Sarcoma de Ewing/Pnet primário pré-sacral: relato de caso / Ewing Sarcoma/Pnet pre-sacral: case report

O sarcoma de Ewing é um tipo de tumor ósseo, de comportamento agressivo, que acomete principalmente indivíduos abaixo dos 30 anos e com predomínio no sexo masculino. A família de tumores de Ewing compreende um espectro de neoplasias de células neuroectodérmicas primitivas as quais são células embrionárias que migram da crista neural. Neste relato apresenta-se paciente do sexo masculino, 19 anos, admitido na emergência com quadro de lombalgia, fraqueza de membros inferiores, dificuldade de urinar e fratura de fêmur direito há um ano. Solicitada ressonância magnética da pelve e coluna lombosacra que evidenciaram lesão expansiva pré-sacral e lesões extramedulares e intradurais. Paciente submetido a exame anatomopatológico que evidenciou sarcoma de Ewing/Tumor Neuroectodérmico Primitivo. Realizado tratamento cirúrgico para descompressão medular e posterior radioterapia e quimioterapia...

Ewing’s sarcoma is a type of bone tumor that has aggressive behavior, which mainly affects individuals below 30 years and predominantly in males. The family of tumors includes Ewing a spectrum of neuroectodermal of primitive cells tumors which are embryonic cells migrating from the neural crest. In this report we present a male patient, 19 years, admitted to the emergency room with back pain, weakness of the lower limbs, difficulty urinating and right femur fracture a year ago. Requested magnetic resonance imaging of the pelvis and lumbosacral spine showed a presacral mass lesion and extramedullary and intradurallesions. Patient has been subjected to the pathological examination that showed Ewing’s sarcoma / primitive neuroectodermal tumor. Surgery for spinal decompression and subsequent radiotherapy and chemotherapy have been conducted...

Interleukin-6 and C-reactive protein are overexpressed in the liver of perinatal deaths diagnosed with fetal inflammatory response syndrome.

Anatomopathologic studies have failed to define the fetal inflammatory response syndrome (FIRS) as a cause of fetal death. Here, liver fragments of perinatal autopsies were collected at a university hospital from 1990 to 2009 and classified according to the cause of death, perinatal stress, and gestational age (GA) of the fetus. IL-6, TNF-α, and C-reactive protein (CRP) expression were immunostained, respectively, with primary antibody. Cases with congenital malformation, ascending infection, and perinatal anoxia showed increased IL-6, CRP, and TNF-α, respectively. Prematures presented higher expression of IL-6 whereas term births showed higher expression of CRP. Cases classified as acute stress presented higher expression of IL-6 and TNF-α and cases with chronic stress presented higher expression of CRP. GA correlated negatively with IL-6 and positively with CRP and TNF-α. Body weight correlated negatively with IL-6 and positively with CRP and TNF-α. Despite the diagnosis of FIRS being clinical and based on serum parameters, the findings in the current study allow the inference of FIRS diagnosis in the autopsied infants, based on an in situ liver analysis of these markers.