Evolución del tratamiento del cáncer de cérvix en Guipúzcoa, 1998-2002 / No disponible

Propósito: A partir de 1999, la evidencia disponible recomienda un cambio en el enfoque de lostratamientos. Nuestro propósito es describir las características de los tumores de cérvix tratados enGuipúzcoa durante 1998 y analizar las diferencias en los tratamientos entre 1998 y 2002 en los tumoresinvasivos.Material y métodos: La identificación de los casos se realizó a partir de los Registros de TumoresHospitalarios (RTH) y en su defecto de los Archivos del Servicio de Anatomía Patológica yAltas Hospitalarias. La recogida de información fue a partir de los RTH y RCPG (Registro de CáncerPoblacional de Guipúzcoa) y mediante revisión de historias clínicas para las variables no incluídas endichos registros.Resultados: En 1998 en Guipúzcoa se trataron 91 casos. El número de tumores invasivos diagnosticadosen residentes en Guipúzcoa fue de 25 en 1998 y 20 en 2002. En 1998 la clasificación porestadios de la totalidad de tumores tratados en Guipúzcoa fue: estadio 0, 41.8%; estadio I, 17.7%; estadioII, 17,6%; estadio III, 18,7%; y estadio IV, 4.4. La proporción de tumores tratados con radioterapiay quimioterapia con o sin cirugía en estadios II, III y IV aumenta significativamente del año 1998al 2002: 21.4% versus 72.7%; p=0.01.Conclusiones: Entre 1998 y 2002 el tratamiento del cáncer de cérvix invasivo cambia significativamenteadecuándose a la evidencia científica disponible

Purpose: Beginning in 1999, the available evidence recommended a change of focus in thetreatment of cervical cancer. We describe cervical tumours treated in Guipúzcoa during 1998 andanalyse the differences in the treatment of invasive tumours between 1998 and 2002.Material and methods: Cases were identified from the Hospital Tumour Registries (HTR)and, where not available, from the Archives of the Anatomic Pathology Service and HospitalDischarges. Information was collected from the HTR and the Guipúzcoa Population Cancer Registryand by review of clinical records for variables not included in these registries.Results: Ninety-one cases of cervical carcinoma diagnosed and/or treated in Guipúzcoa in 1998were included. The number of invasive tumours diagnosed in residents of Guipúzcoa was 25 in 1998and 20 in 2002. In 1998 the classification by stage of all such tumours treated in Guipúzcoa was: stage0, 41.8%; stage I, 17.7%; stage II, 17.6%; stage III, 18.7%; and stage IV, 4.4%. The proportion oftumours treated with radiation therapy and chemotherapy with or without surgery in stages II, III andIV increased significantly from 1998 to 2002: 21.4% versus 72.7%; p=0.01.Conclusion: Between 1998 and 2002 the treatment of invasive cervical cancer in Guipúzcoa changed significantly, in line with the available scientific evidence (AU)

[Non-Hodgkin's lymphoma in childhood. Review of 33 cases]. / Linfoma no Hodgkin infantil. Revisión de 33 casos.

A retrospective study was performed of 33 cases of non Hodgkin's lymphoma in children diagnosed in our hospital. The mean age was 10 years and there were 24 males and 9 females. The distribution, according to Rappaport's diagnostic classification, was: 11 undifferentiated lymphomas, 9 lymphoblastic lymphomas, 6 diffuse histiocytic lymphomas, and 7 cases of other types. Of the 33 patients, 23 had bulky disease (over 5 cm. in diameter). The mean serum LDH and uric acid values were, respectively, 537 (68-2021) and 6.0 (2.7-19). According to Murphy's staging system, the distribution of the cases was as follows: I (1), II (4), III (12), IV (16). Since this study spreads for a long period, several protocols have been used in the treatment of the group, but most patients received the LSA2-L2 regimen. Complete remission (CR) was achieved in 26 cases (78%), this being 100% of the lymphoblastic lymphomas. After a mean follow-up of 45 months, the actuarial survival is 48.1%, and the disease-free survival of patients attaining CR is 60.4%. The prognostic factors analysed, such as histologic type, stage, and serum LDH showed no statistical significance, probably due to the low number of cases studied.