RESUMEN
The levels of anti-Müllerian hormone, follicle-stimulating hormone, and testosterone were studied in rats after removal of the uterine horns, oviducts, or combined surgery. The effects of preventive salpingectomy on ovarian reserve were studied. After preventive salpingectomy, the level of anti-Müllerian hormone was low throughout the experiment, follicle-stimulating hormone increased only by the end of observation (on day 40), and testosterone level decreased only on day 10. Hysterectomy alone caused no changes in the concentrations of the studied hormones on day 10 after surgery. Salpingectomy alone reduced the concentrations of anti-Müllerian hormone and testosterone and did not change the level of follicle-stimulating hormone during this period.
Asunto(s)
Trompas Uterinas/cirugía , Reserva Ovárica/genética , Procedimientos Quirúrgicos Profilácticos , Salpingectomía/métodos , Útero/cirugía , Animales , Hormona Antimülleriana/sangre , Hormona Antimülleriana/genética , Trompas Uterinas/metabolismo , Femenino , Hormona Folículo Estimulante/sangre , Hormona Folículo Estimulante/genética , Expresión Génica , Histerectomía/métodos , Ratas , Ratas Wistar , Testosterona/sangre , Testosterona/genética , Útero/metabolismoRESUMEN
Morphological study of ovarian follicular cysts induced by chorionic gonadotropin (300 U) and insulin (Protafane HM; 2.5 U) in adult rats showed that superovulatory dose of chorionic gonadotropin and moderate hyperinsulinemia induced the development of ovarian cysts on days 3-5 in 100% cases. Dynamic study of ovarian morphology showed that changes were reversible and the cysts regressed within 60 days, which confirmed their functional nature.
Asunto(s)
Gonadotropina Coriónica , Insulina , Quistes Ováricos , Ovario , Animales , Gonadotropina Coriónica/metabolismo , Gonadotropina Coriónica/farmacología , Femenino , Insulina/metabolismo , Insulina/farmacología , Quistes Ováricos/metabolismo , Quistes Ováricos/patología , Ovario/citología , Ovario/efectos de los fármacos , RatasRESUMEN
Using the methods of light and electron microscopy, morpho-functional changes of the ovaries of albino rats after their monopolar coagulation were studied. Electrocoagulation was shown to cause hemodynamic changes in a perifocal area and short-term stimulation of follicular growth, but starting already at postoperational day 3, their atresia was increased, while by day 30 a significant reduction in number of both primordial and growing follicles, as well as of corpora lutea, was found. Ultrastructural changes of oocytes in primary and secondary follicles outside the coagulation zone were demonstrated at early stages and included the reduction of porous plate, cortical and yolk granule numbers, and the increase in numbers of lysosomes and multivesicular bodies. Ascovertin, due to its antioxidant properties and by improving hemorheological parameters, exerts a protective action on ovarian generative apparatus and the state of microcirculation in the organ.
