RESUMEN
BACKGROUND: The term "hebephilia" describes the sexual preference for minors at an early pubertal body age. For most clinicians the definition of hebephilia is not obvious and not integrated as a separate category in the DSM-5. METHOD: Nâ=â222 self-motivated applicants from the community for the therapy program of the Prevention Project Dunkelfeld in Berlin were assessed concerning their sexual preference towards minors. RESULTS: Approximately two-thirds (nâ=â153) showed a sexual interest in early pubertal minors (15â% exclusively; 85â% non-exclusively). Approximately 95â% reported having sexually abused children and/or having used child abusive images at least once in their lifetime. Hebephiles reported a significantly higher level of clinically relevant distress and personality characteristics, as well as more offense-supportive attitudes compared to normative samples. CONCLUSION: Hebephilia can be differentiated from pedophilia in terms of sexual interest for the body age of the minor. Associated personal distress, deviant personality characteristics as well as sexual behavior problems suggest that hebephilia can fulfill the criteria of a sexual disorder which should be considered in classification systems (DSM, ICD).
Asunto(s)
Pedofilia/psicología , Adolescente , Adulto , Factores de Edad , Niño , Abuso Sexual Infantil , Manual Diagnóstico y Estadístico de los Trastornos Mentales , Femenino , Educación en Salud , Humanos , Masculino , Pruebas Neuropsicológicas , Pedofilia/clasificación , Delitos Sexuales , Terminología como AsuntoRESUMEN
BACKGROUND: The term "hebephilia" describes the sexual preference for the body scheme of pubescent minors (Tanner stages 2 and 3). For most clinicians the definition of hebephilia as a sexual disorder is not obvious. METHOD: In all assessed males included in the Prevention Project Dunkelfeld at the Institute for Sexual Medicine at the Charité between 2005 and 2011, who met the inclusion criteria and showed no evidence for exclusion criteria (n=222), the existence of a hebephilia was examined. RESULTS: Approximately two thirds of the present sample (n=153) showed responsiveness for the body scheme of pubescent minors. Of these, only 15% were exclusively attracted by the pubescent body scheme and 85% were cases of mixed types. Concerning the clinical aspects of the sexual preference disorder, about 95% reported child sexual abuse and/or having used child abusive images at least once in their lifetime. Additionally, hebephiles reported a higher level of clinical/psychological stress and more distinct personality characteristics in relation to a comparative sample. In terms of risk factors, hebephiles showed more offense-supportive attitudes compared to a male comparative sample. CONCLUSION: Hebephilia is a sexual disorder, but cannot be independently coded in the presently valid classification systems (DSM-IV-TR and ICD-10). Plans to separately include this in future in the DSM-5 represent an important step from a sexological point of view.
Asunto(s)
Abuso Sexual Infantil/psicología , Pedofilia/psicología , Conducta Sexual , Disfunciones Sexuales Psicológicas/psicología , Adaptación Psicológica , Adolescente , Adulto , Imagen Corporal , Abuso Sexual Infantil/prevención & control , Manual Diagnóstico y Estadístico de los Trastornos Mentales , Femenino , Humanos , Clasificación Internacional de Enfermedades , Entrevista Psicológica , Masculino , Persona de Mediana Edad , Pruebas Neuropsicológicas , Personalidad , Escalas de Valoración Psiquiátrica , Factores de Riesgo , Estrés PsicológicoRESUMEN
This manuscript summarizes specific issues in the disease course and pharmacological treatment of women with bipolar disorders. Gender differences relevant to the female biology manifest in symptoms, outcome, and course. The preponderance of depressive symptoms is typical, and the risk of rapid cycling is estimated to be eight times higher for women than for men. Comorbid anxiety and eating disorders occur more frequently in female patients. In planning treatment it is important to take fertility, contraception, and pregnancy into consideration and adjust the pharmacotherapy to harmonize with the patient's current phase of life. Little is known about potential sexual dysfunctions of bipolar women. Further research should include clinical and observational studies focusing on gender-specific differences in symptomatology, treatment, and long-term outcome of bipolar disorders.
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Antidepresivos/administración & dosificación , Ansiedad/diagnóstico , Ansiedad/tratamiento farmacológico , Trastorno Bipolar/diagnóstico , Trastorno Bipolar/tratamiento farmacológico , Depresión/diagnóstico , Depresión/tratamiento farmacológico , Ansiedad/complicaciones , Trastorno Bipolar/complicaciones , Depresión/complicaciones , Femenino , Alemania , Humanos , Salud de la MujerRESUMEN
The risk of Henoch-Schönlein purpura (HSP) following vaccination with a group B meningococcal vaccine was assessed through active hospital safety monitoring. There was no increase in the relative incidence of HSP within 30 days after vaccination nor recurrence in HSP cases who received one or more further vaccine doses (re-challenge).
Asunto(s)
Erupciones por Medicamentos/etiología , Vasculitis por IgA/inducido químicamente , Vacunas Meningococicas/efectos adversos , Niño , Preescolar , Erupciones por Medicamentos/epidemiología , Femenino , Humanos , Vasculitis por IgA/epidemiología , Programas de Inmunización , Esquemas de Inmunización , Incidencia , Lactante , Masculino , Nueva Zelanda/epidemiología , Vacunación/efectos adversosRESUMEN
OBJECTIVES: To compare clinical practice guideline (CPG) recommendations and reported physician management of acute paediatric asthma in the 11 largest paediatric emergency departments, all of which have CPGs, in Australia (n = 9) and New Zealand (n = 2). All 11 sites participate in the Paediatric Research in Emergency Departments International Collaborative (PREDICT) research network. METHODS: (a) A review of CPGs for acute childhood asthma from all PREDICT sites. (b) A standardised anonymous survey of senior emergency doctors at PREDICT sites investigating management of acute childhood asthma. RESULTS: CPGs for mild to moderate asthma were similar across sites and based on salbutamol delivery by metered dose inhaler with spacer and oral prednisolone. In severe to critical asthma, differences between sites were common and related to recommendations for: ipratropium use; metered-dose inhaler versus nebulised delivery of salbutamol in severe asthma; use of intravenous aminophylline, intravenous magnesium and dosing of intravenous salbutamol in critical asthma. The questionnaire (78 of 83 doctors responded) also revealed significant differences between doctors in the treatment of moderate to severe asthma. Ipratropium was used for moderate asthma by 42%. For severe to critical asthma, nebulised delivery of salbutamol was preferred by 79% of doctors over metered dose inhalers. For critical asthma, doctors reported using intravenous aminophylline in 45%, intravenous magnesium in 55%, and intravenous salbutamol in 87% of cases. Thirty-nine different dosing regimens for intravenous salbutamol were reported. CONCLUSIONS: CPG recommendations and reported physician practice for mild to moderate paediatric asthma management were broadly similar across PREDICT sites and consistent with national guidelines. Practice was highly variable for severe to critical asthma and probably reflects limitations of available evidence. Areas of controversy, in particular the comparative efficacy of intravenous bronchodilators, would benefit from multi-centre trials. Collaborative development of CPGs should be considered.
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Antiasmáticos/administración & dosificación , Asma/tratamiento farmacológico , Pautas de la Práctica en Medicina/estadística & datos numéricos , Enfermedad Aguda , Albuterol/administración & dosificación , Antiinflamatorios/administración & dosificación , Australia , Niño , Quimioterapia Combinada , Femenino , Adhesión a Directriz/estadística & datos numéricos , Encuestas de Atención de la Salud , Humanos , Masculino , Inhaladores de Dosis Medida , Nueva Zelanda , Guías de Práctica Clínica como Asunto , Prednisolona/administración & dosificación , Índice de Severidad de la EnfermedadAsunto(s)
Disfunción Eréctil/psicología , Matrimonio/psicología , Prostatectomía/psicología , Neoplasias de la Próstata/cirugía , Disfunción Eréctil/rehabilitación , Estudios de Seguimiento , Humanos , Masculino , Grupo de Atención al Paciente , Satisfacción del Paciente , Complicaciones Posoperatorias/psicología , Complicaciones Posoperatorias/rehabilitación , Estudios Prospectivos , Prostatectomía/rehabilitación , Neoplasias de la Próstata/patología , Neoplasias de la Próstata/psicología , Calidad de Vida , SexualidadRESUMEN
Salutogenesis means a paradigmatic change in medicine. While pathogenesis restricts itself to finding out what makes a man ill, salutogenesis tries to find out what keeps him or her healthy. The human being is seen as a biological, psychological, and social creature. There are many studies which show the importance of social relationships and the satisfaction of basic psychosocial needs as protection against psychological or psychosomatic disorders. The psychosocial basic needs for acceptance, intimacy, and security can be best fulfilled by sexual communication with the partner. Therefore a salutogenic approach to sexual medicine focuses mainly on the fulfillment of these needs and not only on the treatment of a sexual dysfunction. Unnecessarily frustrating experiences can thus be avoided, especially when the sexual possibilities of one or both partners are restricted by an illness or its medical treatment. A case report shows how sexual communication and sex therapy can help to cope with a tumor disease.
Asunto(s)
Atención a la Salud/tendencias , Relaciones Interpersonales , Psicología , Sexología/métodos , Sexología/tendencias , Disfunciones Sexuales Fisiológicas/diagnóstico , Disfunciones Sexuales Fisiológicas/terapia , Alemania , Humanos , Disfunciones Sexuales Fisiológicas/psicología , SexualidadRESUMEN
Noninvasive Doppler cardiac output measurements are clinical standards in adults and children. Presently, these standard Doppler methods generally require relatively expensive and large imaging equipment with complex signal-processing techniques. Thus, universal access to these important measurements has been limited. Simple, portable Doppler methods have been validated previously and applied to infants and children without cardiac disease. Nevertheless, these specific, inexpensive techniques have not been validated in children with complex congenital heart disease. Accordingly, we compared a noninvasive, suprasternal, non-image-guided, pulsed Doppler cardiac output with standard invasive Fick cardiac outputs in 20 patients (age range, 1 month to 15 years) with congenital heart disease. Doppler cardiac output was displayed by multiplying the mean velocity with an operator-selected angiographic or echographic estimate of the aortic diameter. The values from linear regression analysis were r = 0.96; Doppler cardiac output = 0.98 x Fick cardiac output - 0.08 L/min (range, 0.55-3.10 L/min). The 95% confidence limits were less than 35% of the mean of Doppler and Fick cardiac outputs across the range of measurements. We conclude that relatively linear and accurate measurements of cardiac output can be made by this simple, inexpensive, portable method in selected infants and children with various forms of congenital heart disease.
Asunto(s)
Gasto Cardíaco , Ecocardiografía Doppler de Pulso/métodos , Cardiopatías Congénitas/diagnóstico por imagen , Adolescente , Cateterismo Cardíaco , Niño , Preescolar , Cardiopatías Congénitas/fisiopatología , Pruebas de Función Cardíaca/métodos , Humanos , Lactante , Recién Nacido , Modelos Lineales , Oxígeno/sangre , Consumo de OxígenoRESUMEN
BACKGROUND: Acute rheumatic fever (ARF) remains the leading cause of acquired heart disease in children worldwide. No therapeutic agent has been shown to alter the clinical outcome of the acute illness. Immunological mechanisms appear to be involved in the pathogenesis of ARF. Intravenous immunoglobulin (IVIG), a proven immunomodulator, may benefit cardiac conditions of an autoimmune nature. We investigated whether IVIG modified the natural history of ARF by reducing the extent and severity of carditis. METHODS AND RESULTS: This prospective, double-blind, randomized, placebo-controlled trial evaluated IVIG in patients with a first episode of rheumatic fever, stratifying patients by the presence and severity of carditis before randomization. Patients were randomly allocated to receive 1 g/kg IVIG on days 1 and 2 and 0.4 g/kg on days 14 and 28, or they received a placebo infusion. Clinical, laboratory, and echocardiographic evaluation was performed at 0, 2, 4, 6, 26, and 52 weeks. Fifty-nine patients were treated, of whom 39 had carditis (including 4 subclinical) and/or migratory polyarthritis (n=39). There was no difference between groups in the rate of normalization of the erythrocyte sedimentation rate or acute-phase proteins at the 6-week follow-up. On echocardiography, 59% in the IVIG group and 69% in the placebo group had carditis at baseline. There was no significant difference in the cardiac outcome, including the proportion of valves involved, or in the severity of valvar regurgitation at 1 year. At 1 year, 41% of the IVIG and 50% of the placebo group had carditis. CONCLUSIONS: IVIG did not alter the natural history of ARF, with no detectable difference in the clinical, laboratory, or echocardiographic parameters of the disease process during the subsequent 12 months.
Asunto(s)
Inmunoglobulinas Intravenosas/uso terapéutico , Fiebre Reumática/terapia , Enfermedad Aguda , Proteínas de Fase Aguda/análisis , Sedimentación Sanguínea , Proteína C-Reactiva/análisis , Niño , Método Doble Ciego , Ecocardiografía , Humanos , Miocarditis/patología , Estudios Prospectivos , Fiebre Reumática/sangre , Fiebre Reumática/patología , Factores de TiempoRESUMEN
OBJECTIVES: The purpose of this study was to characterize left ventricular (LV) mechanics during acute rheumatic fever (ARF) and to define factors influencing remodeling after the acute event. BACKGROUND: Acute rheumatic fever is associated with varying degrees of valvulitis and myocarditis, but the impact of these factors on LV mechanics is poorly defined. METHODS: Echocardiograms and clinical data were reviewed in 55 patients aged 11.2 +/- 2.6 years during ARF. Valve regurgitation was absent or mild in 33 (group I) and moderate or severe in 22 (group II). Forty-two children (75%) underwent a further examination after ARF. RESULTS: Group I patients demonstrated a mildly elevated LV size during ARF and had normal indexes at follow-up. Group II patients demonstrated a markedly elevated LV size (end-diastolic dimension z-score 3.6 +/- 1.8, p < 0.01 compared with the normal population) and decreased shortening fraction (z-score -0.8 +/- 1.4, p < 0.05). The stress-velocity index, a z-score describing the velocity of shortening-afterload relationship, was normal in group II patients with mitral regurgitation (-0.2 +/- 1.2, p = NS) but was depressed in those with aortic regurgitation or both (- 1.4 +/- 1.4, p < 0.01). At follow-up the stress-velocity index remained depressed (-1.2 +/- 1.0, p < 0.01) and had deteriorated in those treated nonsurgically compared with those treated surgically (interval change nonsurgical -0.7 +/- 1.2 vs. surgical 1.3 +/- 1.3, p = 0.005). CONCLUSIONS: The evolution of contractile dysfunction during and after ARF is dependent on the degree and type of valve regurgitation and may be influenced by surgical intervention. These findings suggest that mechanical factors are the most important contributors to myocardial damage during and after ARF.
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Insuficiencia de la Válvula Aórtica/diagnóstico , Insuficiencia de la Válvula Mitral/diagnóstico , Contracción Miocárdica/fisiología , Cardiopatía Reumática/diagnóstico , Disfunción Ventricular Izquierda/diagnóstico , Adolescente , Insuficiencia de la Válvula Aórtica/fisiopatología , Volumen Cardíaco/fisiología , Niño , Femenino , Humanos , Masculino , Insuficiencia de la Válvula Mitral/fisiopatología , Pronóstico , Cardiopatía Reumática/fisiopatología , Disfunción Ventricular Izquierda/fisiopatología , Función Ventricular Izquierda/fisiologíaRESUMEN
OBJECTIVE: To review the evolution of transcatheter patent ductus arteriosus (PDA) occlusion techniques and results. METHODS: A single institution, retrospective review including all patients with intention to close a PDA from 1991 to 1998, with no exclusions. RESULTS: Rashkind occluder (n = 65), sideris double-button (n = 6), Cook detachable coil (n = 28) and Amplatzer ductal occluder (n = 4) were used. Successful implantation occurred in 99 of 103 patients. There was a need for a second transcatheter procedure to close residual ductal shunting in 12% of patients: Rashkind umbrellas (n = 8), double-button (n = 1), coils (n = 3). Eight patients (8%) required surgery, including 4 of 6 patients with the double-button occluder. CONCLUSIONS: The Rashkind occluder and the Sideris double-button device both had an unacceptably high rate of residual shunts requiring a second transcatheter procedure or surgical closure. Detachable coils and the Amplatzer ductal occluder have become the current technology of choice for transcatheter PDA closure with high success rates.
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Cateterismo Cardíaco/métodos , Conducto Arterioso Permeable/terapia , Embolización Terapéutica/métodos , Adolescente , Adulto , Niño , Preescolar , Conducto Arterioso Permeable/cirugía , Embolización Terapéutica/instrumentación , Femenino , Estudios de Seguimiento , Humanos , Lactante , Masculino , Persona de Mediana Edad , Recurrencia , Estudios Retrospectivos , Resultado del TratamientoAsunto(s)
Procedimientos Quirúrgicos del Sistema Digestivo/efectos adversos , Endocarditis Bacteriana/prevención & control , Procedimientos Quirúrgicos Orales/efectos adversos , Procedimientos Quirúrgicos Urogenitales/efectos adversos , Bacteriemia/complicaciones , Bacteriemia/epidemiología , Bacteriemia/prevención & control , Endocarditis Bacteriana/epidemiología , Endocarditis Bacteriana/etiología , Humanos , Nueva Zelanda/epidemiología , Prevalencia , Factores de RiesgoRESUMEN
The prevention of infective endocarditis is extremely important for people with valvular heart disease and other high-risk cardiac conditions. The following is the National Heart Foundation's updated recommendations for the prophylaxis of infective endocarditis. The recommended antibiotic regimens have changed considerably from the previous guidelines. In response to these guidelines, Pharmac has instituted a number of changes to the Schedule to reduce the barriers to prescribing the recommended drugs for this indication. Pharmac expects that the last of these drugs to be listed on the Schedule (cefuroxime axetil) will be in place by 1 October 1999. Prescriptions will need to be endorsed "prophylaxis for endocarditis". Therefore, any prescriber (doctor or dentist) will be able to prescribe the recommended drugs on an endorsed prescription but, until 1 October 1999, some of the drugs may not be fully subsidised. Pharmac will be informing prescribers of the details of these changes in the near future. The Ministry of Health has recently alerted practitioners to the possible risk of heart valve damage following the long-term use of weight-loss drugs fenfluramine (Ponderax) and dexfenfluramine (Adifax). All patients who have taken these drugs for longer than 3 months should have a clinical check and, if any abnormality is detected, should be referred to a cardiologist. If mild or greater aortic or mitral regurgitation is present, antibiotic prophylaxis against endocarditis is recommended.--Boyd A Swinburn, Medical Director, National Heart Foundation.
Asunto(s)
Profilaxis Antibiótica , Atención Odontológica , Endocarditis Bacteriana/prevención & control , Adulto , Fármacos Antiobesidad/efectos adversos , Insuficiencia de la Válvula Aórtica/inducido químicamente , Cefuroxima/análogos & derivados , Cefuroxima/uso terapéutico , Cefalosporinas/uso terapéutico , Niño , Preescolar , Dexfenfluramina/efectos adversos , Prescripciones de Medicamentos , Fenfluramina/efectos adversos , Cardiopatías/complicaciones , Enfermedades de las Válvulas Cardíacas/inducido químicamente , Enfermedades de las Válvulas Cardíacas/complicaciones , Humanos , Insuficiencia de la Válvula Mitral/inducido químicamente , Profármacos/uso terapéutico , Factores de Riesgo , Agonistas de Receptores de Serotonina/efectos adversosRESUMEN
Modification of the double-button (Sideris) patent ductus arteriosus (PDA) occluder has resulted in a single-strut aortic component rather than the conventional cross-strut design. We report the use of this infant PDA occluder for transcatheter closure in three patients with PDA measuring 2 mm, 3.7 mm, and 4 mm. Subclinical aortic perforation with a small aortic aneurysm developed in two patients 1 year after occluder implantation. The third patient had developed a small aortic aneurysm without perforation at 3-month follow-up. All three patients had a residual shunt and underwent successful PDA surgical closure with aortic aneurysmal repair. Single-strut umbrella designs are not recommended for PDA transcatheter closure.
Asunto(s)
Aorta Torácica/lesiones , Rotura de la Aorta/etiología , Conducto Arterioso Permeable/terapia , Implantación de Prótesis/efectos adversos , Aorta Torácica/diagnóstico por imagen , Aneurisma de la Aorta Torácica/diagnóstico por imagen , Aneurisma de la Aorta Torácica/etiología , Rotura de la Aorta/diagnóstico por imagen , Aortografía , Preescolar , Diseño de Equipo , Femenino , Estudios de Seguimiento , Humanos , Masculino , Implantación de Prótesis/instrumentación , Tomografía Computarizada por Rayos XRESUMEN
OBJECTIVES: This study examines the late outcome in patients with simple transposition of the great arteries (TGA) after a Mustard operation. BACKGROUND: Continuing medical follow-up for patients after the Mustard procedure, now extending to three decades, is required. The quality of life of adult survivors has not been well documented. METHODS: Survival and quality of life among 113 hospital survivors of the Mustard operation performed for simple TGA between 1964 and 1982 were assessed by medical review and a lifestyle questionnaire. The incidence of right ventricular failure and echocardiographic right ventricular dysfunction (RVD) were determined. A measure of lifestyle, the ability index, was determined. RESULTS: Actuarial survival was 90%, 80%, and 80% at 10, 20, and 28 years, respectively, with 76% of survivors being New York Heart Association class 1. Sudden death, with an incidence of 7% without identifiable risk factors, was the most common cause of late demise. RVD was identified in 18% of patients who had echocardiography, but there was right ventricular failure in only two patients. Seventy-five percent of current survivors lead a normal life, 20% have some symptoms or lifestyle modification, and 5% are unable to work. CONCLUSIONS: The survival of patients to 28 years with the Mustard repair has been good. Late sudden death is the most worrisome feature. There is a 97% freedom from right ventricular failure to date. The quality of life of late survivors is good, most achieving a normal level of education and employment.
Asunto(s)
Complicaciones Posoperatorias/mortalidad , Transposición de los Grandes Vasos/cirugía , Actividades Cotidianas/clasificación , Adolescente , Adulto , Niño , Preescolar , Evaluación de la Discapacidad , Femenino , Estudios de Seguimiento , Humanos , Lactante , Recién Nacido , Masculino , Complicaciones Posoperatorias/cirugía , Calidad de Vida , Reoperación , Tasa de Supervivencia , Transposición de los Grandes Vasos/mortalidadRESUMEN
AIMS: To study the epidemiological trends of nontuberculous mycobacterial lymphadenitis affecting New Zealand children from 1986-95. METHODS: Cases were identified from the records of the three regional reference laboratories in New Zealand. All children of less than 16 years with a positive culture of nontuberculous mycobacteria from a lymph node tissue sample were included. RESULTS: One hundred and sixty eight cases were identified, 43 in the first 5 years (no data available from Waikato) and 125 in the second 5 years of the study period. One hundred and fifty three (91%) of cases were in the 0-5 year age group and 101 (60%) were female. The head and neck was the most common site of infection accounting for 141 (84%) of all infection. In 161 (96%) of cases the causative organism was Mycobacterium avium intracellulare complex. CONCLUSION: Nontuberculous mycobacterial infections cause a subacute lymphadenitis in preschool children, usually affecting the lymph nodes of the head and neck. The annual number of microbiologically confirmed cases in New Zealand had increased substantially over recent years, most notably since 1992. The reason for the increase is unknown but possible explanations include increased awareness of mycobacterial disease, external factors causing either changes in the distribution or virulence of mycobacteria in the environment and alterations in the human immune response.