Chromoblastomycosis treated by Mohs micrographic surgery.

Mohs micrographic surgery has been used to treat a variety of skin cancers with excellent results. We present a case where the application of this technique was used effectively to treat a lesion of localized cutaneous chromoblastomycosis. One year following the surgery no recurrence has occurred.

Pigmented follicular cysts.

Pigmented follicular cysts are newly described cutaneous cysts with characteristic histology. They are usually single pigmented lesions occurring in men between 20 and 63 years of age that often are mistaken for nevi. The eighth case of this newly described cyst is presented; a brief review of epithelial cysts and how they differ from pigmented follicular cysts also is reported.

Chlorpromazine-induced lupuslike disease. Case report and review of the literature.

A lupuslike disease with cutaneous manifestations secondary to the use of chlorpromazine (Thorazine) is presented. Skin biopsy specimens demonstrated classic findings consistent with lupus erythematosus and abundant mucin deposition in the cutaneous lesions--a finding not previously reported to occur in drug-induced lupuslike disease. Laboratory and serologic examinations included a positive antinuclear antibody titer, presence of single-stranded deoxyribonucleic acid (DNA), absence of double-stranded DNA, presence of antihistone antibodies, normal complement level, increased IgM level, and prolongation of partial thromboplastin time. These data confirmed our clinical and histologic diagnosis. Cessation of the medication (chlorpromazine) led to resolution of the skin abnormalities. Electron microscopy revealed electron-dense drug metabolites in vascular endothelial cells, as well as tubuloreticular inclusion bodies. This is only the second reported case of chlorpromazine-induced lupuslike disease with cutaneous manifestations.

Lupus vulgaris responding to double antituberculous therapy.

A patient with a 3 by 4 cm ulcerated lesion on the nose and upper lip in whom previous antibiotics and antifungal treatments for a "mixed infection" were of no avail is presented. Her history revealed that she has had pulmonary and pharyngeal tuberculosis and subsequently scrofuloderma of cervical lymph nodes. She eventually responded well to isoniazid, rifampin, and pyridoxine therapy.

Yellow nail syndrome.

Yellow nail syndrome was first described in 1964 by Samman and White. The full syndrome consists of the triad yellow nails, lymphedema, and pleural effusions with associated respiratory tract involvement. However, yellow nails alone or with any combination of the triad is termed yellow nail syndrome. We are describing a patient with yellow nails and pulmonary disease, whose nails cleared after resolution of his pulmonary condition. Although various therapeutic approaches have been used, the treatment of pulmonary disease was important in our patient.