Informatics progress of the Global Burden of Animal Diseases programme towards data for One Health.

The Global Burden of Animal Diseases (GBADs) programme will provide data-driven evidence that policy-makers can use to evaluate options, inform decisions, and measure the success of animal health and welfare interventions. The GBADs' Informatics team is developing a transparent process for identifying, analysing, visualising and sharing data to calculate livestock disease burdens and drive models and dashboards. These data can be combined with data on other global burdens (human health, crop loss, foodborne diseases) to provide a comprehensive range of information on One Health, required to address such issues as antimicrobial resistance and climate change. The programme began by gathering open data from international organisations (which are undergoing their own digital transformations). Efforts to achieve an accurate estimate of livestock numbers revealed problems in finding, accessing and reconciling data from different sources over time. Ontologies and graph databases are being developed to bridge data silos and improve the findability and interoperability of data. Dashboards, data stories, a documentation website and a Data Governance Handbook explain GBADs data, now available through an application programming interface. Sharing data quality assessments builds trust in such data, encouraging their application to livestock and One Health issues. Animal welfare data present a particular challenge, as much of this information is held privately and discussions continue regarding which data are the most relevant. Accurate livestock numbers are an essential input for calculating biomass, which subsequently feeds into calculations of antimicrobial use and climate change. The GBADs data are also essential to at least eight of the United Nations Sustainable Development Goals.

Le programme " Impact mondial des maladies animales " (GBADs) a pour but de réunir des éléments probants axés sur des données, qui soient exploitables par les décideurs politiques pour évaluer les solutions envisagées, fonder leurs décisions et mesurer le succès des interventions dans les domaines de la santé et du bien-être des animaux. L'équipe informatique du GBADs a conçu un processus transparent pour l'identification, l'analyse, la visualisation et le partage des données, grâce auquel il sera possible d'estimer l'impact des maladies du bétail et de réaliser des modèles et des tableaux de bord sur le sujet. Les données ainsi réunies peuvent être combinées avec celles couvrant d'autres problématiques ayant un impact mondial (santé humaine, pertes de récoltes, maladies d'origine alimentaire) afin de fournir l'éventail complet d'informations Une seule santé requis pour faire face à des enjeux tels que la résistance aux agents antimicrobiens ou le changement climatique. La première phase du programme a consisté à recueillir des données ouvertes auprès de diverses organisations internationales (qui procèdent également à leur propre transformation numérique). Les efforts déployés pour parvenir à une estimation précise des effectifs des cheptels ont mis en lumière les difficultés à trouver les données détenues par différentes sources, à y accéder et à les recouper au fil du temps. Des ontologies et des bases de données graphiques sont en cours d'élaboration pour résoudre le problème des silos de données et pour améliorer la facilité de recherche et l'interopérabilité des données. Les données du GBADs sont désormais expliquées sous forme de tableaux de bord, de récits construits à partir des données, ainsi que dans un site web documentaire et un Manuel de gouvernance des données, tous disponibles via une interface de programmation d'applications. Le partage des évaluations de la qualité des données renforce la confiance dans ces dernières et encourage à les appliquer pour traiter les problématiques affectant l'élevage ou relevant de l'approche Une seule santé. Les données relatives au bien-être animal présentent une difficulté particulière : elles sont, pour l'essentiel, détenues à titre privé et la question de savoir quelles sont les données les plus pertinentes est toujours en discussion. Les effectifs des cheptels doivent avoir été déterminés de manière précise afin de calculer la biomasse animale, élément qui entre par la suite dans le calcul des quantités d'agents antimicrobiens utilisés et des indicateurs du changement climatique. Les données du programme GBADs sont également essentielles au regard d'au moins huit des objectifs de développement durable des Nations Unies.

El programa sobre el Impacto Global de las Enfermedades Animales (GBADs) proporcionará información contrastada y basada en el uso de datos de la que luego puedan servirse los planificadores de políticas para valorar distintas opciones, decidir con conocimiento de causa y medir la eficacia de una u otra intervención en materia de sanidad y bienestar animales. El equipo informático encargado del GBADs está preparando un proceso transparente destinado a seleccionar, analizar, visualizar y poner en común datos que ayuden a calcular la carga de enfermedades del ganado y a guiar la elaboración de modelos y paneles de control. Estos datos pueden ser combinados con datos referidos a otros grandes problemas planetarios (salud humana, pérdida de cultivos, enfermedades de transmisión alimentaria) para obtener el repertorio completo de información en clave de Una sola salud que se necesita para abordar problemáticas como la resistencia a los antimicrobianos o el cambio climático. El programa empezó por reunir datos abiertos procedentes de organizaciones internacionales (inmersas, por otra parte, en su propio proceso de transformación digital). La labor emprendida para estimar con exactitud las cifras de ejemplares del mundo pecuario reveló ciertos problemas a la hora de encontrar, obtener y conciliar datos de distintas fuentes a lo largo del tiempo. Ahora se están elaborando ontologías y bases de datos gráficos para crear conexiones entre los "silos de datos" y lograr que los datos sean a la vez más compatibles entre sí y más fáciles de localizar. Paneles de control, interpretaciones narrativas de los datos ("data stories"), un sitio web de documentación y un manual de gestión de datos ayudan a explicar y aprehender los datos del GBADs, accesibles ahora por medio de una interfaz de programación de aplicaciones. El hecho de poner en común las evaluaciones de la calidad de los datos genera mayor confianza en esta información, promoviendo con ello su aplicación en temas de ganadería y de Una sola salud. Los datos de bienestar animal plantean una particular dificultad, pues gran parte de esta información está en manos privadas y todavía no está claro cuáles son los datos de mayor interés. Disponer de cifras exactas sobre el número de cabezas de ganado es fundamental para efectuar los cálculos de biomasa que después se utilizan para hacer otros cómputos referidos al uso de antimicrobianos y al cambio climático. Los datos del GBADs son asimismo esenciales para al menos ocho de los Objetivos de Desarrollo Sostenible de las Naciones Unidas.

Evidence of exposure to SARS-CoV-2 in cats and dogs from households in Italy.

SARS-CoV-2 emerged from animals and is now easily transmitted between people. Sporadic detection of natural cases in animals alongside successful experimental infections of pets, such as cats, ferrets and dogs, raises questions about the susceptibility of animals under natural conditions of pet ownership. Here, we report a large-scale study to assess SARS-CoV-2 infection in 919 companion animals living in northern Italy, sampled at a time of frequent human infection. No animals tested PCR positive. However, 3.3% of dogs and 5.8% of cats had measurable SARS-CoV-2 neutralizing antibody titers, with dogs from COVID-19 positive households being significantly more likely to test positive than those from COVID-19 negative households. Understanding risk factors associated with this and their potential to infect other species requires urgent investigation.

Evidence of exposure to SARS-CoV-2 in cats and dogs from households in Italy.

SARS-CoV-2 originated in animals and is now easily transmitted between people. Sporadic detection of natural cases in animals alongside successful experimental infections of pets, such as cats, ferrets and dogs, raises questions about the susceptibility of animals under natural conditions of pet ownership. Here we report a large-scale study to assess SARS-CoV-2 infection in 817 companion animals living in northern Italy, sampled at a time of frequent human infection. No animals tested PCR positive. However, 3.4% of dogs and 3.9% of cats had measurable SARS-CoV-2 neutralizing antibody titers, with dogs from COVID-19 positive households being significantly more likely to test positive than those from COVID-19 negative households. Understanding risk factors associated with this and their potential to infect other species requires urgent investigation. ONE SENTENCE SUMMARY: SARS-CoV-2 antibodies in pets from Italy.

Demographic factors as predictors of coping strategies among police officers.

This study examined the effects of demographic factors on coping responses among police officers. A sample of 233 police officers completed the Ways of Coping Questionnaire (Folkman & Lazarus, 1988). The regression analysis showed that the higher the reported educational attainment, the more police officers reported coping which was emotion-focused and seeking social support. The rank of the officer was directly related to reported emotion-focused coping. These results are discussed relative to research on the relations of demographic factors and coping responses among police officers.

Geometric evaluation of mandibular distraction.

In planning mandibular distraction, the deficiency of the vertical ramus and body is measured. The position of the pin placement is evaluated by the following formula: [formula: see text] This is more accurately presented by the new formula. [formula: see text] In one patient the original formula evaluated the pin placement angle to be 9.94, compared with 9.92, in the more accurate but more complex new formula. When the gonial angle is obtuse, the difference is small. When the gonial angle is more acute, as in a normal gonial angle for a 2-year-old child--134 degrees--the difference is still only 0.1 degree. The original formula is simpler to use and is accurate enough for clinical use in mandibular distraction. The distraction distance is not the sum of the vertical ramal deficiency plus the body deficiency but is given by the following formula: [formula: see text] It would be accurate enough to plan the total distraction distance to be less than the sum of the two distances. The more acute the gonial angle is, the less the distraction distance will need to be.

Planning mandibular distraction: preliminary report.

Normal lengths of the vertical ramus, body, and angle of the mandible at different ages are presented. Before mandibular distraction is embarked on, the extent of the deficiency of the mandible is assessed. The length of the vertical ramus and body are measured on cephalometric radiographs or three-dimensional computed tomography (3D CT) scans. Deficiency of the length of the mandible is calculated. The position of the pin placement angle (from the horizontal ramus) is calculated by means of the following formula: 180 degrees minus mandibular angle times vertical ramus deficiency divided by total deficiency. Placing the pins correctly will result in correction of the vertical ramus and body deficiency of the mandible and the excessively obtuse angle of the mandible will become more acute.

Peripheral trigeminal nerve surgery for patients with atypical facial pain.

Atypical facial pain (AFP) is characterized by a constant, poorly defined anatomically aching pain, lacking the paroxysmal quality, trigger point activation, and well-defined anatomical distribution of trigeminal neuralgia. This study examines a set of AFP patients with respect to their responses to external decompression (4 patients) and neurectomy (11 patients). Criteria for trigeminal nerve exploration were: failure of non-operative treatments, the ability to control pain temporarily with local anesthetic nerve blocks, and pain generally located within the anatomical distribution of the affected nerve. Decision as whether to perform an external decompression or neurectomy was based on gross anatomical findings during exploration. A retrospective interview was conducted to evaluate the effects of the chosen procedure in regard to subjective level of pain, freedom from restrictions placed on activities of daily living, and past medical history, including history of the facial pain. The neurectomy procedure (p = 0.022), medical history of autoimmune disease (p = 0.004), and preoperative pain distribution on the left side (p = 0.042), were all found to have a positive effect on outcome. History of psychiatric treatment (p = 0.055) and preoperative affected activities of daily living (p = 0.026) significantly adversely affected the outcome.

Management of a severe zygomatico-orbital fracture with dislocation of the globe into the antrum.

A patient with severe orbital facial trauma with complete dislocation of the globe into the maxillary antrum is presented. Reconstruction of the defect with autogenous bone restored globe position and maintained the visual and ocular-rotary function of the eye.

Idiopathic trigeminal neuralgia complicated by lingual nerve dysesthesia.

The treatment of facial pain disorders has become a multifaceted discipline that involves numerous scientific fields. Diagnostic and treatment modalities may be beneficial to the patient but at times may also complicate the problem and compromise the outcome. We present an interesting case of left trigeminal neuralgia complicated by unassociated lingual nerve dysesthesia.

Lateral canthotomy transconjunctival approach to the orbit.

Multiple surgical approaches to the orbits with the use of the eyelids have been used. The orbital rim incision fell into disfavor because of esthetic considerations. A subciliary approach supplemented by the lateral brow incision is currently the most popular method of approach to the orbital rim. It provides adequate access to the orbit, but it is not without inherent complications, such as unfavorable scarring, ectropion, and entropion. This article describes an alternate approach to the orbit by means of a transconjunctival incision with lateral canthotomy.

Technical innovation: transfacial approach for infraorbital nerve exploration and orbital-maxillary surgery.

A transfacial approach for infraorbital nerve exploration and maxillary surgery has been developed, allowing for good visual access as far posteriorly as the foramen rotundum and anterior maxillary region. This allows for infraorbital osteotomies, peripheral nerve grafting, neurolysis procedures, or combined maxillofacial-neurosurgical procedures with gasserian ganglion exploration and/or grafting. The procedure affords maximum surgical accessibility with good postoperative healing and minimal concerns about potential oral contamination.

The buccinator myomucosal island pedicle flap: anatomic study and case report.

The buccinator myomucosal island pedicle flap is a useful means of introducing relatively large amounts of vascularized mucosa into the oral cavity. Using cadaver dissections and clinical cases, the anatomy and clinical relevance of this tissue are defined. Emphasis is placed on the technical caveats and pitfalls of the procedure.