[Study on coagulation fibrinolytic systems in predialysis patients with chronic renal failure--comparison between patients with chronic glomerulonephritis and patients with diabetic nephropathy].

To clarify the abnormalities of coagulation and fibrinolytic systems on predialysis patients with chronic renal failure, we measured indices of coagulation and fibrinolytic systems in 33 predialysis patients whose creatinine (Cr) levels were over 3.0 mg/dl. We termed twenty-four patients with chronic glomerulonephritis the "CGN group". We also termed nine patients wit diabetes mellitus the "DM group". We measured thrombin.antithrombin III complex (TAT), alpha 2-plasmin inhibitor plasmin complex (PIC), D-dimer, protein C, protein S, thrombomodulin (TM), vitronectin, tissue plasminogen activator.plasminogen activator inhibitor-1 complex (tPAI-C) in theses two groups. Furthermore, we measured the same indices after 6 months in the CGN group. As a result, the plasma levels of both TAT, PIC, TM/Cr ration in the DM group were significantly higher that those in the CGN group, changes in both protein S activities and plasma levels of tPAI-C were reduced significantly after 6 months. In conclusion, the abnormalities of coagulation and fibrinolytic systems in predialysis diabetic patients were stronger than those in predialysis patients with CGN. Furthermore, these abnormalities were worsened after 6 months in predialysis patients with chronic renal failure.

[Clinical study on sulbactam/cefoperazone in urinary tract infections in elderly patients].

A clinical study on sulbactam/cefoperazone was performed and the following results were obtained. Sulbactam/cefoperazone was administered intravenously to 30 elderly patients with urinary tract infections. Those patients were treated with 1g of sulbactam/cefoperazone 2 times daily. 1. Clinical efficacies in 24 cases of complicated urinary tract infections were excellent in 8, moderate in 11 and poor in 5, with an overall efficacy rate of 79.2%. As to bacteriological responses, 20 of 25 strains identified in the complicated urinary tract infections were eradicated, with an eradication rate of 80%. 2. Clinical efficacies in two cases of acute uncomplicated pyelonephritis were excellent in 1 and moderate in 1, with an overall efficacy rate of 100%. Bacteriologically, two of the strains in the acute uncomplicated pyelonephritis was eradicated, with an eradication rate of 100%. 3. Safety evaluation was made in all 30 patients received sulbactam/cefoperazone. No adverse reactions were observed in any cases. As to laboratory test results, slight elevation of GPT was noted in 1 patient. In conclusion, sulbactam/cefoperazone is considered as a clinically useful antibiotics in the treatment of urinary tract infections with elderly patients.

[Treatment of seventy-eight patients with testicular tumors].

Seventy-eight patients with testicular tumors were treated in our clinic between April, 1972 and October, 1990. The average age of patients with seminoma (37.5 yrs) was higher than that (24.5 yrs) of those with non-seminomatous germ cell tumor (NSGCT). Histopathologically, 34 patients had seminoma and 36 patients had NSGCT. The remaining 8 patients had non-germinal cell tumors. The 5-year survival rate was 76.7%, 90.3% and 75.8% for all patients, seminoma group and NSGCT group, respectively. As for seminoma group, the 5-year survival rate was 100%, 50.0% and 33.3% for Stage I, Stage IIb and Stage III, respectively. The survival rate of Stage IIb and Stage III in seminoma group were lower than Stage I statistically. In NSGCT group, the 5-year survival rate was 100% for Stage I and 26.7% for Stage III, between the two groups there was significant difference. The higher serum LDH and HCG levels, the lower the survival rate in NSGCT. Serum AFP, beta-HCG levels and ESR were unrelated to the survival rate. The survival rate for the patients treated by the chemotherapy including CDDP was compared to those treated by the other therapy in germ cell tumor (greater than or equal to Stage IIb). The survival rate of CDDP group was higher than the others (p less than 0.01).

Studies on interfacial electrochemical phenomena in pigment-vehicle systems.

Sedimentation potentials under a centrifugal field are studied with the disperse system titanium dioxide, alkyd resin and xylene. The relationships between the sedimentation potential and the rotation speed, the distance apart of the electrodes in the cell and the total weight of particles in the disperse system are examined. From the theoretical evaluation of the initial sedimentation potential, the zeta potential of the pigment in the disperse system is calculated. The calculated value was almost coincident with that obtained by the electrophoretic method. As the sedimentation potential is proportional to the total weight of pigment in the space between the electrodes in the cell, the particle-size distribution of pigment can be obtained from the sedimentation potential-time curve. The particle-size distribution in the above-mentioned disperse system was examined with respect to the effect of rotation speed and the pigment content. The modal diameter for the particle-size distribution obtained by this method had almost the same value as that obtained by the electron microscope method. By use of this method for particle-size analysis, the particle-size distribution for particles of diameter < 1 mum can be obtained in a short time (ca, 10-30 min) and the zeta potential of the particles in the disperse system can be calculated.