Factors Associated with Significant Weight Loss in Hospitalised Patients with COVID-19: A Retrospective Cohort Study in a Large Teaching Hospital.

SARS-CoV-2 infection (COVID-19) is associated with malnutrition risk in hospitalised individuals. COVID-19 and malnutrition studies in large European cohorts are limited, and post-discharge dietary characteristics are understudied. This study aimed to assess the rates of and risk factors for ≥10% weight loss in inpatients with COVID-19, and the need for post-discharge dietetic support and the General Practitioner (GP) prescription of oral nutritional supplements, during the first COVID-19 wave in a large teaching hospital in the UK. Hospitalised adult patients admitted between March and June 2020 with a confirmed COVID-19 diagnosis were included in this retrospective cohort study. Demographic, anthropometric, clinical, biochemical, and nutritional parameters associated with ≥10% weight loss and post-discharge characteristics were described. Logistic regression models were used to identify risk factors for ≥10% weight loss and post-discharge requirements for ongoing dietetic input and oral nutritional supplement prescription. From the total 288 patients analysed (40% females, 72 years median age), 19% lost ≥ 10% of their admission weight. The length of hospital stay was a significant risk factor for ≥10% weight loss in multivariable analysis (OR 1.22; 95% CI 1.08-1.38; p = 0.001). In addition, ≥10% weight loss was positively associated with higher admission weight and malnutrition screening scores, dysphagia, ICU admission, and artificial nutrition needs. The need for more than one dietetic input after discharge was associated with older age and ≥10% weight loss during admission. A large proportion of patients admitted to the hospital with COVID-19 experienced significant weight loss during admission. Longer hospital stay is a risk factor for ≥10% weight loss, independent of disease severity, reinforcing the importance of repeated malnutrition screening and timely referral to dietetics.

Comparing Computerised Dietary Analysis with a Ready Reckoner in a Real World Setting: Is Technology an Improvement?

Ready reckoners are used in the clinical setting as a tool for the estimation of nutrient intake. With increasing opportunities for nutrition research, ready reckoners may provide for a more rapid analysis of nutritional intake than computerised methods, often seen as the gold standard for nutritional analysis. This research aimed to determine the level of agreement between ready reckoner and computerised dietary analysis through a secondary analysis of clinical trial data. Participant food intakes were estimated by trained observers using the one-quarter method. Daily energy and protein intake were estimated by the healthcare network ready reckoner and computerised dietary analysis. Agreement between methods was tested using t-tests, correlations and Bland-Altman plots. A correlation between analysis methods was observed (r = 0.9086 energy, r = 0.8700 protein). Wide limits of agreement were observed for both energy and protein intake. Compared with the computerised method, ready reckoner analysis underestimated energy intake by 600 kJ and protein intake by 5 g. Mean energy and protein intake calculated by each method was significantly different (p < 0.0001 energy; p < 0.0001 protein). No time differences between analysis methods were observed. In the clinical setting, practitioners should be aware of the variability of a ready reckoner compared to computerised dietary analysis. Further investigation into the acceptability of ready reckoners as a reliable method of nutrient intake determination, particularly for analysis of nutrition research, is required.

Should we implement mealtime assistance in the hospital setting? A systematic literature review with meta-analyses.

AIMS AND OBJECTIVES: This review aimed to determine the effect of mealtime assistance provided to hospitalised patients (≥65 years) by nurses, trained staff or volunteers on nutritional and anthropometric outcomes. BACKGROUND: Malnutrition is a critical issue in hospitals with a reported prevalence of 20-50%. Nutritional supplementation has been associated with increased weight gain, improved function and decreased mortality; however, other system approaches including mealtime assistance may also contribute to improving nutritional intake. DESIGN: A systematic literature review. METHODS: Six electronic databases (CINAHL Plus, Cochrane Library, ProQuest Nursing and Allied Health Source, Scopus, PsycINFO and MEDLINE) were searched from their inception to August 2014. Inclusion criteria were hospitalised patients ≥65 years, provided mealtime assistance by nurses, volunteers or trained staff. Studies were examined for quality and risk of bias. Outcome data were combined narratively and by meta-analyses. RESULTS: From 5458 publications, five studies met the inclusion criteria. Studies were rated neutral and positive according to the Academy of Nutrition and Dietetics Quality Checklist. Adherence to study protocols was not always reported. Meta-analyses demonstrated significantly greater daily energy and protein intake where mealtime assistance was provided. Anthropometric outcomes generally did not differ significantly with mealtime assistance. Observation and sampling bias were noted in several studies. CONCLUSIONS: There is evidence that mealtime assistance increases daily energy and protein intake in hospitalised patients (≥65 years). More robust research is needed to elucidate whether this strategy may be an effective means of addressing the high prevalence of malnutrition in hospitals. RELEVANCE TO CLINICAL PRACTICE: The evidence identified suggests that mealtime assistance provided to hospitalised older patients (≥65 years) leads to a statistically significant increase in energy and protein intake. For many patients, this increase in both energy and protein intake will be clinically significant, reducing the gap between requirements and actual intake.