----q24, clinically manifested as the LGS, and the other to the deletion of the band 8q21.