RESUMEN
OBJECTIVES: This study analysed the frequency of anterior uveitis (AU) and its correlations in a large cohort of patients with spondyloarthritis (SpA). METHODS: A common protocol of investigation was prospectively applied to 2012 SpA patients in 85 centres from 10 Ibero-American countries. Clinical and demographic variables and disease indexes were investigated. Categorical variables were compared by χ2 and Fisher's exact test, and continuous variables were compared by ANOVA or Kruskal-Wallis test. A value of p<0.05 was considered significant. RESULTS: AU was referred by 372 SpA patients (18.5%). AU was statistically associated with inflammatory low back pain (p<0.001), radiographic sacroiliitis (p<0.001), enthesopathies (p=0.004), urethritis/acute diarrhoea (p<0.001), balanitis (p=0.002), hip involvement (p=0.002), HLA-B27 (p=0.003), and higher C-reactive protein (p=0.001), whilst it was negatively associated with the number of painful (p=0.03) and swollen (p=0.005) peripheral joints, psoriatic arthritis (p<0.001), psoriasis (p<0.001), nail involvement (p<0.001), and dactilitis (p=0.062; trend). No association with gender, race, and indices (disease activity, functionality and quality of life) was observed. Logistic regression showed that ankylosing spondylitis (p=0.001) and HLA-B27 (p=0.083; trend) was significantly associated with AU, while extra-articular manifestations (predominantly psoriasis) were negatively associated (p=0.016). CONCLUSIONS: Anterior uveitis is a frequent extra-articular manifestation in SpA patients, positively associated with axial involvement and HLA-B27 and negatively associated with peripheral involvement and psoriatic arthritis.
Asunto(s)
Antígeno HLA-B27/metabolismo , Psoriasis/epidemiología , Espondiloartritis/epidemiología , Uveítis Anterior/epidemiología , Adolescente , Adulto , América Central/epidemiología , Femenino , Humanos , Articulaciones/patología , Modelos Logísticos , Masculino , Persona de Mediana Edad , Prevalencia , Estudios Prospectivos , Psoriasis/metabolismo , Psoriasis/patología , Sistema de Registros/estadística & datos numéricos , América del Sur/epidemiología , Espondiloartritis/metabolismo , Espondiloartritis/patología , Uveítis Anterior/metabolismo , Uveítis Anterior/patología , Adulto JovenRESUMEN
En Uruguay se desconoce la prevalencia de las espondiloartritis (SpA). Desde 2002 funciona el Grupo Uruguayo de Espondiloartropatías (GUES) dedicado al estudio de los pacientes portadores de estas enfermedades. Objetivos: Presentar las características de las SpA incluidas en RESPONDIA Uruguay. Metodología: Se analizan los datos de 53 pacientes uruguayos con SpA incluidos en la página electrónica del Registro de Espondiloartritis de la Sociedad Española de Reumatología (REGISPONSER) entre enero de 2006 y diciembre de 2007. Resultados: Los pacientes fueron predominantemente varones (66%), de raza blanca (86,8%), de clase social media y baja (88,1%), alfabetos y con una edad media de 41,2 años. La edad de inicio de los síntomas indicativos de SpA fue de 31,6 años, con manifestaciones clínicas axiales en 69,8%. Se constató un retraso diagnóstico de 9,8 años, y más frecuencia de espondiloartritis anquilosante (53%), espondiloartritis indiferenciada (19%) y artropatía psoriásica (17%). El 98% recibió antiinflamatorios no esteroideos y ninguno tratamiento biológico. Conclusiones: A pesar de un mayor retraso diagnóstico y edad de inicio, los resultados coincidieron con los de la bibliografía (AU)
Objectives: To evaluate the characteristics of patients with SpA (ESSG criteria) included in RESPONDIA Uruguay. Methodology: A cross-sectional study was performed with the records of 53 patients belonging to GUES who were assisted in a referral rheumatologic center in Montevideo, between January 2006 and December 2007. Data were stored in the Spanish SpA Registry website (REGISPONSER). Results: Patients were mainly men (66%), whites (86.8%), and of middle and low social levels (88.1%), literate persons, with an average age of 41.2 years. Age of onset of global SpA was 31.6 years on average, with axial clinical features in 69.8%. Global diagnosis delay average was 9.8 years. Most frequent SpA subgroups were: ankylosing spondylitis (53%), undifferentiated SpA (19%) and psoriatic arthritis (17%). Nearly 98% patients received non-steroidal anti-inflammatory drugs, but none underwent biological therapy. Conclusions: Except higher diagnosis delay and age of onset, results were similar to international data (AU)