RESUMEN
â¢Compartment syndrome is a rare complication of prolonged lithotomy position.â¢We report a case of compartment syndrome complicating radical hysterectomy.â¢Prompt diagnosis is crucial to reduce morbidity from compartment syndrome.â¢Awareness of this complication allows surgeons to address modifiable risk factors.
RESUMEN
A 61-year-old woman with no significant past history underwent gastric biopsies demonstrating a strongly c-kit-positive epithelioid malignancy, initially thought to represent gastrointestinal stromal tumor (GIST). Subsequent clinical and immunohistochemical evaluation proved the neoplasm to represent metastatic lobular carcinoma. This case illustrates that although c-kit is highly specific and sensitive for GIST, its expression may occur in a variety of other neoplasms, some of which morphologically resemble GIST and may present in the gastrointestinal tract as metastases. Therefore, a review of other c-kit-positive lesions is also highlighted.
Asunto(s)
Neoplasias de la Mama/diagnóstico , Carcinoma Lobular/diagnóstico , Carcinoma Lobular/secundario , Tumores del Estroma Gastrointestinal/diagnóstico , Proteínas Proto-Oncogénicas c-kit/metabolismo , Neoplasias Gástricas/diagnóstico , Neoplasias Gástricas/secundario , Neoplasias de la Mama/metabolismo , Neoplasias de la Mama/patología , Carcinoma Lobular/metabolismo , Diagnóstico Diferencial , Femenino , Tumores del Estroma Gastrointestinal/metabolismo , Humanos , Persona de Mediana Edad , Metástasis de la Neoplasia , Neoplasias Gástricas/metabolismoRESUMEN
Lynch syndrome is a genetic cancer predisposition syndrome caused by an inherited defect in 1 of 4 DNA mismatch repair genes (mutL homolog 1, mutS homolog 2, mutS homolog 6, and postmeiotic segregation 2). Despite the theoretically increased risk in all tissues, Lynch syndrome exhibits tissue specificity, with a particular tendency among affected individuals to develop colorectal and endometrial cancer at a young age. A number of other malignancies, including those derived from the ovary, stomach, small bowel, and urothelium, have also been linked to this syndrome. A growing body of evidence exists to support an association between mismatch repair mutations and a growing spectrum of hereditary nonpolyposis colon cancer-associated neoplasms. In this article, a previously undocumented mismatch repair-related malignancy in a patient with Lynch syndrome is reported.
