High positive end-expiratory pressure ventilation mitigates the progression from unilateral pulmonary contusion to ARDS: An animal study.

BACKGROUND: Pulmonary contusion (PC) is common in severely traumatized patients and can lead to respiratory failure requiring mechanical ventilation (MV). Ventilator-induced lung injury (VILI) might aggravate lung damage. Despite underrepresentation of trauma patients in trials on lung-protective MV, results are extrapolated to these patients, potentially disregarding important pathophysiological differences. METHODS: Three MV protocols with different positive end-expiratory pressure (PEEP) levels: ARDSnetwork lower PEEP (ARDSnet-low), ARDSnetwork higher PEEP (ARDSnet-high), and open lung concept (OLC) were applied in swine for 24 hours following PC. Gas exchange, lung mechanics, quantitative computed tomography, and diffuse alveolar damage (DAD) score were analyzed. Results are given as median (interquartile range) at 24 hours. Statistical testing was performed using general linear models (group effect) over all measurement points and pairwise Mann-Whitney U tests for DAD. RESULTS: There were significant differences between groups: PEEP ( p < 0.0001) ARDSnet-low (8 [8-10] cmH 2 O), ARDSnet-high (12 [12-12] cmH 2 O), OLC (21 [20-22] cmH 2 O). The fraction of arterial partial pressure of oxygen and inspired oxygen fraction ( p = 0.0016) was lowest in ARDSnet-low (78 (73-111) mm Hg) compared with ARDSnet-high (375 (365-423) mm Hg) and OLC (499 (430-523) mm Hg). The end-expiratory lung volume (EELV) differed significantly ( p < 0.0001), with highest values in OLC (64% [60-70%]) and lowest in ARDSnet-low (34% [24-37%]). Costa's surrogate for mechanical power differed significantly ( p < 0.0001), with lowest values for ARDSnet-high (73 [58-76]) compared with OLC (105 [108-116]). Diffuse alveolar damage was lower in ARDSnet-high compared with ARDSnet-low (0.0007). CONCLUSION: Progression to ARDS, 24 hours after PC, was mitigated by OLC and ARDSnet-high. Both concepts restored EELV. ARDSnet-high had the lowest mechanical power surrogate and DAD. Our data suggest, that ARDSnet-high restored oxygenation and functional lung volume and reduced physiological and histological surrogates for VILI. ARDSnet-low generated unfavorable outcomes, such as loss of EELV, increased mechanical power and DAD after PC in swine. The high respiratory rate in the OLC may blunt favorable effects of lung recruitment.

Characteristics of different cathodic arc deposition coatings on CoCrMo for biomedical applications.

Coatings of endoprostheses are used to improve the tribological performance of arthroplasties. A major challenge for the successful use of these coatings, however, is a stable layer adhesion, a smooth surface, as well as a reduction in droplet formation during the coating process. Explants with commercially available coatings were investigated to assess surface/layer defects and adhesion properties. For the investigation of new coatings, we used cathodic arc deposition (Arc-PVD) to generate TiN, ZrN similar to the currently commercially available coatings and three different diamond like carbon (DLC) coatings on CoCrMo substrate. All surface coatings were mechanically specified by measuring roughness, coating thickness, abrasive wear and critical loads. A friction wear test was modified using an UHMWPE counterpart with a contact pressure of 10 MPa to compare different coatings in one tribological test setup. Calf serum was used as lubricant. The commercially used coatings on the retrieved explants show several defects and the critical load for coating failure varied widely. All produced surface coatings showed an increased surface roughness after coating compared to uncoated samples, which was due to droplet formation, especially in the DLC coatings. A diamond post-polishing process was performed to reduce the surface roughness and reach the ISO standard of Ra < 50 nm. The ZrN and TiN coatings exhibited a decreased friction after removing of the droplets in comparison to uncoated CoCrMo samples, indicating that the post-polishing process might be a useful tool to ameliorate the tribological performance. The friction coefficient for all tested DLC layers was more than two times increased compared to the CoCrMo samples. The use of hard/soft bearings with DLC coated endoprostheses seems to be not advantageous.