Characterization of the inflammatory response in the uteri of cows infected naturally by Neospora caninum.

Bovine neosporosis manifests during gestation, when the fetus may be vulnerable to pathogens. Experimental studies of Neospora caninum-infected cattle have been performed, but little is known about the in-utero inflammatory response. The aim of this study was to characterize the inflammatory response in the uteri of pregnant and non-pregnant cows infected naturally with N. caninum. Four groups of seven animals were studied. Two groups consisted of N. caninum-seropositive pregnant and non-pregnant cows and the other two groups contained N. caninum-seronegative pregnant and non-pregnant cows. Uterine and placental samples were subjected to immunohistochemistry using antibodies specific for N. caninum, CD4, CD8, CD14 and CD21. The non-pregnant seropositive and seronegative groups did not show a difference (P >0.05) in the types of cells present. There were more lymphocytes in the uteri of the seropositive pregnant animals (P <0.05) than in the seronegative pregnant animals, but this was not considered to be consistent with an inflammatory process. N. caninum cysts were detected in eight seropositive cows; five were non-pregnant and three were pregnant. CD4(+) T cells were distributed in the endometrium and myometrium of the non-pregnant cows and were sparse in the placentomes of pregnant cows. CD8(+) T cells were distributed in a similar manner, but were present in smaller number. There were no cells expressing CD14 or CD21. The results of the study suggest that there is no consistent uterine inflammatory response against N. caninum in naturally infected animals.

A specific T-cell receptor genotype preference in the immune response to a synthetic Plasmodium falciparum malaria vaccine.

In recent studies with 63 and 122 volunteers vaccinated with the SPf 66 synthetic malaria vaccine, specific antibody patterns were classified as high or low responders. Using the Polymerase Chain Reaction (PCR), a specific and selective preference was shown for the V beta arrangement of the T-cell receptor in the high responder group involving the V beta-8 gene. The low responder group showed the rearrangement of a different set of genes, and a particular association with V beta-10.

[Prevalence of bronchial asthma in a student population in Guadalajara City, Jal. México]. / Prevalencia del asma bronquial en población escolar en la ciudad de Guadalajara, Jal. México.

In an intent to know the bronchial Asthma prevalence in our school children we performed a prospective descriptive survey of 1064 children. The diagnosis was confirmed by clinical history, physical examination and skin test. We found an accumulative prevalence of 12.8% with predominance in males. The 93.4% had confirmed diagnosis, the 30% had need for hospitalization in the last school year. We also analyze the age of onset, family history of allergy and school absenteeism. Bronchial asthma is a common ill at school age, affecting school attendance and family habits and finances.

Estudios clinicos y complementarios a propostio de un caso de alcaptonuria familiar. / Clinical and complementary studies in a case of familial alkaptonuria

Se presenta un caso de alcaptonuria familiar, detectado en dos hermanos examinados en la catedra. En base a ello, se ponen de manifiesto las lesiones clinicas visibles y estudios de laboratorio efectuados para comprobar la aumentada excrecion de acido homogentisico en orina, caracteristica de esta enfermedad. Asimismo, se investiga la inactividad enzimatica de la homogentisico-oxidasa, hecho desencadenante de los trastornos, a traves de biopsia hepatica.Comparativamente, se relacionan los hallazgos en los demas familiares directos de los pacientes que presentaron el cuadro; este es considerado autosomica recesiva.Finalmente, se describen los resultados y conclusiones

Estudios clinicos y complementarios a propostio de un caso de alcaptonuria familiar. / Clinical and complementary studies in a case of familial alkaptonuria

Se presenta un caso de alcaptonuria familiar, detectado en dos hermanos examinados en la catedra. En base a ello, se ponen de manifiesto las lesiones clinicas visibles y estudios de laboratorio efectuados para comprobar la aumentada excrecion de acido homogentisico en orina, caracteristica de esta enfermedad. Asimismo, se investiga la inactividad enzimatica de la homogentisico-oxidasa, hecho desencadenante de los trastornos, a traves de biopsia hepatica.Comparativamente, se relacionan los hallazgos en los demas familiares directos de los pacientes que presentaron el cuadro; este es considerado autosomica recesiva.Finalmente, se describen los resultados y conclusiones

Sobre conectivos nodulares. Granuloma anular profundo (G.A.P.). / Nodular conectivosis (deeper annular granuloma

Se presenta un caso de G.A.P. demostrado clinica e histopatologicamente. Comparativamente, se mencionan otros cuadros hipodermicos, que podrian presentar un diagnostico diferencial. No son muchos los casos relatados de esta enfermedad, encuadrada dentro de las conectivosis nodulares cuya distincion principal es la degeneracion mucoidotica focalizada de las fibras colagenas. Su pronostico es benigno y la evolucion favorable, entre otras diferencias clinicas

Aplasia cutis congenita: estudio de cuatro casos. / Aplasia cutis congenita: study of 4 cases

Se presentan cuatro casos de aplasia cutis congenita, donde se destacan las caracteristicas clinicas e histopatologicas tipicas de la enfermedad y fundamentalmente el diagnostico diferencial con procesos traumaticos durante el mecanismo del parto. Al examen clinico, los cuatro ninos no revelaron anomalias sistemicas

Sobre conectivos nodulares. Granuloma anular profundo (G.A.P.). / Nodular conectivosis (deeper annular granuloma

Se presenta un caso de G.A.P. demostrado clinica e histopatologicamente. Comparativamente, se mencionan otros cuadros hipodermicos, que podrian presentar un diagnostico diferencial. No son muchos los casos relatados de esta enfermedad, encuadrada dentro de las conectivosis nodulares cuya distincion principal es la degeneracion mucoidotica focalizada de las fibras colagenas. Su pronostico es benigno y la evolucion favorable, entre otras diferencias clinicas

Aplasia cutis congenita: estudio de cuatro casos. / Aplasia cutis congenita: study of 4 cases

Se presentan cuatro casos de aplasia cutis congenita, donde se destacan las caracteristicas clinicas e histopatologicas tipicas de la enfermedad y fundamentalmente el diagnostico diferencial con procesos traumaticos durante el mecanismo del parto. Al examen clinico, los cuatro ninos no revelaron anomalias sistemicas

[Effect of L-tetramisol associated with rifampicin in patients with lepromatous leprosy. L-tetramisol in patients with lepromatous leprosy]. / Acción del L-tetramisol asociado a la rifampicina en pacientes con lepra lepromatosa. L-tetramisol en pacientes con lepra lepromatosa.

In this work are presented results obtained in the treament of thirty patients suffering of lepromatous leprosy. In a group of fifteen patients L-tetramisol was administrated in association to antimocrobian drugs. The control group received only the last medication. Immunological modifications were not observed in any case. However, in six patients treated with L-tetramisol associated to rifampicin during three months it was possible to observe a notable improvement of the clinical state. In the patients that received L-tetramisol associated to other drugs or in those that received only antimicrobian drugs the clinical improvement was very low or null.