Biomechanical mechanisms of anterior cruciate ligament injury in the jerk dip phase of clean and jerk: A case study of an injury event captured on-site.

Background: Weightlifting exposes athletes to significant loads, potentially placing the knee joint in an abnormal mechanical environment and leading to anterior cruciate ligament (ACL) injuries. Once an ACL injury occurs, it can affect athletes' competitive ability to varying degrees and even prematurely end their career. Understanding the biomechanical mechanisms of ACL injuries in weightlifters helps in comprehensively understanding the stress patterns and degrees on ACL during human movement, and identifying potential injury-causing factors, thereby enabling the implementation of appropriate preventive measures to reduce the occurrence of injuries. This study aimed to explore the biomechanical mechanisms of ACL injuries during the jerk dip phase of clean and jerk in weightlifters, providing a theoretical basis for the prevention of ACL injuries in weightlifting sports. Methods: This study utilized the German SIMI Motion 10.2 movement analysis system and the AnyBody simulation system to analyze the kinematic and dynamic parameters of a 109 kg + class weightlifter (height: 191 cm, age: 22 years, weight: 148 kg, athletic level: elite) performing a 205 kg clean and jerk (non-injured) and a 210 kg clean and jerk (ACL injury occurred). The differences in kinematic and dynamic indicators of lower limb joints under injured and non-injured jerk dip conditions were investigated. Results: Knee joint torque during non-injured clean and jerk was consistently positive (i.e., external rotation) but turned from positive to negative (i.e., from external rotation to internal rotation) during injured clean and jerk and reached a maximum internal rotation torque of 21.34 Nm at the moment of injury. At every moment, the muscle activation and simulated muscle force of the quadriceps and gastrocnemius during the injured clean and jerk were higher than those during the non-injured clean and jerk. By contrast, the muscle activation and simulated muscle force of the semitendinosus, semimembranosus, biceps femoris, and soleus during non-injured clean and jerk were higher than those during injured clean and jerk. The knee joint internal rotation angle during injured clean and jerk first increased and then declined, reaching a peak at 46.93° at the moment of injury, whereas it gradually increased during non-injured clean and jerk. The proximal tibia on the left side during the injured clean and jerk moved forward faster by 0.76 m/s compared with that during the non-injured clean and jerk. Conclusions: The small muscle activation and simulated muscle force of the hamstring and soleus could not resist timely and effectively the large muscle activation and simulated muscle force of the quadriceps (especially the medial quad) and gastrocnemius. As such, the force applied to the ACL could exceed its ultimate load-bearing capacity. Kinematic indicators in the athlete's injured lift demonstrated certain disparities from those in their non-injured lift. Knee internal rotation and tibial anterior translation during the jerk dip phase of weightlifting might be the kinematic characteristics of ACL injuries.

Does swing leg braking matter in long jump take-off? A 3-D kinematic analysis based on elite athletes.

The objective of this study was to explore the braking technical characteristics of the swing leg of elite male athletes in long jump take-off and its dependencies on the extension velocity of the support leg and the balance. Two cameras were used to capture 8 elite male long jump athletes (25.88 ± 3.00 years) under competitive conditions at a National Indoor Athletic Championships Final, a 3-D kinematic analysis method was conducted to analyze the take-off technique of the athletes. The results showed that the rapid braking of the swing leg increased the extension velocity of the support leg. Compared to the swing leg that started braking at the moment of maximum knee flexion of the support leg (SPKnee maximum flexion moment), athletes' performance was greater when swing leg started braking at the moment of maximum ankle flexion of the support leg (SPAnkle maximum flexion moment). Furthermore, the swing leg exhibited an inward movement during its forward swing, and the inward angle was significantly correlated with the balance maintenance (r = - 0.50,P = 0.004). In conclusion, a relatively delayed rapid braking and moderate inward movement of the swing leg during the take-off phase are conducive to achieving a better take-off effect in long jump.

Neuroprotective effects of voluntary exercise and Yisaipu after traumatic brain injury in mice.

The mechanisms underlying exercise-induced neuroprotective effects after traumatic brain injury (TBI) remained elusive, and there is a lack of effective treatments for TBI. In this study, we investigated the effects of an integrative approach of exercise and Yisaipu (TNFR-IgG fusion protein, TNF inhibitor) in a mouse TBI model. Male C57BL/6J mice were randomly assigned to a sedentary group or a group that followed a voluntary exercise regimen. The effects of 6-week prophylactic preconditioning exercise (PE) alone or in combination with post-TBI Yisaipu treatment on moderate TBI associated deficits were examined. The results showed that combined treatments of PE and post-TBI Yisaipu were superior to single treatments on reducing sensorimotor and gait dysfunctions in mice. These functional improvements were accompanied by reduced systemic inflammation largely via decreased serum TNF-α, boosted autophagic flux, and mitigated lesion volume after TBI. Given these neuroprotective effects, composite approaches such as a combination of exercise and TNF inhibitor may be a promising strategy for facilitating functional recovery from TBI and are worth further investigation.

A Biomechanical Study on Failed Snatch Based on the Human and Bar Combination Barycenter.

Objective: The purpose of this research was to use a new method the human and bar combination barycenter to exposit the differences between successful and failed characteristics of snatch attempts in competition. Try to establish an effective biomechanical method that can uncover the main factors for the failed snatch. The obtained results will provide valuable information for weightlifters to improve the success rate in snatch by altering their technical issues accordingly. Methods: A 3-D video analysis method was used to compare the characteristics of the heaviest successful and failed attempts of ten elite weightlifters in the men's 73 kg category. The video was captured under competitive conditions at the 2019 World Weightlifting Championships, the 2019 Asian Weightlifting Championships, and the 2020 China Olympic Trial. The video data were digitized using the SIMI°Motion7.50 3-D system (Germany). Results: Significant difference (P > 0.05) was not found between the successful and failed attempts in the parameters, such as the maximal vertical rising velocity, the maximal vertical height, and the vertical displacement of the barbell. The maximal descending acceleration of the human body, the time duration, the angles of the hip, and knee joints were no significant difference. However, significant differences were found in the variation of the human and bar combination barycenter on the X-axis in the inertial ascent stage and the squat support stage (t = 2.862, P < 0.05; t = 3.376, P < 0.05). Conclusions: A probable cause of the failed snatch is that the displacement of human and bar combination barycenter on the X-axis is not enough to reach the position for supporting barbell during the inertial ascent stage and the squat support stage. The reason is that the strength of reclining of torso at the end of the force phase is insufficient. Insufficient knee flexion in the knee flexion phase (M2), which leads to a lower maximum vertical velocity of barbell, may be an indirect factor leading to the failed snatch. The cumulative variation of human and bar combination barycenter on the X-axis can effectively determine the technical characteristics between the success and failure in snatch.

Modified device for fluid percussion injury in rodents.

Fluid percussion (FP) injury model is a popular animal model of traumatic brain injury (TBI), but still there are some issues need to be addressed. To increase the validity and reliability of this technique, we adapted the FP device using electromagnetic protractor, stainless-steel cylinder, changing pressure transducer position, and foam pads to adjust the parameters of FP pulse. Besides, the adjusted FP device is more automatic. The FP pulse is promptly measured and displayed in a graphic user interface software. The modified device resulted in reliable FP pulse. The accuracy of the pendulum leveling was improved with using the electromagnetic protractor with slots. We then collected behavioral, cognition, electrophysiological, and immunohistochemical data to verify the percussion effects in TBI mice. Lateral fluid percussion injury (FPI) or sham treatment was administered at the right frontal motorsensory region of male C57BL/6J mice. TBI mice showed evident motor, cognitive, and functional impairments, characterized by evaluation of neurological, righting, geotaxis and cliff aversion reflexes, limb asymmetrical use, rotarod running, and Morris water maze testing. The neurobehavioral damages were scaled with histopathological findings. Further, the overall firing rates and theta powers in hippocampal CA1 were significantly reduced in TBI mice compared to sham mice at Days 2 and 3 after electrode implanting. The adapted device induced effects on behavior and biology in mice that agree with existing models. These findings confirmed the validity of adjustments, and the modified device may boost the interest in TBI studies.

Brain abscess associated with multidrug-resistant Capnocytophaga ochracea infection.

Brain abscesses are occasionally associated with a dental source of infection. An unusual case of frontal lobe abscess in a nonimmunocompromised child infected with multidrug-resistant Capnocytophaga ochracea is described and confirms the pathogenic potential of this organism to cause human disease in the central nervous system.

Antimicrobial drug resistance in pathogens causing nosocomial infections at a university hospital in Taiwan, 1981-1999.

To determine the distribution and antimicrobial drug resistance in bacterial pathogens causing nosocomial infections, surveillance data on nosocomial infections documented from 1981 to 1999 at National Taiwan University Hospital were analyzed. During this period, 35,580 bacterial pathogens causing nosocomial infections were identified. Candida species increased considerably, ranking first by 1999 in the incidence of pathogens causing all nosocomial infections, followed by Staphylococcus aureus and Pseudomonas aeruginosa. Candida species also increased in importance as bloodstream infection isolates, from 1.0% in 1981-1986 to 16.2% in 1999. The most frequent isolates from urinary tract infections were Candida species (23.6%), followed by Escherichia coli (18.6%) and P. aeruginosa (11.0%). P. aeruginosa remained the most frequent isolates for respiratory tract and surgical site infections in the past 13 years. A remarkable increase in incidence was found in methicillin-resistant S. aureus (from 4.3% in 1981-1986 to 58.9% in 1993-1998), cefotaxime-resistant E. coli (from 0% in 1981-1986 to 6.1% in 1993-1998), and cefotaxime-resistant Klebsiella pneumoniae (from 4.0% in 1981-1986 to 25.8% in 1993-1998). Etiologic shifts in nosocomial infections and an upsurge of antimicrobial resistance among these pathogens, particularly those isolated from intensive care units, are impressive and alarming.