RESUMEN
An optical-microcavity-based sensor is an important building block for an optofluidics system, because it allows us to fabricate small devices with high sensitivity. Here we describe the detection of NaCl and pH in water using a silica toroid microcavity. First we demonstrate the detection of NaCl particles, and show that a detection sensitivity of 0.38 mM is possible with a sample volume of 0.03 nl. Then, we report the detection of NaCl ions in liquid and demonstrate a sensitivity of 3.20 mM and also, in principle, the detection of pH with a sensitivity of 0.14 pH. Finally, we integrate a tapered optical fiber, a silica toroid microcavity, and a fluidic channel for future optofluidics applications.
RESUMEN
Peters Plus syndrome is a very rare autosomal recessive condition characterized by ocular defects (typically Peters anomaly) and other systemic major/minor anomalies. Mutations in the B3GALTL gene encoding beta 1,3-glucosyltransferase have been found in virtually all patients with typical Peters Plus syndrome. We report on a female patient with unusually severe manifestations of Peters Plus syndrome, including anterior eye staphyloma, cleft lip and palate, and hypoplastic left heart syndrome (HLHS). Analysis of the B3GALTL gene revealed no mutation in the patient. To our knowledge, HLHS has not previously been reported in Peters Plus syndrome so far, and anterior staphyloma, a most severe defect of the anterior eye chamber, is also apparently rare in the syndrome. Our patient might represent a new syndrome of severe Peters Plus syndrome-like phenotype with anterior eye staphyloma and HLHS.
