[New data on the pharmacokinetics of aminostigmine]. / Novye dannye o farmakokinetike aminostigmina.

The results of studying the pharmacokinetics of aminostigmine, a new reversible cholinesterase inhibitor produced in Russia, are discussed. Tissue radioactivity after intragastric administration of a toxic dose of aminostigmine was quite quickly absorbed from the intestinal lumen. The half-life period of aminostigmine exceeded considerably that of earlier studied carbamates and correlated with the clinical manifestations of the drug effects. This confirms that the use of aminostigmine in the treatment of neurologic and somatic diseases is preferable.

[Erythrocyte structural changes as a possible reason for the low effectiveness of specific therapy for carbophos poisoning]. / Strukturnye izmeneniia éritrotsitov kak vozmozhnaia prichina nizkoi éffektivnosti spetsificheskoi terapii otravlenii karbofosom.

By method of scanning electron microscopy erythrocyte structure was studied in rats in carbophos poisoning. Following up to 76% acetylcholinesterase inhibition with distinct symptoms of intoxication nearly 30% of erythrocytes were deformed and tended to aggregate. Observation of blood circulation in vessels of pia mater revealed formation of erythrocyte conglomerations in vascular bed. Erythrocytes get stuck in small vessels, disturbing blood microcirculation. Supposedly, obstruction of the smallest vessels with conglomerations is one of the reasons of exotoxic shock development and low efficiency of treatment of carbophos poisoning by means of specific antidotal cholinolytic drugs and cholinesterase reactivators.