RESUMEN
In the complex anion of the title compound, (C(2)H(6)N(5))[Cu(C(7)H(4)NO(4))(C(7)H(3)NO(4))]·3H(2)O, the Cu(II) atom is coordinated by tridentate 6-carb-oxy-pyridine-2-carboxyl-ate and pyridine-2,6-dicarboxyl-ate ligands and is surrounded by four O atoms in the equatorial plane and two N atoms in axial positions in a distorted octa-hedral geometry. In the crystal, the components are linked into a three dimensional network by O-Hâ¯O, N-Hâ¯O, N-Hâ¯N and C-Hâ¯O hydrogen bonds and a π-π inter-action with a centroid-centroid distance of 3.6080â (8)â Å.
RESUMEN
o-Vanillin-(4-methylthiosemicarbazone), o-Vanillin-(4-phenylthiosemicarbazone) and some of their metal complexes of the platinum group have been synthesized, characterized by chemical and spectral methods and studied for their antibacterial, antifungal and amoebicidal activity in vitro. The platinum group metal chelates exibited significant activity against a wide spectrum of microorganisms at different concentrations. The Pt(II) and Ru(III) chelates derived from o-vanillin-(4-phenylthiosemicarbazone) seem to be the most efficient inhibitors. Evaluation of the antimalarial activity of the compounds in mice infected with Plasmodium berghei indicated that cures were attainable at dose levels of 40-160 mg/kg but with toxic death prevalence at higher dose levels.
Asunto(s)
Antiinfecciosos/síntesis química , Compuestos Organoplatinos/síntesis química , Tiosemicarbazonas/síntesis química , Animales , Antibacterianos , Antiinfecciosos/farmacología , Antiinfecciosos/toxicidad , Antifúngicos/síntesis química , Antifúngicos/farmacología , Antimaláricos/síntesis química , Antimaláricos/farmacología , Antiprotozoarios/síntesis química , Antiprotozoarios/farmacología , Bacterias/efectos de los fármacos , Entamoeba histolytica/efectos de los fármacos , Femenino , Hongos/efectos de los fármacos , Dosificación Letal Mediana , Ligandos , Espectroscopía de Resonancia Magnética , Malaria/tratamiento farmacológico , Malaria/parasitología , Masculino , Ratones , Pruebas de Sensibilidad Microbiana , Compuestos Organoplatinos/farmacología , Compuestos Organoplatinos/toxicidad , Espectrofotometría Infrarroja , Espectroscopía Infrarroja por Transformada de Fourier , Tiosemicarbazonas/farmacología , Tiosemicarbazonas/toxicidadRESUMEN
2-Acetylpyridine-(2-methylthiosemicarbazone), 2-acetylpyridine-(4-methylthiosemicarbazone), 2-acetylpyridine-(4-phenylthiosemicarbazone) and some of their metal complexes of the platinum group have been synthesized, characterized by chemical and spectral methods and studied for their antibacterial, antifungal and amoebicidal activity in vitro. They were studied also for their antimalarial activity and for toxicity in vivo. The platinum metal chelates exhibited significant activity against a wide spectrum of microorganisms at different concentrations. The Ru (III) chelates derived from 2-acetylpyridine-(4-methylthiosemicarbazone) seem to be the most efficient inhibitors. Evaluation of the antimalarial activity of the complexes in mice infected with Plasmodium berghei indicated that cures were attainable at dose levels of 20-160 mg/kg.
Asunto(s)
Antiinfecciosos/síntesis química , Metales/química , Tiosemicarbazonas/síntesis química , Animales , Antiinfecciosos/química , Antiinfecciosos/farmacología , Antifúngicos/síntesis química , Antifúngicos/química , Antifúngicos/farmacología , Antimaláricos/síntesis química , Antimaláricos/química , Antimaláricos/farmacología , Antiprotozoarios/síntesis química , Antiprotozoarios/química , Antiprotozoarios/farmacología , Metales/farmacología , Ratones , Pruebas de Sensibilidad Microbiana , Espectrofotometría Infrarroja , Tiosemicarbazonas/química , Tiosemicarbazonas/farmacologíaRESUMEN
The metal (II) complexes of benzyl and benzoin thiosemicarbazones have been synthesized and characterized. They were studied for their antibacterial, antifungal and amoebicidal activity in vitro and for their toxicity in vivo. The ligands and their metal complexes exhibited low antibacterial and amoebicidal activity. The metal chelates of benzoin thiosemicarbazone seem to be the most active compounds.
Asunto(s)
Antiinfecciosos/síntesis química , Metales/farmacología , Tiosemicarbazonas/síntesis química , Animales , Antibacterianos , Antiinfecciosos/farmacología , Bacterias/efectos de los fármacos , Entamoeba histolytica/efectos de los fármacos , Hongos/efectos de los fármacos , Dosificación Letal Mediana , Ratones , Tiosemicarbazonas/farmacologíaRESUMEN
2-Acetylpyridine-(4-methylthiosemicarbazone), 2-acetylpyridine-(2- methylthiosemicarbazone) and their metal (II) complexes have been synthesized and characterized by chemical and spectral methods. They were studied for their antibacterial, antifungal and amoebicidal activity in vitro and for their toxicity in vivo. The ligands and their metal (II) complexes exhibited significant activity against a wide spectrum of microorganisms. The metal (II) complexes derived from 2-acetylpyridine-(4-methylthiosemicarbazone) seem to be the most active compounds.
Asunto(s)
Antiinfecciosos/síntesis química , Compuestos Organometálicos/síntesis química , Tiosemicarbazonas/síntesis química , Amebicidas/síntesis química , Amebicidas/farmacología , Amebicidas/toxicidad , Animales , Antibacterianos , Antiinfecciosos/farmacología , Antiinfecciosos/toxicidad , Antifúngicos/síntesis química , Antifúngicos/farmacología , Antifúngicos/toxicidad , Bacterias/efectos de los fármacos , Entamoeba histolytica/efectos de los fármacos , Hongos/efectos de los fármacos , Ratones , Pruebas de Sensibilidad Microbiana , Compuestos Organometálicos/farmacología , Compuestos Organometálicos/toxicidad , Espectrofotometría Infrarroja , Tiosemicarbazonas/farmacología , Tiosemicarbazonas/toxicidadRESUMEN
2-Acetylpyridine-(4-phenylthiosemicarbazone) and its metal (II) complexes have been synthesized and characterized by chemical and spectral methods. They were studied for their antibacterial and antifungal activities in vitro. The ligand and its metal (II) complexes exibited significant activity against a wide spectrum of bacteria and fungi.